Results 171 to 180 of about 9,659 (276)

The role of galectins in modulating the tumor microenvironment and driving metastasis in skin cancers. [PDF]

Biol Res
Dabagh M, Ciceu A, Balta C, Trotta MC, Ferraro B, D'Amico G, Hermenean A, Voiculescu VM.   +7 more
europepmc   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

A glycosaminoglycan microarray identifies galectin-4 binding to sulfated glycosaminoglycans. [PDF]

Biochem Biophys Rep
Sano K, Nagatomo M, Shigematsu K, Yamasaki K, Anh DXT, Shibuya A, Otsuka Y, Minamisawa T, Tateno H.   +8 more
europepmc   +1 more source

Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley   +1 more source

Insights into Reproductive Immunology and Placental Pathology, 2nd Edition. [PDF]

Int J Mol Sci
Szukiewicz D.
europepmc   +1 more source

Moringa oleifera Lam. Seed Lectin (WSMoL) Attenuates Parkinsonian Symptoms in Mice via Anti‐Inflammatory, Antioxidant, and Neurotransmitter‐Modulating Effects

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
WSMoL attenuates motor impairment, neuroinflammation, oxidative stress, and monoamine depletion in a rotenone‐induced model of Parkinson's disease. The involvement of D1 receptor‐mediated signaling is demonstrated, providing new insights into the mechanisms underlying its neuroprotective effects and supporting WSMoL as a promising candidate for further
Leydianne Leite de Siqueira Patriota, Emanuel Davi Lima de Matos Leão, Maria Nívea Bezerra da Silva, Amanda de Oliveira Marinho, Bárbara Raíssa Ferreira de Lima, Jainaldo Alves da Costa, Luciclaudio Cassimiro de Amorim, Valéria Bianca de Souza Santos, Patrícia Maria Guedes Paiva, Michelly Cristiny Pereira, Daniella Carla Napoleão, Jorge Vinícius Fernandes Lima Cavalcanti, Leucio Duarte Vieira, Michelle Melgarejo da Rosa, Thiago Henrique Napoleão   +14 more
wiley   +1 more source

Sponge Galectins: Structure, Evolution, and Function. [PDF]

ACS Omega
Sousa ARO, Ferreira da Ponte JAD, Sampaio AH, Nagano CS, Carneiro RF.   +4 more
europepmc   +1 more source

Coordinated inflammatory macrophage and vascular smooth muscle cell remodeling signatures in human atherosclerosis: An integrative single‐cell and bulk transcriptomic analysis

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Integrative single‐cell and bulk transcriptomic analyses identified a highly inflammatory macrophage state and a vascular smooth muscle cell (VSMC) remodeling continuum in human atherosclerotic plaques. Candidate ligand‐receptor and ligand‐associated target gene expression patterns linked inflammatory macrophage activation with osteogenic/modulated ...
Xinyu Dong, Xuesong Hu, Qi Liu, Yuhao Dong, Yan Xuan, Muning Wang, Siyao Chang, Tianyi Lu, Zhiyang Han   +8 more
wiley   +1 more source

Galectin-3-A Multifunctional Molecule and a Key Player in Health and Disease. [PDF]

Molecules
Lupu Surlea A, Negreanu-Pirjol T, Olariu L, Negreanu-Pirjol BS, Jurja S, Lepadatu AC, Basa M, Rosoiu N.   +7 more
europepmc   +1 more source