Results 141 to 150 of about 13,626 (296)

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, EarlyView.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source

Early‐Onset Oral Squamous Cell Carcinoma: Emerging Biological Insights, Risk Factors and Clinical Implications

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Early‐onset oral squamous cell carcinoma (EO‐OSCC), commonly defined as occurring in individuals under 50 years of age, is increasingly recognized as a potentially distinct clinical subset with differences in exposure patterns and tumor biology compared with conventional oral squamous cell carcinoma (OSCC).
Gennaro Musella, Cristina D'Antonio, Federica Canfora, Michele D. Mignogna, Valentino Vellone, Vito Carlo Alberto Caponio, Amerigo Giudice, Alessandro Villa, Daniela Adamo   +8 more
wiley   +1 more source

Influence of Obstructive Sleep Apnea on Maternal and Perinatal Outcomes in Patients With Gestational Diabetes Mellitus

Journal of Sleep Research, EarlyView.
ABSTRACT The prevalence of obstructive sleep apnea (OSA) increases during pregnancy and is associated with gestational diabetes mellitus (GDM), although its clinical impact on birth outcomes remains unclear. We aimed to assess the effect of several OSA criteria and intermittent hypoxia in the third trimester on perinatal outcomes in women with GDM.
María Cerdà Moncadas, Oleksandr Serednytskyy, Ainhoa Álvarez Ruiz De Larrinaga, Laura Cànaves‐Gómez, Andrés Sánchez Barón, Mercedes Codina Marcet, Mónica De La Peña Bravo, Amanda Iglesias Coma, Daniel Morell‐Garcia, José Antonio Peña Zarza, María Paloma Giménez Carrero, María Concepción Piñas Cebrian, Susana García Fernández, Francisco García‐Río, Alberto Alonso‐Fernández   +14 more
wiley   +1 more source

Acidic pH Restricts Non‐Tuberculous Mycobacteria Replication

Molecular Microbiology, EarlyView.
Different nontuberculous mycobacteria (NTM) species display unique replication profiles in acidic pH in vitro which correlates to their replication within human macrophages. Inhibition of the acidic environments within the macrophage enhances bacterial viability emphasising the role of acidic pH during NTM infections.
Parise K. Lockwood, Luiz Pedro Sorio de Carvalho, Rachel P. J. Lai, Maximiliano G. Gutierrez   +3 more
wiley   +1 more source

Exosome‐mediated miR‐4660 delivery inhibits OPN promoted hepatoma cells aggression through targeting LGALS3BP

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
miR‐4660 was found to be downregulated in exosomes derived from SMMC‐OPN cells, a stable HCC cell line that overexpresses OPN. LGALS3BP has been identified as a direct target of miR‐4660, with its expression levels elevated in both SMMC‐OPN cells and their secreted exosomes.
Cuihua Liu, Riwen An, Ting Lin, Lei Qu, Xiaopeng Zheng, Jingkun Lu, Mei Hong, Pengwei Zhao, Fangxin Zhao, Xuan Zhang   +9 more
wiley   +1 more source

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source

A Dynamic Change of Microglial States Occurs During the Transition From Photoreceptor Degeneration to Regeneration in Zebrafish pde6c Mutants

Glia, Volume 74, Issue 6, June 2026.
Zebrafish pde6c mutants undergo photoreceptor degeneration from 5 dpf, but rods regenerate from 4 wpf. scRNA‐seq of retinal microglia reveals dynamic change of states between 5 dpf and 4 wpf. Two states emerge specifically during regeneration. ABSTRACT Microglia, brain‐resident immune cells, maintain brain homeostasis.
Darshini Ravishankar, Yuki Takeuchi, Ichiro Masai   +2 more
wiley   +1 more source

Inhibition of PLA2G15 Alleviates Palmitic Acid‐Induced Lysosomal Membrane Permeabilization in Human Nucleus Pulposus Cells During Intervertebral Disc Degeneration

JOR SPINE, Volume 9, Issue 2, June 2026.
LMP is responsible for lysosomal dysfunction in IDD. The lipid composition changes in the lysosomal membrane, mediated by PLA2G15, are the cause of LMP. The C/EBPα significantly promotes PLA2G15 expression under PA overload stress. Inhibition of PLA2G15 alleviates PA‐induced LMP by inhibiting the hydrolysis of lysosomal membrane phospholipids. ABSTRACT
Liqun Duan, Jiang Jiang, Shuangshuang Tu, Chuanfu Li, Yijun Dong, Yongjin Li, Wenzhi Zhang, Xi Chen   +7 more
wiley   +1 more source

Engagement of a Neighboring Lys Residue by a Salicylaldehyde‐Modified Glycomimetic Ligand Enables Potent and Selective Binding to DC‐SIGN Over L‐SIGN

ChemistryEurope, Volume 4, Issue 5, May 2026.
Mannose derivatives connected to the aminophilic salicylaldehyde tag show high binding affinity for C‐type lectin DC‐SIGN, favored by an imine bond with a protein's Lys residue in the ligand binding site. This reversible‐covalent binding interaction enables ligand selectivity for DC‐SIGN over the closely related L‐SIGN.
Sara Pollastri, Clara Delaunay, Giulia Antonini, Carine Froment, Michel Thépaut, Davide Pasquali, Sarah Mazzotta, Laura Belvisi, Julien Marcoux, Franck Fieschi, Alberto Dal Corso, Anna Bernardi   +11 more
wiley   +1 more source

Unveiling CLC as a Central Regulator of Allergic Rhinitis via the CLC‐CCL26/POSTN Axis: An Integrated Bioinformatics and Experimental Study

Flavour and Fragrance Journal, Volume 41, Issue 3, Page 696-710, May 2026.
We unveil that CLC orchestrates the dual role of eosinophil recruitment via CCL26 and tissue remodelling via POSTN in allergic rhinitis, identifying it as a potential therapeutic target. ABSTRACT Allergic rhinitis (AR) is a chronic airway inflammation driven by a type 2 immune response, yet the molecular mechanisms underlying its persistence and tissue
Fanyu Yuan, Yuhan Dong, Zishuo Guo, Xiaodong Zhao, Jian Liu, Fangyuan Zhu, Shengjie Ge, Chengcheng Liu, Shuai Xu, Ming Xia   +9 more
wiley   +1 more source