Results 121 to 130 of about 9,659 (276)

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Galectins in Regulation of Inflammation and Immunity

, 2014
[[sponsorship]]生物醫學科學研究所[[note]]已出版;有審查制度 ...
Liu, FT;Hsu, DK;Yang, RY;Chen, HT;Saegusa, J
core  

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Structural and Biophysical Characterization of C-Glycosylic 1,2-Thiodisaccharides Reveals Determinants of Selective Binding to Galectin-7 and Galectin-8N. [PDF]

ChemMedChem
The molecular basis of galectin recognition by C‐glycosylic 1,2‐thiodisaccharides is revealed. While Gly‐1 provides a conserved affinity driving interaction, Gly‐2 governs isoform selectivity through contacts with variable CRD regions. Unique galectin‐8N residues are identified as attractive handles for the development of next‐generation selective ...
Tsagkarakou AS, Kantsadi AL, Theodoridou VI, Veliotis N, Lázár L, József J, Juhász L, Kontopidis G, Leffler H, Nilsson UJ, Somsák L, Leonidas DD.   +11 more
europepmc   +2 more sources

Electrical Modalities in the Rehabilitation of Peripheral Nerve Injuries: State of the Literature and Current Clinical Applications

Muscle &Nerve, EarlyView.
ABSTRACT Peripheral nerve injuries (PNIs) are a common cause of long‐term motor and sensory disability despite advances in microsurgical repair. Functional recovery following PNI depends not only on axonal regeneration, but also on preservation of distal nerve pathways, maintenance of neuromuscular junction integrity, prevention of irreversible muscle ...
Sarah M. Smith, Kirsten M. Schlosser, Ranee Munaim, Stephanie H. Vu, JulieAnn H. Uh, Yusha K. Liu   +5 more
wiley   +1 more source

From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics

Precision Medical Sciences, EarlyView.
Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

The intricate relationship between cytokines and galectins in immune modulation

The human immune system is a complex defense mechanism that protects the body against external and internal threats. Disruption of an effective immune response can lead to detrimental effects, such as autoimmune diseases or cancer.
Koenen, Rory R.; id_orcid, Thijssen, Victor L. J. L., Gennesse, Shannah M.   +2 more
core   +1 more source

Host‐induced silencing of the Minc09294 effector gene impairs Meloidogyne incognita and M. Enterolobii infection

Pest Management Science, EarlyView.
Host‐induced gene silencing of the effector candidate Minc09294 significantly impairs Meloidogyne incognita parasitism, markedly reducing gall formation, reproduction, and the development of specialized giant cells, with partial cross‐species effects on M.
João Pedro Abreu‐Sousa, Thuanne Pires Ribeiro, Daniele Heloisa Pinheiro, Valdeir Junio Vaz Moreira, Luanna Pinheiro Alburquerque Freitas Bezerra, Júlia Moura Rosário Santana, Lays Antunes Teixeira, Maria Eugenia Lisei‐de‐Sa, Deyse Alexandra Rosero Alpala, Manoely Abreu Reis, Isabela Tristan Lourenço‐Tessutti, Leonardo Lima Pepino Macedo, Carolina Vianna Morgante, Maria Cristina Mattar Silva, Marcos Fernando Basso, Janice de Almeida‐Engler, Maria Fatima Grossi‐de‐Sa   +16 more
wiley   +1 more source

The Role of Galectins in Asthma Pathophysiology: A Comprehensive Review

Current Issues in Molecular Biology
Galectins are a group of β-galactoside-binding proteins with several roles in immune response, cellular adhesion, and inflammation development. Current evidence suggest that these proteins could play a crucial role in many respiratory diseases such as ...
Andrea Portacci, Ilaria Iorillo, Leonardo Maselli, Monica Amendolara, Vitaliano Nicola Quaranta, Silvano Dragonieri, Giovanna Elisiana Carpagnano   +6 more
doaj   +1 more source

Role of Galectins in Tumors and in Clinical Immunotherapy

, 2018
Galectins are glycan-binding proteins that contain one or two carbohydrate domains and mediate multiple biological functions. By analyzing clinical tumor samples, the abnormal expression of galectins is known to be linked to the development, progression ...
Heng-Yi Chen, Chih-Chi Kuo, Feng-Cheng Chou, Huey-Kang Sytwu   +3 more
core   +1 more source