Results 11 to 20 of about 3,048,170 (258)

Arsenic causing gallbladder cancer disease in Bihar

Scientific Reports, 2023
In recent times Gallbladder cancer (GBC) incidences increased many folds in India and are being reported from arsenic hotspots identified in Bihar. The study aims to establish association between arsenic exposure and gallbladder carcinogenesis.
Arun Kumar, Mohammad Ali, Vivek Raj, Arti Kumari, Mahesh Rachamalla, Som Niyogi, Dhruv Kumar, Ashok Sharma, Amit Saxena, Ghanish Panjawani, Preeti Jain, Ajay Vidyarthi, Navin Kumar, Mukesh Kumar, Pintoo Kumar Niraj, Md. Samiur Rahman, Akhouri Bishwapriya, Ranjit Kumar, Maiko Sakamoto, Santosh Kumar, Manisha Singh, Ashok Kumar Ghosh   +21 more
doaj   +3 more sources

New progress and clinical research translation of immune checkpoint inhibitors in systemic therapy of gallbladder cancer [PDF]

Frontiers in Immunology
Gallbladder cancer (GBC) is a highly malignant tumor of the biliary tract system.Although it is less common than other malignant tumors of the digestive system, its incidence and mortality rates have been on a continuous rise.
Fuhong Li, Yuxiao Wang, Zhiren Xu, Meng Zhu, Kun Su, Xiawei Yang, Tao Wu   +6 more
doaj   +2 more sources

Association of TREM1 expression with mTOR and DRP1 in gallbladder cancer: a study of 105 cases [PDF]

World Journal of Surgical Oncology
Background Gallbladder cancer is highly aggressive and characterized by poor prognosis and limited treatment options. TREM1 (Triggering Receptor Expressed on Myeloid cells 1) may be involved in cancer inflammation and progression, but its relevance to ...
Ziyu Liu, Shumei Wei, Chongyu Wang, Xi Chen, Mengqiu Yin, Tianyu Chen, Jinhui Zhu   +6 more
doaj   +2 more sources

Targeting GALNT7 Disrupts the TAZ O-GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression. [PDF]

Adv Sci (Weinh)
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Qiu P, Zhang M, Feng Y, Deng Y, Zhao K, Li X, Lu Y, Tian L, Yang T, Yao W, Wang J, Deng Z.   +11 more
europepmc   +2 more sources

Clinical study on comprehensive treatment of gallbladder cancer [PDF]

Waike lilun yu shijian, 2023
Early detection of gallbladder cancer is difficult with poor prognosis in late stage. Although radical surgical treatment is the main method to cure gallbladder cancer at present, only less patients have radical surgery clinically.
WANG Yuanjiang, ZOU Hao
doaj   +1 more source

A Case of Early-Stage Gallbladder Cancer, Positive for ALDH1A1, Which Arose from Adenomyomatosis of the Gallbladder

Diagnostics, 2022
Adenomyomatosis (ADM) of the gallbladder is a condition characterized by the proliferation of Rokitansky–Aschoff sinus (RAS), in which the epithelium of the gallbladder extends into the muscular layer, causing a thickening of the gallbladder wall ...
Yuhei Iwasa, Keisuke Iwata, Mitsuru Okuno, Akihiko Sugiyama, Yoichi Nishigaki, Yosuke Ohashi, Takuji Tanaka, Takuji Iwashita, Masahito Shimizu, Eiichi Tomita   +9 more
doaj   +1 more source

Human Gallbladder Cancer Organoids. [PDF]

Cell Prolif
This guideline provides standardized requirements and quality control measures for human gallbladder cancer organoids, supporting their reliable application in research and precision medicine. It aims to promote methodological consistency, facilitate international collaboration, and accelerate translational research and clinical implementation.
Xiang D, Gong T, Zhu Y, Jia B, Zhang C, Tang N, Wang W, Wang Y, Zhong L, Zou Y, Zhang J, Zhou Z, Xing L, Zhou C, Zhu D, Liu Z, Chen G, Wang X, Wang Z, He A, Wang Y, Liu Z, Wang J, Xu F, Gao G, Kang X, Gong S, Kong X, Dong C, Ma A, Niu G, Wei G, Zhao H, Lu X, Cao J, Zhao T, Zhang Z, Liu Y.   +37 more
europepmc   +2 more sources

IGF2BP3 drives gallbladder cancer progression by m6A-modified CLDN4 and inducing macrophage immunosuppressive polarization

Translational Oncology, 2023
Introduction: N6-methyladenosine (m6A) is an emerging epigenetic modification, which plays a crucial role in the development of cancer. Nevertheless, the underlying mechanism of m6A-associated proteins and m6A modification in gallbladder cancer remains ...
Jian Qin, Zheng Cui, Jingyi Zhou, Bosen Zhang, Ruiqi Lu, Youcheng Ding, Hai Hu, Jingli Cai   +7 more
doaj   +1 more source

XRCC1 Is a Promising Predictive Biomarker and Facilitates Chemo-Resistance in Gallbladder Cancer

Frontiers in Molecular Biosciences, 2020
Gallbladder cancer is a relatively uncommon human malignant tumor with an extremely poor prognosis. Currently, no biomarkers can accurately diagnose gallbladder cancer and predict patients’ prognosis.
Zhengchun Wu, Xiongying Miao, Yuanfang Zhang, Daiqiang Li, Qiong Zou, Yuan Yuan, Rushi Liu, Zhulin Yang   +7 more
doaj   +1 more source

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source