Results 41 to 50 of about 10,899 (256)

Game Addiction and Smartphone Dependence: Influences of Affects and Loneliness

Avances en Psicología Latinoamericana
This study examined the relationships among smartphone dependence, online game addiction, affects, and loneliness, testing affects as mediators. Participants were 459 online multiplayer gamers aged 18 to 60 years who completed measures of smartphone ...
Layrtthon Carlos de Oliveira Santos, José Ryan Lopes Cabral, Anderson Mesquita do Nascimento, Washington Allysson Dantas Silva, Tailson Evangelista Mariano, Jéssica Alves da Costa   +5 more
doaj   +1 more source

Prestasi Belajar Siswa Ditinjau Dari Kecanduan Game Online dan Motivasi Belajar

Psychocentrum Review, 2021
The low student achievement is indicated because it is influenced by the level of game online and students learning motivation. The purposes of this study are 1) to determine the effect of online game addiction and learning motivation on learning ...
Briti Nursita, Yansen Alberth Reba, Sirjon Sirjon   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The impact of video game addiction on aggressive behaviour among tertiary students in Sri Lanka

Discover Education
This research examines the impact of video game addiction on aggressive behaviour of tertiary students in Sri Lanka. Video game addiction, with its potential adverse impacts has raised concerns among the public, especially regarding its link to ...
Warnage Yasanthi Sandamini Fonseka, Buddhika Madhubashini Hathurusinghe, Ranitha Sachinthana Weerarathna, Rathnayake Mudiyanselage Nilmini Malkanthi Rathnayake, Hewa Rathgamage Thisaru Samindika, Lahiru Thilina Dilshan Ramasingha, Nipunee Udarika Jayasuriya, Chathurini Kumarapperuma, Nirmani Dayapathirana   +8 more
doaj   +1 more source

More grateful, less addicted! Understanding how gratitude affects online gaming addiction among Chinese college students: a three-wave multiple mediation model

BMC Psychology, 2023
Background Online game addiction has become a prominent public concern, particularly among emerging adults, warranting in-depth investigation. Despite prior cross-sectional research indicating a negative correlation between gratitude and online gaming ...
Bin Gao, Yi Xu, Lu Bai, Gui Luo, Weiyi Li   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Hubungan antara Kecanduan Game Internet dengan Keterampilan Sosial pada Remaja di Kota Yogyakarta

Jurnal Keperawatan Klinis dan Komunitas (Clinical and Community Nursing Journal), 2022
Background: Most Indonesians are internet users. Adolescents, who are active internet users and use internet for playing game too often, have the risk of experiencing online gaming addiction. Internet game addict may possess poor social skills. Objective:
Devina Ngeksi Hari Laksono, Heru Subekti, Ema Madyaningrum   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source