Results 71 to 80 of about 123,631 (306)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Hubungan Stres dengan Tingkat Kecanduan Game Online pada Siswa SMPN 5 Padang

Jurnal Ilmu Kesehatan Indonesia, 2021
Background. Stress is a mental health disorder that often occurs. Stress is due to physical and psychological imbalances in dealing with pressures in daily life. Adolescents are highly sensitive stage of human development in dealing with stress.
Estiayuning Tias, Rini Gusya Liza, Roni Eka Sahputra   +2 more
doaj   +1 more source

Utility of Parental Mediation Model on Youth’s Problematic Online Gaming [PDF]

, 2015
The Parental Mediation Model PMM) was initially designed to regulate children’s attitudes towards the traditional media. In the present era, because of prevalent online media there is a need for similar regulative measures.
A Daud, A Kapahi, A Nathanson, AI Nathanson, AK Liau, BM Byrne, D Hooper, DA Fisher, DTL Shek, G Mesch, HF Kaiser, JF Hair, LA Kirkpatrick, M Buijzen, M Buijzen, M Teimori, Mark D. Griffiths, Misha Teimouri, MO Lwin, NAM Zin, P Nikken, PM Valkenburg, Rahim Benrazavi, RB Kline, S-J Lee, S-J Lee, Y Fujioka, Z Demetrovics   +27 more
core   +1 more source

Online Gaming Addiction? Motives Predict Addictive Play Behavior in Massively Multiplayer Online Role-Playing Games [PDF]

Cyberpsychology, Behavior, and Social Networking, 2012
Recently, there have been growing concerns about excessive online gaming. Playing Massively Multiplayer Online Role-Playing Games (MMORPGs) appears to be particularly problematic, because these games require a high degree of commitment and time investment from the players to the detriment of occupational, social, and other recreational activities and ...
Kuss, DJ, Louws, J, Wiers, RW
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Perbedaan Prestasi belajar Pada Siswa dengan Adiksi, Adiksi Ringan, dan Non-Adiksi Game online di SMAN 15 Padang

Jurnal Ilmu Kesehatan Indonesia
Abstrak Latar Belakang: Adiksi game online adalah kecanduan dalam memainkan game online dan paling banyak terjadi pada usia remaja, serta dapat mempengaruhi prestasi belajar.
Bunga Astuti, Rini Gusya Liza, Husnil Kadri   +2 more
doaj   +1 more source

KECANDUAN GAME ONLINE SEBAGAI SUMBER INSPIRASI [PDF]

, 2015
“Kecanduan Game Online sebagai Sumber Inspirasi”. Dipilih sebagai judul skrip karya karena dilihat dari besarnya pengaruh game online ini terhadap masa depan anak-anak dan remaja yang kini semakin menjamur diberbagai daerah.
I Wayan, Sutrisna
core  

Core and Peripheral Criteria of Video Game Addiction in the Game Addiction Scale for Adolescents [PDF]

Cyberpsychology, Behavior, and Social Networking, 2015
Assessment of video game addiction often involves measurement of peripheral criteria that indicate high engagement with games, and core criteria that indicate problematic use of games. A survey of the Norwegian population aged 16-74 years (N=10,081, response rate 43.6%) was carried out in 2013, which included the Gaming Addiction Scale for Adolescents (
Brunborg, Geir Scott, Hanss, Daniel, Mentzoni, Rune Aune, Pallesen, Ståle   +3 more
openaire   +4 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Online game addiction in adolescent: What should school counselor do?

Jurnal Konseling dan Pendidikan, 2019
Online game addiction in adolescents has become one of the problems that get a lot of public attention. Increasingly developing of technology, easy access and lack of comprehension of adolescents towards the dangers of online game addiction are some of ...
Eryzal Novrialdy, Rozi Atyarizal
doaj   +1 more source