Results 41 to 50 of about 20,311 (265)

A Schema Theory Analysis of The Game Character Eunie From ‘Xenoblade Chronicles 3’

Arbitrer
This article examines the activation of a schema based on the game, the realization of the Schema Theory in the game character named Eunie, and the proof of Eunie’s status as the primary character in the game. The study analyzes the factors that trigger
Agung Olaf Ridho Rambe, Rahmadsyah Rangkuti   +1 more
doaj   +1 more source

ETNOMATEMATIKA DAN NILAI KARAKTER DALAM PERMAINAN TRADISIONAL KEBETUK

Aksioma: Jurnal Program Studi Pendidikan Matematika, 2021
Traditional games are one of the cultural wealth in Indonesia. Along with the times and modernization, some traditional games are getting less and less attractive despite their national character values and benefits in increasing children's potential. To
Yuliana Olga Siba Sabon, Nur Hidayanto Pancoro Setyo Putro, Abdul Rahim   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Cag-Cag Folk Games as Media to Strengthening Mutual Cooperation Character of Elementary School Students

Indonesian Values and Character Education Journal, 2023
Individualism during group learning is a problem to be solved as it harms the mutual cooperation character of elementary school students. Therefore, this research aimed to analyze the effect of the Cag-cag folk game on strengthening the character of ...
Komang Ayu Tantri Sastra Dewi, Anak Agung Gede Agung, Ida Bagus Gede Surya Abadi   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PENERAPAN LOGIKA FUZZY SUGENO UNTUK PENENTUAN REWARD PADA GAME EDUKASI AKU BISA

JUTI: Jurnal Ilmiah Teknologi Informasi, 2019
This study discusses an application of fuzzy logic in educational game. This game requires a fast player response. We made this game in order to raise children awareness to encounter strangers.
Chaulina Alfianti Oktavia, Rakhmad Maulidi   +1 more
doaj   +1 more source

GAME PANJOL BERBASIS ANDROID UNTUK MENINGKATKAN KARAKTER BERSAHABAT PADA SISWA SEKOLAH DASAR

Refleksi Edukatika, 2021
The purpose of this study was to determine the increase in friendly character in elementary school students after learning to use the Panjol game. The research method used is the experimental research method.
Much Arsyad Fardani, Ika Ari Pratiwi, Zuhdan Kun Prasetyo, Samsuri Samsuri, Tutik Khotimah   +4 more
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source