Results 101 to 110 of about 4,498,628 (333)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Translating board games: multimodality anad play

open access: yesJoSTrans: The Journal of Specialised Translation, 2013
This article examines the translation of modern board games as multimodal texts. It argues that games are produced in the interaction between players, pieces and rules, making them a participatory form of text.
Jonathan Evans
doaj   +1 more source

Element Enterprise Tycoon: Playing Board Games to Learn Chemistry in Daily Life

open access: yesEducation Sciences, 2020
This article reports the design of a scientific board game, named “Element Enterprise Tycoon” (EET), which creates a scenario combining chemical elements, techniques, and products in daily life.
Jen-Che Tsai   +3 more
doaj   +1 more source

Fictional game elements 2016 [PDF]

open access: yes, 2017
Gamification has been widely accepted in the HCI community in the last few years. However, the current debate is focused on its short-term consequences, such as effectiveness and usefulness, while its side-effects, long-term criticalities and systemic ...
Cena, Federica   +4 more
core  

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

open access: yesFEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman   +4 more
wiley   +1 more source

PEMBUATAN KARAKTER DAN LINGKUNGAN GAME MENGGUNAKAN KONSEP FOUR BASIC ELEMENTS “Game Petualangan Pangeran Jawa Barat” [PDF]

open access: yes, 2018
Four Basic Elements adalah empat elemen dasar yang membentuk sebuah game terutama dalam pembuatan karakter dan lingkungan dengan menekankan keterkaitan elements sroty, elements mechanics, elements aesthetic, elements technology.
Dwiki Ramadhan, 133040121
core  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Digital game elements, user experience and learning: A conceptual framework

open access: yesEducation and Information Technologies : Official Journal of the IFIP technical committee on Education, 2018
The primary aim of this paper is to identify and theoretically validate the relationships between core game design elements and mechanics, user motivation and engagement and consequently learning.
Andreas Alexiou, M. Schippers
semanticscholar   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon   +12 more
wiley   +1 more source

Game-based learning environments affect frontal brain activity.

open access: yesPLoS ONE, 2020
Inclusion of game elements in learning environments to increase motivation and learning outcome is becoming increasingly popular. However, underlying mechanisms of game-based learning have not been studied sufficiently yet.
Silvia Erika Kober   +4 more
doaj   +1 more source

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