Results 31 to 40 of about 1,363,895 (292)

CAD-game engine approach in developing real-world walkthrough VR application [PDF]

open access: yes, 2003
The use of 3D Game Engines to create real-world Walkthrough-Virtual Reality (VR) applications is a promising new alternative to currently available commercial VR packages.
Shiratuddin, M.F., Zulkifli, A.N.
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Unifying Rigid and Soft Bodies Representation: The Sulfur Physics Engine

open access: yesInternational Journal of Computer Games Technology, 2014
Video games are (also) real-time interactive graphic simulations: hence, providing a convincing physics simulation for each specific game environment is of paramount importance in the process of achieving a satisfying player experience.
Dario Maggiorini   +2 more
doaj   +1 more source

Utilization of open-source game engines for the description of construction systems suited to self-building

open access: yesTechne, 2019
This article explores the possibility of utilizing a game engine to support the description of construction solutions aimed to self-builders. The results of this experimentation strengthen the hypothesis that game engines would worth to be made a part of
Gian Luca Brunetti
doaj   +1 more source

Utilizing a 3D game engine to develop a virtual design review system [PDF]

open access: yes, 2011
A design review process is where information is exchanged between the designers and design reviewers to resolve any potential design related issues, and to ensure that the interests and goals of the owner are met. The effective execution of design review
Thabet, W., Shiratuddin, M.F.
core  

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

First Steps in the Use of a Game Engine for Historical Roads and Paths Research

open access: yesJournal of Computer Applications in Archaeology, 2019
Game engines are developing fast and are used in several scientific disciplines. In the domain of cultural heritage, they have been applied mostly for dynamic visualization.
Willem Vletter
doaj   +1 more source

Design Foundations for Emotional Game Characters

open access: yesEludamos, 2020
Recent Computer Role Playing Games such as Bethesda’s The Elder Scrolls V: Skyrim and Nintendo’s The Legend of Zelda: Breath of the Wild, have entranced us with their expansive, complex worlds.
Geneva Smith, Jacques Carette
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

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