Results 41 to 50 of about 893,285 (266)

Solving “Smart City” Transport Problems by Designing Carpooling Gamification Schemes with Multi-Agent Systems: The Case of the So-Called “Mordor of Warsaw”

Sensors, 2018
To reduce energy consumption and improve residents’ quality of life, “smart cities” should use not only modern technologies, but also the social innovations of the “Internet of Things” (IoT) era.
Robert Olszewski, Piotr Pałka, Agnieszka Turek   +2 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Video Games as a Response to Socio-Political Processes and Events in Serbia

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The socio-political landscape in Serbia has been marked by a series of crises, protests, and turbulent events in recent years. In such an environment, video games have increasingly emerged as a form of response to current developments, creating digital ...
Irena Čučković, Manojlo Maravić
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Expert-Driven (Online) Game Jams for (Game) Design Education

, 2021
In this paper, we explore a teaching experiment utilizing expert-driven online game jams in the context of game design education. Four online game jams were run as a part of an open lecture series on game development between March 2020 and April 2021 ...
Laura Piispanen, Tomi Kauppinen, Solip Park, Kankainen, Ville, Riikka Aurava, Ville Kankainen, Annakaisa Kultima, Piispanen, Laura, Kultima, Annakaisa, Park, Solip, Kauppinen, Tomi, Aurava, Riikka   +11 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Game Jams: novos lugares educativos? ,

Educação e Pesquisa, 2023
Resumo A existência de vários lugares para o educativo está sendo reconhecida na sociedade contemporânea. As game jams (GJ), contextos de criação de videojogos, vêm sendo estudadas como lugares onde o educativo pode ser emergente. Este artigo apresenta uma revisão da literatura, que integra estudos acerca das relações entre game jams e educação. Poucos
Lucinda Saldanha, Sofia Marques da Silva, Pedro D. Ferreira   +2 more
openaire   +3 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Game Jams: How can they influence Software Development Curricula? [PDF]

This paper will present an ongoing project which is attempting to capture the ethos of game jam participation and its inherent educational benefits applying these outcomes to rejuvenate and influence the delivery of Software Engineering ...
Law, Robert, McDonald, Brian
core   +7 more sources