Results 91 to 100 of about 14,920 (249)

A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model

eLife, 2018
Background: Malaria elimination strategies require a thorough understanding of parasite transmission from human to mosquito. A clinical model to induce gametocytes to understand their dynamics and evaluate transmission-blocking interventions (TBI) is ...
Isaie J Reuling, Lisanne A van de Schans, Luc E Coffeng, Kjerstin Lanke, Lisette Meerstein-Kessel, Wouter Graumans, Geert-Jan van Gemert, Karina Teelen, Rianne Siebelink-Stoter, Marga van de Vegte-Bolmer, Quirijn de Mast, André J van der Ven, Karen Ivinson, Cornelus C Hermsen, Sake de Vlas, John Bradley, Katharine A Collins, Christian F Ockenhouse, James McCarthy, Robert W Sauerwein, Teun Bousema   +20 more
doaj   +1 more source

Real-time PCR assays for detection and quantification of early P. falciparum gametocyte stages

Scientific Reports, 2021
The use of quantitative qRT-PCR assays for detection and quantification of late gametocyte stages has revealed the high transmission capacity of the human malaria parasite, Plasmodium falciparum. To understand how the parasite adjusts its transmission in
Amal A. H. Gadalla, Giulia Siciliano, Ryan Farid, Pietro Alano, Lisa Ranford-Cartwright, James S. McCarthy, Joanne Thompson, Hamza A Babiker   +7 more
doaj   +1 more source

Coordinated regulation of gene expression in Plasmodium female gametocytes by two transcription factors [PDF]

, 2023
Yuho Murata, Tsubasa Nishi, Izumi Kaneko, Shiroh Iwanaga, Masao Yuda   +4 more
openalex   +1 more source

A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum

Angewandte Chemie International Edition, Volume 64, Issue 49, December 1, 2025.
Compound 31 represents a promising avenue for the development as an antimalarial agent with a potent activity profile (PfNF54 IC50 ± s.d. = 3.9 ± 0.4 nM). It has a novel mode of action by binding to cytosolic ribosomal subunits, thereby inhibiting protein synthesis in the parasite.
Patricia Bravo, Eleonora Diamanti, Mostafa M. Hamed, Lorenzo Bizzarri, Natalie Wiedemar, Armin Passecker, Nicolas M. B. Brancucci, Anna Albisetti, Christin Gumpp, Boris Illarionov, Markus Fischer, Matthias Witschel, Tobias Schehl, Hannes Hahne, Pascal Mäser, Matthias Rottmann, Anna K. H. Hirsch   +16 more
wiley   +1 more source

Tandem Mass Spectrometry and Bio‐Guided Isolation of Secondary Metabolites With Antiplasmodial Activity From Dalbergia miscolobium Bark

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Strategies have been employed to address antimalarial drug resistance, including the exploration of new therapeutic targets. In this study, the stem bark of Dalbergia miscolobium was investigated using in vitro assays against Plasmodium falciparum and pyruvate kinase II (PyrKII), an essential enzyme for parasite development.
Thais Bertolino Vieira Dantas, Igor M. R. Moura, Romário Pereira da Costa, Guilherme Eduardo de Souza, Richele Priscila Severino, Hélder Nagai Consolaro, Luis Felipe de Oliveira, Vinicius Bonatto, Quezia Bezerra Cass, Rafael V. C. Guido, Lorena Ramos Freitas de Sousa   +10 more
wiley   +1 more source

Clinical value of clinician‐ordered pathologist‐reviewed peripheral blood smears in a teaching hospital

Precision Medical Sciences, Volume 14, Issue 4, Page 160-167, December 2025.
This study highlights the essential yet selective role of PBS in modern hematology, particularly in diagnosing WBC abnormalities and hematologic malignancies. Abstract Peripheral blood smear (PBS) review is a test performed to evaluate a wide variety of hematologic and non‐hematologic disorders.
Mohammad Hossein Anbardar, Hamid Zaferani Arani, Fatemeh Tashakori Bafghi, Najmeh Zolmajdi, Sadegh Masjoodi   +4 more
wiley   +1 more source

Quantification of sporozoite expelling by Anopheles mosquitoes infected with laboratory and naturally circulating P. falciparum gametocytes

eLife
It is currently unknown whether all Plasmodium falciparum-infected mosquitoes are equally infectious. We assessed sporogonic development using cultured gametocytes in the Netherlands and naturally circulating strains in Burkina Faso.
Chiara Andolina, Wouter Graumans, Moussa Guelbeogo, Geert-Jan van Gemert, Jordache Ramijth, Soré Harouna, Zongo Soumanaba, Rianne Stoter, Marga Vegte-Bolmer, Martina Pangos, Photini Sinnis, Katharine Collins, Sarah G Staedke, Alfred B Tiono, Chris Drakeley, Kjerstin Lanke, Teun Bousema   +16 more
doaj   +1 more source

Modeling the impact of Plasmodium falciparum sexual stage immunity on the composition and dynamics of the human infectious reservoir for malaria in natural settings.

PLoS Pathogens, 2018
Malaria transmission remains high in Sub-Saharan Africa despite large-scale implementation of malaria control interventions. A comprehensive understanding of the transmissibility of infections to mosquitoes may guide the design of more effective ...
André Lin Ouédraogo, Philip A Eckhoff, Adrian J F Luty, Will Roeffen, Robert W Sauerwein, Teun Bousema, Edward A Wenger   +6 more
doaj   +1 more source

New Evidence of TLR4 and TLR9 Variants Influencing Parasitaemia and Symptoms of Plasmodium vivax Infection

International Journal of Immunogenetics, Volume 52, Issue 6, Page 371-378, December 2025.
ABSTRACT Toll‐like receptors (TLRs) induce the production of pro‐inflammatory cytokines and regulate the immune response to Plasmodium vivax infection. Genetic variants of TLRs are associated with susceptibility and severity of malaria in different populations. This study aimed to evaluate the association between polymorphisms in TLR1, TLR4, TLR7, TLR8,
Mikaele Monik Rodrigues Inácio Silva, Gabriela Maria Andrade Correia, Juliana Dal‐Ri Lindenau, Maristela Gomes Cunha, Maria Deise Oliveira Ohnishi, Ana Maria Revoredo Silva Ventura, Ândrea Ribeiro‐dos‐Santos, Mara Helena Hutz, Vinicius Albuquerque Sortica   +8 more
wiley   +1 more source

Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity [PDF]

, 2018
Infection with Plasmodium can elicit antibodies that inhibit parasite survival in the mosquito, when they are ingested in an infectious blood meal. Here, we determine the transmission-reducing activity (TRA) of naturally acquired antibodies from 648 ...
Bousema, Teun, Bradley, John, Campo, Joseph J., Cohuet, Anna, Da, Dari, de Jong, Roos M., Drakeley, Chris, Fabra-García, Amanda, Felgner, Phil, Graumans, Wouter, Gremo, Giuliana, Janse, Chris J., Jones, Sophie, Jore, Matthijs M., Lanke, Kjerstin, Lasonder, Edwin, Marti, Matthias, Meerstein-Kessel, Lisette, Morlais, Isabelle, Nsango, Sandrine, Ouédraogo, André Lin, Pablo, Jozelyn V., Roeffen, Will, Sauerwein, Robert, Schwarzer, Evelin, Shandling, Adam D., Siebelink-Stoter, Rianne, Singh, Susheel K., Stone, Will J. R., Sutherland, Colin J., Teng, Andy A., Theisen, Michael, van de Vegte-Bolmer, Marga, van Gemert, Geert-Jan   +33 more
core   +17 more sources