Results 21 to 30 of about 14,920 (249)

Predicting the likelihood and intensity of mosquito infection from sex specific Plasmodium falciparum gametocyte density

eLife, 2018
Understanding the importance of gametocyte density on human-to-mosquito transmission is of immediate relevance to malaria control. Previous work (Churcher et al., 2013) indicated a complex relationship between gametocyte density and mosquito infection ...
John Bradley, Will Stone, Dari F Da, Isabelle Morlais, Alassane Dicko, Anna Cohuet, Wamdaogo M Guelbeogo, Almahamoudou Mahamar, Sandrine Nsango, Harouna M Soumaré, Halimatou Diawara, Kjerstin Lanke, Wouter Graumans, Rianne Siebelink-Stoter, Marga van de Vegte-Bolmer, Ingrid Chen, Alfred Tiono, Bronner Pamplona Gonçalves, Roland Gosling, Robert W Sauerwein, Chris Drakeley, Thomas S Churcher, Teun Bousema   +22 more
doaj   +1 more source

Development of reverse-transcription PCR techniques to analyse the density and sex ratio of gametocytes in genetically diverse Plasmodium chabaudi infections [PDF]

, 2007
We have developed cross-genotype and genotype-specific quantitative reverse-transcription PCR (qRT-PCR) assays to detect and quantify the number of parasites, transmission stages (gametocytes) and male gametocytes in blood stage Plasmodium chabaudi ...
Abdel-Wahab, Alano, Babiker, Bell, Cheeseman, Damien R. Drew, De Roode, De Roode, De Roode, Dye, Ferguson, Ferguson, Foster, Gardner, Gautret, Hamilton, Khan, Mackinnon, Nee, Paterson, Paul, Paul, Paul, Pinheiro, Ranford-Cartwright, Read, Read, Read, Reece, Reece, Reece, Sarah E. Reece, Schall, Schall, Schneider, Shutler, Sinden, Taylor, Taylor, Wargo, Wargo, West, West, West, West   +44 more
core   +1 more source

PfARID Regulates P. falciparum Malaria Parasite Male Gametogenesis and Female Fertility and Is Critical for Parasite Transmission to the Mosquito Vector

mBio, 2022
Sexual reproduction of Plasmodium falciparum parasites is critical to the spread of malaria in the human population. The factors that regulate gene expression underlying formation of fertilization-competent gametes, however, remain unknown.
Sudhir Kumar, Vinay K. Baranwal, Meseret T. Haile, Kenza M. Z. Oualim, Biley A. Abatiyow, Spencer Y. Kennedy, Ashley M. Vaughan, Stefan H. I. Kappe   +7 more
doaj   +1 more source

Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials. [PDF]

, 2008
BACKGROUND: Artemisinin combination therapies (ACT), which are increasingly being introduced for treatment of Plasmodium falciparum malaria, are more effective against sexual stage parasites (gametocytes) than previous first-line antimalarials and ...
Bousema, Teun, Drakeley, Chris J, Ghani, Azra C, Okell, Lucy C, Sutherland, Colin J   +4 more
core   +3 more sources

Low Levels of Human Antibodies to Gametocyte-Infected Erythrocytes Contrasts the PfEMP1-Dominant Response to Asexual Stages in P. falciparum Malaria

Frontiers in Immunology, 2019
Vaccines that target Plasmodium falciparum gametocytes have the potential to reduce malaria transmission and are thus attractive targets for malaria control. However, very little is known about human immune responses to gametocytes present in human hosts.
Jo-Anne Chan, Damien R. Drew, Linda Reiling, Ashley Lisboa-Pinto, Bismarck Dinko, Colin J. Sutherland, Arlene E. Dent, Kiprotich Chelimo, James W. Kazura, Michelle J. Boyle, James G. Beeson, James G. Beeson, James G. Beeson   +12 more
doaj   +1 more source

Rosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis

Frontiers in Cellular and Infection Microbiology, 2023
Plasmodium vivax is a public health problem and the most common type of malaria outside sub-Saharan Africa. The capacity of cytoadhesion, rosetting, and liver latent phase development could impact treatment and disease control. Although the ability to P.
Luis Carlos Salazar Alvarez, Luis Carlos Salazar Alvarez, Luis Carlos Salazar Alvarez, Vanessa Carneiro Barbosa, Vanessa Carneiro Barbosa, Omaira Vera Lizcano, Omaira Vera Lizcano, Omaira Vera Lizcano, Djane Clarys Baia da Silva, Djane Clarys Baia da Silva, Djane Clarys Baia da Silva, Djane Clarys Baia da Silva, Djane Clarys Baia da Silva, Rosa Amélia Gonçalves Santana, Rosa Amélia Gonçalves Santana, Rosa Amélia Gonçalves Santana, Camila Fabbri, Camila Fabbri, Camila Fabbri, Paulo Filemon Paoluci Pimenta, Paulo Filemon Paoluci Pimenta, Paulo Filemon Paoluci Pimenta, Wuelton Marcelo Monteiro, Wuelton Marcelo Monteiro, Letusa Albrecht, Letusa Albrecht, Marcus Vinicius Guimarães de Lacerda, Marcus Vinicius Guimarães de Lacerda, Marcus Vinicius Guimarães de Lacerda, Fabio Trindade Maranhão Costa, Fabio Trindade Maranhão Costa, Stefanie Costa Pinto Lopes, Stefanie Costa Pinto Lopes, Stefanie Costa Pinto Lopes   +33 more
doaj   +1 more source

The Plasmodium falciparum, Nima-related kinase Pfnek-4: a marker for asexual parasites committed to sexual differentiation [PDF]

, 2012
<b>Background</b> Malaria parasites undergo, in the vertebrate host, a developmental switch from asexual replication to sexual differentiation leading to the formation of gametocytes, the only form able to survive in the mosquito vector ...
AG Maier, AM Talman, Andrew Tomlins, C Aurrecoechea, Christian Doerig, CJ Tonkin, EK De Silva, F Silvestrini, J Miao, JA Braks, KG Le Roch, L O’Regan, L Reininger, L Reininger, L Reininger, LM Quarmby, Luc Reininger, M Dyer, MC Bruce, Miguel Garcia, N Hall, P Alano, R Carter, RE Sinden, S Eksi, S Singh, SM Khan, Sylke Müller   +27 more
core   +6 more sources

Biology of Plasmodium falciparum gametocyte sex ratio and implications in malaria parasite transmission

Malaria Journal, 2019
While significant advances have been made in understanding Plasmodium falciparum gametocyte biology and its relationship with malaria parasite transmission, the gametocyte sex ratio contribution to this process still remains a relevant research question.
Noëlie Béré Henry, Samuel Sindié Sermé, Giulia Siciliano, Salif Sombié, Amidou Diarra, N’fale Sagnon, Alfred S. Traoré, Sodiomon Bienvenu Sirima, Issiaka Soulama, Pietro Alano   +9 more
doaj   +1 more source

Demographical, hematological and serological risk factors for Plasmodium falciparum gametocyte carriage in a high stable transmission zone in Cameroon.

PLoS ONE, 2019
Presence of mature gametocyte forms of malaria parasites in peripheral blood is a key requirement for malaria transmission. Yet, studies conducted in most malaria transmission zones report the absence of gametocyte in the majority of patients.
Estelle Essangui, Carole Else Eboumbou Moukoko, Niels Nguedia, Michele Tchokwansi, Umaru Banlanjo, Franklin Maloba, Balotin Fogang, Christiane Donkeu, Marie Biabi, Glwadys Cheteug, Sylvie Kemleu, Emmanuel Elanga-Ndille, Léopold Lehman, Lawrence Ayong   +13 more
doaj   +1 more source

Pleiotropic Roles for the Plasmodium berghei RNA Binding Protein UIS12 in Transmission and Oocyst Maturation

Frontiers in Cellular and Infection Microbiology, 2021
Colonization of the mosquito host by Plasmodium parasites is achieved by sexually differentiated gametocytes. Gametocytogenesis, gamete formation and fertilization are tightly regulated processes, and translational repression is a major regulatory ...
Katja Müller, Katja Müller, Olivier Silvie, Hans-Joachim Mollenkopf, Kai Matuschewski, Kai Matuschewski   +5 more
doaj   +1 more source