Results 21 to 30 of about 7,720 (145)

Pleiotropic Roles for the Plasmodium berghei RNA Binding Protein UIS12 in Transmission and Oocyst Maturation

Frontiers in Cellular and Infection Microbiology, 2021
Colonization of the mosquito host by Plasmodium parasites is achieved by sexually differentiated gametocytes. Gametocytogenesis, gamete formation and fertilization are tightly regulated processes, and translational repression is a major regulatory ...
Katja Müller, Katja Müller, Olivier Silvie, Hans-Joachim Mollenkopf, Kai Matuschewski, Kai Matuschewski   +5 more
doaj   +1 more source

Quantifying Reductions in Plasmodium falciparum Infectivity to Mosquitos: A Sample Size Calculator to Inform Clinical Trials on Transmission-Reducing Interventions

Frontiers in Immunology, 2022
Malaria transmission depends on the presence of mature Plasmodium transmission stages (gametocytes) that may render blood-feeding Anopheles mosquitos infectious.
Jordache Ramjith, Jordache Ramjith, Manon Alkema, John Bradley, Alassane Dicko, Chris Drakeley, Will Stone, Teun Bousema   +7 more
doaj   +1 more source

Concentration of Plasmodium falciparum gametocytes in whole blood samples by magnetic cell sorting enhances parasite infection rates in mosquito feeding assays

Malaria Journal, 2017
Background Mosquito-feeding assays are important tools to guide the development and support the evaluation of transmission-blocking interventions. These functional bioassays measure the sporogonic development of gametocytes in blood-fed mosquitoes ...
Isaie J. Reuling, Will J. R. Stone, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Rianne Siebelink-Stoter, Wouter Graumans, Kjerstin Lanke, Teun Bousema, Robert W. Sauerwein   +8 more
doaj   +1 more source

Anti-Gametocyte Antigen Humoral Immunity and Gametocytemia During Treatment of Uncomplicated Falciparum Malaria: A Multi-National Study

Frontiers in Cellular and Infection Microbiology, 2022
IntroductionUnderstanding the human immune response to Plasmodium falciparum gametocytes and its association with gametocytemia is essential for understanding the transmission of malaria as well as progressing transmission blocking vaccine candidates ...
Katherine O’Flaherty, Jo-Anne Chan, Jo-Anne Chan, Jo-Anne Chan, Julia C. Cutts, Julia C. Cutts, Sophie G. Zaloumis, Elizabeth A. Ashley, Elizabeth A. Ashley, Aung Pyae Phyo, Damien R. Drew, Arjen M. Dondorp, Arjen M. Dondorp, Nicholas P. Day, Nicholas P. Day, Mehul Dhorda, Mehul Dhorda, Mehul Dhorda, Rick M. Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tran Tinh Hien, Tran Tinh Hien, Ye Htut, Mayfong Mayxay, Mayfong Mayxay, Mayfong Mayxay, M. Abul Faiz, Olugbenga A. Mokuolu, Marie A. Onyamboko, Caterina Fanello, Caterina Fanello, Caterina Fanello, Eizo Takashima, Takafumi Tsuboi, Michael Theisen, Michael Theisen, Francois Nosten, Francois Nosten, Francois Nosten, James G. Beeson, James G. Beeson, James G. Beeson, James G. Beeson, Julie A. Simpson, Nicholas J. White, Nicholas J. White, Freya J. I. Fowkes, Freya J. I. Fowkes, Freya J. I. Fowkes   +50 more
doaj   +1 more source

Transmission immunity in malaria: reflections on the underlying immune mechanisms during natural infections and following artificial immunization

Memorias do Instituto Oswaldo Cruz, 1992
Malaria transmission-blocking immunity has been studied in natural malaria infections in man, during infections in animals and following artificial immunization of animals with sexual stage malaria parasites.
Richard Carter, Kamini Mendis
doaj   +1 more source

Blood-Stage Parasitaemia and Age Determine Plasmodium falciparum and P. vivax Gametocytaemia in Papua New Guinea. [PDF]

PLoS ONE, 2015
A better understanding of human-to-mosquito transmission is crucial to control malaria. In order to assess factors associated with gametocyte carriage, 2083 samples were collected in a cross-sectional survey in Papua New Guinea.
Cristian Koepfli, Leanne J Robinson, Patricia Rarau, Mary Salib, Naomi Sambale, Rahel Wampfler, Inoni Betuela, Wang Nuitragool, Alyssa E Barry, Peter Siba, Ingrid Felger, Ivo Mueller   +11 more
doaj   +1 more source

Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs

Malaria Journal, 2010
Background There is renewed acknowledgement that targeting gametocytes is essential for malaria control and elimination efforts. Simple mathematical models were fitted to data from clinical trials in order to determine the mean gametocyte circulation ...
Sawa Patrick, Omar Sabah, Griffin Jamie T, Shekalaghe Seif, Okell Lucy, Bousema Teun, Sutherland Colin, Sauerwein Robert, Ghani Azra C, Drakeley Chris   +9 more
doaj   +1 more source

Differential infectivity of gametocytes after artemisinin-based combination therapy of uncomplicated falciparum malaria

African Journal of Laboratory Medicine, 2018
Background: Most malaria-endemic countries use artemisinin-based combination therapy (ACT) as their first-line treatment. ACTs are known to be highly effective on asexual stages of the malaria parasite.
Dinkorma T. Ouologuem, Cheick O. Kone, Bakary Fofana, Bakary Sidibe, Amadou H. Togo, Demba Dembele, Sekou Toure, Sekou Koumare, Ousmane Toure, Issaka Sagara, Abdoulaye Toure, Adama Dao, Ogobara K. Doumbo, Abdoulaye A. Djimde   +13 more
doaj   +1 more source

Ultrastructure and function of mitochondria in gametocytic stage of Plasmodium falciparum

Parasite, 2000
Morphological properties of the mitochondrial organelles in the asexual and sexual gametocytic stages of Plasmodium falciparum have been analyzed and found to be markedly different.
Krungkrai J., Prapunwattana P., Krungkrai S.R.   +2 more
doaj   +1 more source

Longitudinal impact of asymptomatic malaria/HIV-1 co-infection on Plasmodium falciparum gametocyte transcript expression and transmission to Anopheles mosquitoes

Frontiers in Cellular and Infection Microbiology, 2022
Despite significant developments towards malaria reduction, parasite transmission in the common context of HIV-1 co-infection and treatment for one or both infections has not been fully characterized.
Ashleigh Roberds, Carolyne Kifude, Janet Oyieko, Stephen Ocholla, James Mutunga, James Mutunga, David Oullo, Charles Waga, Zhaozhang Li, Shirley Luckhart, V. Ann Stewart   +10 more
doaj   +1 more source