Results 61 to 70 of about 14,920 (249)

Imaging malaria parasites across scales and time

Journal of Microscopy, EarlyView.
Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley   +1 more source

Persistent Plasmodium falciparum infections enhance transmission-reducing immunity development

Scientific Reports, 2021
Subclinical infections that serve as reservoir populations to drive transmission remain a hurdle to malaria control. Data on infection dynamics in a geographical area is required to strategically design and implement malaria interventions.
Ruth Ayanful-Torgby, Esther Sarpong, Hamza B. Abagna, Dickson Donu, Evans Obboh, Benedicta A. Mensah, Joshua Adjah, Kim C. Williamson, Linda E. Amoah   +8 more
doaj   +1 more source

Epidemiology of Malaria in an Area Prepared for Clinical Trials in Korogwe, North-eastern Tanzania. [PDF]

, 2009
Site preparation is a pre-requesite in conducting malaria vaccines trials. This study was conducted in 12 villages to determine malariometric indices and associated risk factors, during long and short rainy seasons, in an area with varying malaria ...
Acleus S Rutta, AE Mnzava, AM Ronn, Bruno P Mmbando, CA Maxwell, CJ Drakeley, CJ Drakeley, Deus S Ishengoma, DG Heppner Jr, E Kahigwa, Filbert Francis, H Dirren, Hamisi A Msangeni, J Keiser, JC Beier, JG Siri, JP Lusingu, JP Lusingu, JP Shott, KN Suh, M Alifrangis, Martha M Lemnge, Mathias L Kamugisha, Method D Segeja, Misago D Seth, PB Bloland, R Bodker, R Bodker, RW Snow, S Vyas, Samwel H Sembuche, V Robert, WL Kilama, WL Kilama   +33 more
core   +3 more sources

Artificial intelligence‐powered microscopy: Transforming the landscape of parasitology

Journal of Microscopy, EarlyView.
Abstract Microscopy and image analysis play a vital role in parasitology research; they are critical for identifying parasitic organisms and elucidating their complex life cycles. Despite major advancements in imaging and analysis, several challenges remain. These include the integration of interdisciplinary data; information derived from various model
Mariana De Niz, Sara Silva Pereira, David Kirchenbuechler, Leandro Lemgruber, Constadina Arvanitis   +4 more
wiley   +1 more source

Mass campaigns with antimalarial drugs: a modelling comparison of artemether-lumefantrine and DHA-piperaquine with and without primaquine as tools for malaria control and elimination

, 2015
Antimalarial drugs are a powerful tool for malaria control and elimination. Artemisinin-based combination therapies (ACTs) can reduce transmission when widely distributed in a campaign setting.
Eckhoff, Philip, Gerardin, Jaline, Wenger, Edward A.   +2 more
core   +1 more source

Strategies for Detection of Plasmodium species Gametocytes

PLoS ONE, 2013
Carriage and density of gametocytes, the transmission stages of malaria parasites, are determined for predicting the infectiousness of humans to mosquitoes. This measure is used for evaluating interventions that aim at reducing malaria transmission.
Wampfler, R, Mwingira, F, Javati, S, Robinson, L, Betuela, I, Siba, P, Beck, H-P, Mueller, I, Felger, I   +8 more
openaire   +6 more sources

Plasmodium falciparum Gametocyte Enrichment in Peripheral Blood Samples by Magnetic Fractionation: Gametocyte Yields and Possibilities to Reuse Columns [PDF]

The American Journal of Tropical Medicine and Hygiene, 2019
Gametocytes are sexual stage malaria parasites responsible for transmission to mosquitoes. Multiple gametocyte-producing clones may be present in natural infections, but the molecular characterization of gametocytes is challenging. Because of their magnetic properties, gametocyte enrichment can be achieved by magnetic fractionation.
Graumans, Wouter, Andolina, Chiara, Awandu, Shehu S., Grignard, Lynn, Lanke, Kjerstin, Bousema, Teun   +5 more
openaire   +5 more sources

Artemisinin‐Based Combination Therapies in East Africa: A Systematic Review of Quality, Clinical Efficacy, and Regulatory Progress Towards Sustainable Malaria Control

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background Malaria is a major public health issue in East Africa, leading to widespread illness and fatalities, especially among vulnerable populations such as children under 5 years of age and pregnant women. Artemisinin‐based combination therapies (ACTs) are the primary treatment modality; however, their efficacy is undermined by the ...
Yesuneh Tefera Mekasha, Addisu Afrassa Tegegne, Tapfumanei Mashe, Million Girma, Gemmechu Hasen, Sileshi Belew   +5 more
wiley   +1 more source

Plasmodium falciparum Spatial Analysis, Western Kenya Highlands

Emerging Infectious Diseases, 2005
We carried out a population-based study to determine the unbiased, age-specific Plasmodium falciparum prevalence, asexual and sexual parasite density, and spatial distribution to establish rates of infection at a site in western Kenya.
Otsyula G. Munyekenye, Andrew Githeko, Guofa Zhou, Emmanuel Mushinzimana, Noboru Minakawa, Guiyun Yan   +5 more
doaj   +1 more source

The Plasmodium falciparum CCCH Zinc Finger Protein ZNF4 Plays an Important Role in Gametocyte Exflagellation through the Regulation of Male Enriched Transcripts

Cells, 2022
CCCH zinc finger proteins (ZFPs) function mainly as RNA-binding proteins (RBPs) and play a central role in the mRNA metabolism. Over twenty seven CCCH-ZFPs are encoded in the genome of the human malaria parasite Plasmodium falciparum, the causative agent
Borja Hanhsen, Afia Farrukh, Gabriele Pradel, Che Julius Ngwa   +3 more
doaj   +1 more source