Results 81 to 90 of about 14,920 (249)
Members of the WD40-repeat protein family can be found in all eukaryotic proteomes where they usually serve as interaction platforms for the assembly of large protein complexes and are therefore essential for the integrity of these complexes.
Lena Roling +3 more
doaj +1 more source
Exploration of in Vivo Efficacy of Artemether-Lumefantrine Against Uncomplicated Plasmodium Falciparum Malaria in Under Fives in Tabora Region, Tanzania. [PDF]
Tanzania adopted artemether-lumefantrine (AL) as first-line drug for uncomplicated malaria in 2006. Recently, there was an anecdotal report on high malaria recurrence rate following AL treatment in in the (urban and peri-urban), western part of Tanzania.
Hulser, Ruth +5 more
core +3 more sources
This article presents a detailed ultrastructural cell atlas of Plasmodium ookinete development using advanced volume electron microscopy (v) techniques. It defines seven distinct developmental stages, revealing complex organelle interactions and offering new insights into parasite differentiation.
Nedal Darif +12 more
wiley +1 more source
Predominance of asymptomatic and sub-microscopic infections characterizes the Plasmodium gametocyte reservoir in the Peruvian Amazon. [PDF]
Malaria transmission requires that Anopheles mosquitoes ingest Plasmodium gametocyte stages circulating in the human bloodstream. In the context of malaria elimination, understanding the epidemiology of gametocytes relative to all Plasmodium infections ...
Eduard Rovira-Vallbona +8 more
doaj +1 more source
Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri +14 more
wiley +1 more source
South America has a remarkable genetic diversity of avian haemosporidians, yet only a few species have been described combining molecular and morphological data. This study introduces Plasmodium (Novyella) pyriglenae sp. nov., a new species infecting the white‐shouldered fire‐eye (Pyriglena leucoptera) in Brazil.
Luiz Gustavo Magalhães Alves +4 more
wiley +1 more source
Plasmodium falciparum gametocyte carriage in longitudinally monitored incident infections is associated with duration of infection and human host factors [PDF]
Chiara Andolina +16 more
openalex +1 more source
ABSTRACT A man aged in his 40s, recently returned from Uganda, was hospitalised with Plasmodium falciparum malaria, with hyperparasitaemia of ~1.5 × 106 parasites/μL (26%). He received intravenous artesunate followed by artemether–lumefantrine. However, parasite clearance was delayed, and despite a negative blood film following treatment, the patient ...
Jye Travis +6 more
wiley +1 more source
Heritability of the human infectious reservoir of malaria parasites. [PDF]
BackgroundStudies on human genetic factors associated with malaria have hitherto concentrated on their role in susceptibility to and protection from disease. In contrast, virtually no attention has been paid to the role of human genetics in eliciting the
Yaye Ramatoulaye Lawaly +24 more
doaj +1 more source
Background Artemisinin-based combinations differ in their impact on gametocyte prevalence and density. This study assessed female and male gametocyte dynamics after treating children with uncomplicated Plasmodium falciparum malaria with either ...
Johanna M. Roth +8 more
doaj +1 more source

