Results 211 to 220 of about 110,079 (354)

Neurocognitive, behavioral, and treatment burden as key predictors of parental stress in pediatric epilepsy

open access: yesEpilepsia, EarlyView.
Parental stress is linked to child cognitive impairment, internalizing symptoms, complex treatments, and lower caregiver education. No gender differences were found, though most caregivers were mothers. Findings suggest the need for support beyond seizure control.
Cinzia Correale   +11 more
wiley   +1 more source

Drug discovery and preclinical testing of drug candidates for developmental and epileptic encephalopathies

open access: yesEpilepsia, EarlyView.
Abstract Drug development for developmental and epileptic encephalopathies (DEEs) follows different strategies on one hand including disease‐targeting precision medicine approaches considering the genetic variants and pathomechanisms in DEEs and on the other hand including therapeutic approaches with novel targets or second‐generation drug candidates ...
Heidrun Potschka, Daniel Pérez‐Pérez
wiley   +1 more source

PAC‐FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures

open access: yesEpilepsia, EarlyView.
Abstract Objective Central to the development of novel antiseizure medications (ASMs) is testing of antiseizure activity in preclinical models. Although various well‐established models exist, their predictive validity across the spectrum of clinical epilepsies has been less clear.
Lyndsey L. Anderson   +9 more
wiley   +1 more source

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