Results 51 to 60 of about 131,516 (182)

Modulation of the GABAergic pathway for the treatment of fragile X syndrome. [PDF]

, 2014
Fragile X syndrome (FXS) is the most common genetic cause of intellectual disability and the most common single-gene cause of autism. It is caused by mutations on the fragile X mental retardation gene (FMR1) and lack of fragile X mental retardation ...
Hagerman, Randi J, Hare, Emma B, Lozano, Reymundo   +2 more
core   +1 more source

Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation. [PDF]

, 2012
Tetramethylenedisulfotetramine (TETS) is a potent convulsant that is considered a chemical threat agent. We characterized TETS as an activator of spontaneous Ca²⁺ oscillations and electrical burst discharges in mouse hippocampal neuronal cultures at 13 ...
Cao, Zhengyu, Hammock, Bruce D, Lein, Pamela J, McCoy, Mark, Pessah, Isaac N, Rogawski, Michael A   +5 more
core   +2 more sources

Extracellular expression of glutamate decarboxylase B in Escherichia coli to improve gamma-aminobutyric acid production

AMB Express, 2016
Escherichia coli overexpressing glutamate decarboxylase GadB can produce gamma-aminobutyric acid with addition of monosodium glutamate. The yield and productivity of gamma-aminobutyric acid might be significantly improved if the overexpressed GadB in E ...
Anqi Zhao, Xiaoqing Hu, Ye Li, Cheng Chen, Xiaoyuan Wang   +4 more
semanticscholar   +1 more source

Insights into GABA receptor signalling in TM3 Leydig cells [PDF]

, 2005
gamma-Aminobutyric acid (GABA) is an emerging signalling molecule in endocrine organs, since it is produced by endocrine cells and acts via GABA(A) receptors in a paracrine/autocrine fashion.
Artur Mayerhofer, Behar TN, Ben Ari Y, Berman JA, Christof Geigerseder, Erdo SL, Frungieri MB, Fukura H, Gilon P, Haydar TF, Karl Föhr, Kriegstein AR, Lars Kunz, Lauder JM, Lee W, Leinekugel X, Malherbe P, Maric D, Mayerhofer A, Mayerhofer A, Mayerhofer A, Monica B. Frungieri, Owens DF, Owens DF, Ricardo S. Calandra, Richard F.G. Doepner, Ritta MN, Romi Raemsch, Silvia I. Gonzalez-Calvar   +28 more
core   +2 more sources

Reduced gamma-aminobutyric acid concentration is associated with physical disability in progressive multiple sclerosis.

Brain : a journal of neurology, 2015
Neurodegeneration is thought to be the major cause of ongoing, irreversible disability in progressive stages of multiple sclerosis. Gamma-aminobutyric acid is the principle inhibitory neurotransmitter in the brain.
N. Cawley, B. Solanky, N. Muhlert, C. Tur, R. Edden, C. Wheeler-Kingshott, David H. Miller, A. Thompson, O. Ciccarelli   +8 more
semanticscholar   +1 more source

Optimization of Gamma Aminobutyric Acid Production from Various Protein Hydrolysates by Lactiplantibacillus plantarum MCM4

Applied Food Biotechnology, 2022
Background and Objective: Gamma aminobutyric acid (GABA) is a non-protein amino acid with various physiological properties that is used as synthetic drugs for curing anxiety, acute stress, and hypertension.
Ali Moayedi, Zahra Zareie, Forough Yaghoubi, Morteza Khomeiri   +3 more
doaj   +1 more source

Disrupted GABAergic facilitation of working memory performance in people with schizophrenia. [PDF]

, 2020
ObjectivesGamma-Amiobutyric acid (GABA) is a primary inhibitory neurotransmitter that facilitates neural oscillations that coordinate neural activity between brain networks to facilitate cognition.
Carter, CS, Hurtado, MY, Lesh, TA, Maddock, RJ, Niendam, TA, Ragland, JD, Ranganath, C, Tanase, C   +7 more
core  

Combined therapy with GABA and proinsulin/alum acts synergistically to restore long-term normoglycemia by modulating T-cell autoimmunity and promoting β-cell replication in newly diabetic NOD mice. [PDF]

, 2014
Antigen-based therapies (ABTs) fail to restore normoglycemia in newly diabetic NOD mice, perhaps because too few β-cells remain by the time that ABT-induced regulatory responses arise and spread.
Chen, Zheying, Dang, Hoa, Kaufman, Daniel L, Nguyen, An Viet, Tian, Jide   +4 more
core   +1 more source

The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABA_A receptor-mediated inhibition [PDF]

, 2014
Modulation of thalamocortical (TC) relay neuron function has been implicated in the sedative and hypnotic effects of general anaesthetics. Inhibition of TC neurons is mediated predominantly by a combination of phasic and tonic inhibition, together with a
Alkire, Andrada, Angel, Belelli, Belelli, Belelli, Bonin, Brickley, Chandra, Ching, Cope, Coulter, Farrant, Fiset, Franks, Franks, Gili, Glykys, Hales, Herd, Herd, Hill-Venning, Hofbauer, Huguenard, Iyer, Jensen, Jia, Jia, Jurd, Kasugai, Kralic, Kralic, Kralic, Kralic, Krosigk, McKernan, Mihalek, Olsen, Orser, Peden, Peng, Pistis, Purdon, Reynolds, Rudolph, Rudolph, Steriade, Steriade, Sur, Talavera, Thomson, Tretter, Uchida, Wafford, White, Yang, Ying, Ying   +57 more
core   +2 more sources

Realising the therapeutic potential of neuroactive steroid modulators of the GABA_A receptor [PDF]

, 2020
In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR).
Belelli, Delia, Gee, Kelvin W., Hogenkamp, Derk, Lambert, Jeremy J.   +3 more
core   +1 more source