Results 51 to 60 of about 110,079 (354)

Cooperative Rh2(OAc)4/Chiral Phosphoric Acid‐Catalyzed (3 + 3)‐Cycloadditions of Pyrrole‐3‐Methides and Carbonyl Ylides

Advanced Synthesis &Catalysis, EarlyView.
A stereoselective one‐step (3 + 3)‐cycloaddition between in situ generated pyrrole‐3‐methides and carbonyl ylides has been developed using cooperative rhodium and chiral phosphoric acid catalysis. The reaction affords oxa‐bridged cyclohepta[1,2‐b]pyrroles bearing three stereogenic centers, including two quaternary ones, in high yields and ...
Philipp Stehr, Christoph Schneider
wiley   +1 more source

Temporal coding at the immature depolarizing GABAergic synapse

Frontiers in Cellular Neuroscience, 2010
In the developing hippocampus, GABA exerts depolarizing and excitatory actions and contributes to the generation of neuronal network driven Giant Depolarizing Potentials (GDPs).
Guzel Valeeva, Guzel Valeeva, Azat Abdullin, Azat Abdullin, Azat Abdullin, Roman Tyzio, Andrei Skorinkin, Evgeny Nikolski, Yehezkiel Ben-Ari, Rustem Khazipov   +9 more
doaj   +1 more source

Lack of evidence for central sensitization in idiopathic, non-traumatic neck pain : a systematic review [PDF]

, 2015
Background: Chronic neck pain is a common problem with a poorly understood pathophysiology. Often no underlying structural pathology can be found and radiological imaging findings are more related to age than to a patient's symptoms.
Bramer, Wichor, Cagnie, Barbara, Danneels, Lieven, Dolphens, Mieke, Kregel, Jeroen, Kuipers, Mandy, Malfliet, Anneleen, Meeus, Mira, Nijs, Jo, Roussel, Nathalie   +9 more
core   +1 more source

Neutrophil Extracellular Trap Reprograms Cancer Metabolism to Form a Metastatic Niche Promoting Non‐Small Cell Lung Cancer Brain Metastasis

Advanced Science, EarlyView.
This study mainly combines spatial/single‐cell transcriptomics and metabolomics to reveal LOX+ Malig‐5 as NSCLC brain metastasis‐initiating cells, forming a niche with NET‐releasing neutrophils via the NET‐KRT10 axis. The metastatic niche is involved with metabolic reprogramming, with palmitic acid serving as a key metabolite.
Bo Chen, Karrie M. Kiang, Fangkun Liu, Chuntao Li, Xizhe Li, Chen Weiwei, Xin Fu, Gelei Xiao, Jingyi Sun, Erhan Da, Junbo Liao, Hongshu Zhou, Li Meng, Li Zhou, Tao Song, Longbo Zhang, Gilberto Ka‐Kit Leung, Liyang Zhang   +17 more
wiley   +1 more source

Synergistic effects of gamma-aminobutyric acid and melatonin on seed germination and cadmium tolerance in tomato [PDF]

, 2023
Yiying Lv, Yongteng Zhao, Yuansheng He, Jiming Wang, Yuanxian Zheng, Xiaolong Chen, Feiyan Huang, Jiani Liu, Lei Yu   +8 more
openalex   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

Neural Regeneration Research
Pain is often comorbid with emotional disorders such as anxiety and depression. Hyperexcitability of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric
Lu Guan, Mengting Qiu, Na Li, Zhengxiang Zhou, Ru Ye, Liyan Zhong, Yashuang Xu, Junhui Ren, Yi Liang, Xiaomei Shao, Jianqiao Fang, Junfan Fang, Junying Du   +12 more
doaj   +1 more source

Efficient gamma-aminobutyric acid bioconversion by engineered Escherichia coli

Biotechnology & Biotechnological Equipment, 2018
Gamma-aminobutyric acid (GABA) can be converted into 2-pyrrolidone, an intermediate in the synthesis of nylon 4 and agrochemicals, which has great potential for application in the chemical industry. The main aim of this work was to construct a simple and
Chongrong Ke, Jie Wei, Yang Ren, Xinwei Yang, Jia Chen, Jianzhong Huang   +5 more
doaj   +1 more source

Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. [PDF]

, 2020
Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the ...
Carrette, Lieselot LG, de Guglielmo, Giordano, George, Olivier, Kallupi, Marsida, Kononoff, Jenni, Palmer, Abraham A, Schweitzer, Paul, Solberg Woods, Leah C   +7 more
core  

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Advanced Science, EarlyView.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer   +10 more
wiley   +1 more source