Results 71 to 80 of about 94,242 (328)

In Situ Electrically Resettable Field‐Effect Transistor Biosensors for Continuous and Multiplexed Neurotransmitter Detection

Advanced Science, EarlyView.
The research team integrated a potentiometrically controlled pH electrode with carbon nanotube (CNT) field‐effect transistor (FET) biosensors on a single chip using compatible processes. By employing zonal modification and optimized pH‐sensitive probes, they achieved simultaneous quadruple‐target detection and tenfold reusability under physiological ...
Bo Xiao, Tingxian Li, Xianmao Cao, Yang Zhang, Jianping He, Mengmeng Xiao, Zhiyong Zhang   +6 more
wiley   +1 more source

Photocontrolled Release of Urea Enables the Detection of Urea–Urease Intermediates by Cryo‐FTIR

Angewandte Chemie, EarlyView.
Urease is a fast enzyme, presenting kcat of the order of 103–104 s−1. To enable the visualization of its mechanism we explored the technique of cryo‐FTIR. By means of using a ruthenium complex as a caged‐urea, upon light irradiation urea was released and we could see the coordination of the urea to the active site.
Caterina G.C. Marques Netto, Sarah Bell, Caio B. Castro, Pedro Henrique Machado, Vatsal Purohit, Katherine M. Davis, Ana Paula L. Batista, R. Brian Dyer   +7 more
wiley   +2 more sources

Brain GABA and Glutamate Concentrations Following Chronic Gabapentin Administration: A Convenience Sample Studied During Early Abstinence From Alcohol. [PDF]

, 2018
Gabapentin (GBP), a GABA analog that may also affect glutamate (Glu) production, can normalize GABA and Glu tone during early abstinence from alcohol, effectively treating withdrawal symptoms and facilitating recovery.
Durazzo, Timothy C, Meyerhoff, Dieter J, Murray, Donna E, Pennington, David L   +3 more
core   +2 more sources

Covalent Organic Frameworks‐Delivered Reuterin Drives Trained Immunity in Tumor‐Associated Macrophages to Enhance Melanoma Immunotherapy via Glycerophospholipid Metabolism

Advanced Science, EarlyView.
Covalent organic framework (COF)‐reuterin induces trained immunity in tumor‐associated macrophages, promoting the generation of nitric oxide and reactive oxygen species, thereby enhancing the antitumor immune response. Additionally, COF‐Reuterin directly kills tumor cells while simultaneously eradicating pathogenic intratumoural bacteria.
Jian‐Gang Zhang, Xiao‐Mei Zhang, Xi Wu, Cheng‐Kai Zhou, Zhen‐Zhen Liu, Xue‐Yue Luo, Liang Zhang, Wei Chen, Yong‐Jun Yang   +8 more
wiley   +1 more source

Cervical dystonia: a disorder of the midbrain network for covert attentional orienting.

Frontiers in Neurology, 2014
While the pathogenesis of cervical dystonia remains unknown, recent animal and clinical experimental studies have indicated its probable mechanisms. Abnormal temporal discrimination is a mediational endophenotype of cervical dystonia and informs new ...
Michael eHutchinson, Michael eHutchinson, Tadashi eIsa, Anna eMolloy, Anna eMolloy, Laura eWilliams, Laura eWilliams, Okka eKimmich, Okka eKimmich, Fiona eMolloy, Helena eMoore, Daniel G Healy, Tim eLynch, Cathal eWalsh, John eButler, Richard eReilly, Richard eWalsh, Sean eO'Riordan, Sean eO'Riordan   +18 more
doaj   +1 more source

GABA-modulating bacteria of the human gut microbiota. [PDF]

, 2019
The gut microbiota affects many important host functions, including the immune response and the nervous system1. However, while substantial progress has been made in growing diverse microorganisms of the microbiota2, 23-65% of species residing in the ...
Clardy, Jon, Dietrich, David, Dubin, Marc J, Gilbert, Jack A, Kim, Ki Hyun, Knight, Rob, Lekbua, Asama, Levering, Jennifer, Lewis, Kim, Liston, Conor, Liu, Joanne K, McDonald, Daniel, Mroue, Nader, Ramadhar, Timothy R, Sharma, Anukriti, Stewart, Eric J, Strandwitz, Philip, Terekhova, Darya, Zengler, Karsten   +18 more
core  

Cognitive outcome and gamma noise power unrelated to neuregulin 1 and 3 variation in schizophrenia [PDF]

, 2014
Background Neuregulins are a family of signalling proteins that orchestrate a broad range of cellular responses. Four genes encoding Neuregulins 1–4 have been identified so far in vertebrates. Among them, Neuregulin 1 and Neuregulin 3 have been reported
Cieza-Borrella, C, Díez, Á, González-Sarmiento, R, Molina, V, Papiol, S, Suazo, V   +5 more
core   +6 more sources

SCRIPT: Predicting Single‐Cell Long‐Range Cis‐Regulation Based on Pretrained Graph Attention Networks

Advanced Science, EarlyView.
SCRIPT is a novel method inferring single‐cell cis‐regulatory relationships (CRRs) from transcriptomic and chromatin accessibility data. SCRIPT incorporates two key innovations: graph causal attention networks supported by empirical CRR evidence, and representation learning enhanced through pretraining on atlas‐scale single‐cell data.
Yu Zhang, Baole Wen, Yifeng Jiao, Yuchen Liu, Xin Guo, Yushuai Wu, Jiyang Li, Limei Han, Yinghui Xu, Xin Gao, Yuan Qi, Yuan Cheng, Ying He, Weidong Tian   +13 more
wiley   +1 more source

Insilico Analysis of γ- Aminobutaric Acid Transaminase (GABA-T) of Brassica napus (Rape)

Journal of Advanced Biotechnology and Experimental Therapeutics, 2019
γ-Aminobutyric acid (GABA) is a very important metabolite which plays a crucial role in signal transmission, stress metabolism and some other activities are also reported. Although the actual role of GABA shunt is not clearly understood. Three key
Md. Shahjahan, Shahidur Rahman
doaj   +1 more source

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease. [PDF]

, 2019
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD), increasing risk and decreasing age of disease onset. Many studies have demonstrated the detrimental effects of apoE4 in varying cellular contexts.
Huang, Yadong, Jones, Emily A, Najm, Ramsey   +2 more
core   +1 more source