Results 71 to 80 of about 93,041 (352)

Combined therapy with GABA and proinsulin/alum acts synergistically to restore long-term normoglycemia by modulating T-cell autoimmunity and promoting β-cell replication in newly diabetic NOD mice. [PDF]

, 2014
Antigen-based therapies (ABTs) fail to restore normoglycemia in newly diabetic NOD mice, perhaps because too few β-cells remain by the time that ABT-induced regulatory responses arise and spread.
Chen, Zheying, Dang, Hoa, Kaufman, Daniel L, Nguyen, An Viet, Tian, Jide   +4 more
core   +1 more source

Chromosome‐Level Genome Assembly of the Leafcutter Bee Megachile rotundata Reveals Its Ecological Adaptation and Pollination Biology

Advanced Science, EarlyView.
The genome of Megachile rotundata, an extensively managed solitary pollination bee species, has been sequenced, covering 280.68 Mb and predicting 10 701 genes. The study reveals significant expansions of the Toll gene family and their abundant expression in diapause prepupae, highlighting enhanced immune responses during diapause. This genome serves as
Rangjun Shi, Pan Duan, Mengmeng Zhu, Rong Zhang, Zihua Zhao, Xin Nie, Hanhou He, Li Hou, Xianhui Wang   +8 more
wiley   +1 more source

New insights into glioma frequency maps: From genetic and transcriptomic correlate to survival prediction

International Journal of Cancer, Volume 152, Issue 5, Page 998-1012, 1 March 2023., 2023
What's new? The spatial distribution of glioma is nonrandom. However, whether pathological grade influences glioma distribution across the brain remains unclear. Here, the authors built a population‐based frequency map for 396 patients with glioblastoma multiforme and 190 patients with lower‐grade glioma, revealing their distinct topographic ...
Hongbo Bao, Peng Ren, Liye Yi, Zhonghua Lv, Wencai Ding, Chenlong Li, Siyang Li, Zhipeng Li, Xue Yang, Xia Liang, Peng Liang   +10 more
wiley   +1 more source

Carbon Doping of MgB2 by Toluene and Malic-Acid-in-Toluene [PDF]

, 2010
The decomposition of malic acid in the presence of Mg and B was studied using Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA) which revealed that malic acid reacted with Mg but not B. Also, the addition of toluene to dissolve malic acid followed by subsequent drying resulted in no reaction with Mg, indicating that the malic
arxiv   +1 more source

Large presence of carbonic acid in CO$_2$-rich aqueous fluids under Earth's mantle conditions [PDF]

Journal of Physical Chemistry Letters 10, 5135-5141 (2019), 2019
The chemistry of carbon in aqueous fluids at extreme pressure and temperature conditions is of great importance to Earth's deep carbon cycle, which substantially affects the carbon budget at Earth's surface and global climate change. At ambient conditions, the concentration of carbonic acid in water is negligible, so aqueous carbonic acid was simply ...
arxiv   +1 more source

Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
The gut microbiome is a potential target for treating cardiovascular disease. It is found that prophylactic administration of Flavonifractor plautii or its metabolite desaminotyrosine (DAT) exerts pleiotropic cardioprotective effects via promoting cardiomyocyte survival and attenuating cardiac inflammation against myocardial ischemia/reperfusion (I/R ...
Heng Du, Xu Liu, Jianghua Shen, Hailong Yuan, Hao Zhang, Gan Xi, Yujing Li, Yuhan Wang, Jiahe Zhang, Chaofan Yang, Pengfei Xu, Jiawan Wang, Fang Wang, Siqi Liu, Yanan Zhou, Qi Gu, Jingjing Lu, Tuo Wei, Zeyu Gao, Jingyi Zang, Jun Wang, Moshi Song   +21 more
wiley   +1 more source

Tranexamic acid at cesarean delivery: Drug‐error deaths

International Journal of Gynecology &Obstetrics, Volume 160, Issue 1, Page 49-52, January 2023., 2023
Abstract The use of tranexamic acid for postpartum hemorrhage has entered obstetrical practice globally with the evidence‐based expectation of saving lives. This improvement in the care of women with postpartum hemorrhage has come at a price. For the anesthetist, having tranexamic acid ampoules close at hand would seem an obvious strategy to facilitate
Neil F. Moran, David G. Bishop, Susan Fawcus, Edward Morris, Haleema Shakur‐Still, Adam J. Devall, Ioannis D. Gallos, Mariana Widmer, Olufemi T. Oladapo, Arri Coomarasamy, G. Justus Hofmeyr   +10 more
wiley   +1 more source

Efficient gamma-aminobutyric acid bioconversion by engineered Escherichia coli

Biotechnology & Biotechnological Equipment, 2018
Gamma-aminobutyric acid (GABA) can be converted into 2-pyrrolidone, an intermediate in the synthesis of nylon 4 and agrochemicals, which has great potential for application in the chemical industry. The main aim of this work was to construct a simple and
Chongrong Ke, Jie Wei, Yang Ren, Xinwei Yang, Jia Chen, Jianzhong Huang   +5 more
doaj   +1 more source

Synergy of piracetam and aminalon in the cerebroprotective effect of olatropyl.

Medičnì Perspektivi, 2018
Optimization of pharmacotherapy of neurological and psychosomatic diseases led to the creation of com­bined medicines containing two or more components with different mechanisms of action, differently affecting the pathogenesis and clinical ...
V. I. Mamchur, S. N. Dronov
doaj   +1 more source

Multiple functional neurosteroid binding sites on GABAA receptors [PDF]

, 2019
Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for psychiatric diseases.
Akk, Gustav, Bracamontes, John R, Budelier, Melissa M, Chen, Zi-Wei, Cheng, Wayland W. L., Covey, Douglas F, Evers, Alex S, Germann, Allison L, Kathiresan, Krishnan, Manion, Brad, Qian, Ming-Xing, Reichert, David E, Shin, Daniel J   +12 more
core   +3 more sources