Gamma-glutamyl hydrolase - Open Access .click

Results 171 to 180 of about 9,031 (203)

Some of the next articles are maybe not open access.

Methotrexate intracellular disposition in acute lymphoblastic leukemia: a mathematical model of gamma-glutamyl hydrolase activity.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2003
Methotrexate (MTX) is an antifolate that is widely used for the treatment of childhood acute lymphoblastic leukemia (ALL) and a number of other malignant and nonmalignant diseases. Within cells, MTX is metabolized to more active methotrexate polyglutamates (MTXPG), and these polyglutamates are subsequently cleaved in lysosomes by gamma-glutamyl ...
John Carl, Panetta +4 more
openaire +1 more source

Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.

FEMS microbiology letters, 2006
gamma-Glutamyl-gamma-aminobutyrate hydrolase (PuuD) was purified and the properties of the enzyme were characterized. The active center of PuuD was identified as Cys-114 by site-directed mutagenesis. The expression of PuuD was induced by putrescine and O2 (substrates of the Puu pathway), while the addition of succinate or NH4Cl (products of the Puu ...
Shin, Kurihara +3 more
openaire +1 more source

N-Me-pAB-Glu-gamma-Glu-gamma-Tyr(3-NO(2)): an internally quenched fluorogenic gamma-glutamyl hydrolase substrate.

Bioorganic & medicinal chemistry letters, 2002
A gamma-glutamyl tripeptide containing an internally quenched fluorophore has been synthesized and shown to be a substrate for recombinant rat gamma-glutamyl hydrolase. HPLC, LC-MS, and fluorescence spectra support the conclusion that selective hydrolysis occurs at the penultimate peptide bond.
J J, Pankuch, J K, Coward
openaire +1 more source

Novel Extremophilic Enzymes Specialized in γ-Glutamyl Hydrolase Activity