Results 31 to 40 of about 9,031 (203)

Prediction of Methotrexate toxicity in Algerian Rheumatoid Arthritis Patients: Implication of GGH rs11545078 polymorphism

Journal de la Faculté de Médecine d'Oran, 2022
Objectives - The aim of this study is to determine the impact of the gamma glutamyl hydrolase (GGH) c.452C>T (dbSNP Id: rs 11545078) polymorphism on the Methotrexate (MTX) adverse drug reactions (ADRs) and on MTX gastro intestinal toxicity (GIT) in ...
Wefa Boughrara, Ahmed Benzaoui, Meriem Aberkane, Fatima Zohra Moghtit, Samia DORGHAM, Abdellah Boudjema   +5 more
doaj  

Proteomic Changes in Human Sperm During Sequential in vitro Capacitation and Acrosome Reaction

Frontiers in Cell and Developmental Biology, 2019
The male gamete is not completely mature after ejaculation and requires further events in the female genital tract to acquire fertilizing ability, including the processes of capacitation and acrosome reaction.
Judit Castillo, Orleigh Adeleccia Bogle, Meritxell Jodar, Forough Torabi, David Delgado-Dueñas, Josep Maria Estanyol, Josep Lluís Ballescà, David Miller, Rafael Oliva, Rafael Oliva   +9 more
doaj   +1 more source

Poly-γ-glutamic acid: production, properties and applications [PDF]

, 2015
University of Wolverhampton ...
Adetoro Ogunleye, Aditya Bhat, Ben-Zur, Bhat, Bhunia, Bodnár, Bovarnick, Candela, Cao, Choi, Craig Williams, Cromwick, David Hill, Graciela, Hanby, Ho, Ho, Inbaraj, Ivanovics, Ivanovics, Iza Radecka, Kada, Li, Mabrouk, Makino, McLean, Mesnage, Rehm, Sakai, Shih, Shyu, Sung, Thorne, Thorne, Tomcsik, Tsutomu, Uotani, Victor U. Irorere, Weber, Xu, Yasuzawa, Yokoi, Zwartouw   +42 more
core   +1 more source

Folate polyglutamylation is required for rice seed development [PDF]

, 2010
In plants, polyglutamylated folate forms account for a significant proportion of the total folate pool. Polyglutamylated folate forms are produced by the enzyme folylpolyglutamate synthetase (FPGS).
A Wingler, AD Hanson, AD Hanson, Anahi Santoyo Castelazo, Anne Diévart, B Gambonnet, B Shane, BA Moffatt, BF Lin, BF Lin, CR Somerville, D Heineke, David A. Barrett, Delphine Mieulet, E Cossins, Emmanuel Guiderdoni, G Orsomando, GJ Basset, GJ Basset, GJ Basset, Gregory Tucker, H Bauwe, H Imeson, Helen Parker, I Hayashi, JR Suh, K Gallardo, KR Lowe, L Chen, L DeSouza, LC Garratt, Malcolm J. Bennett, ML Jones, Nadège Lanau, Nampeung Anukul, O Galivan, PA Counce, Payam Mehrshahi, R Díaz de la Garza, Riza Abilgos Ramos, S Jabrin, S Ravanel, S Ravanel, S Storozhenko, V Besson, X Sun, Y Wang   +46 more
core   +2 more sources

Is Pharmacogenetic Panel Testing Applicable to Low-Dose Methotrexate in Rheumatoid Arthritis? – A Case Report

Pharmacogenomics and Personalized Medicine, 2022
Chiara Jeiziner,1 Samuel S Allemann,1 Kurt E Hersberger,1 Henriette E Meyer zu Schwabedissen2 1Pharmaceutical Care Research Group, Department Pharmaceutical Sciences, University of Basel, Basel, Switzerland; 2Biopharmacy, Department Pharmaceutical ...
Jeiziner C, Allemann SS, Hersberger KE, Meyer zu Schwabedissen HE   +3 more
doaj  

Co-Catalytic Metallopeptidases as Pharmaceutical Targets [PDF]

, 2003
Understanding the reaction mechanism of co-catalytic metallopeptidases provides a starting point for the design and synthesis of new molecules that can be screened as potential pharmaceuticals. Many of the enzymes that contain co-catalytic metallo-active
Bzymek, Krzysztof P., Holz, Richard C., Swierczek, Sabina I.   +2 more
core   +2 more sources

Several Hfq-dependent alterations in physiology of Yersinia enterocolitica O:3 are mediated by derepression of the transcriptional regulator RovM [PDF]

, 2017
In bacteria, the RNA chaperone Hfq enables pairing of small regulatory RNAs with their target mRNAs and therefore is a key player of post-transcriptional regulation network. As a global regulator, Hfq is engaged in the adaptation to external environment,
Bengoechea, José A, Fernández-Carrasco, Helena, Leskinen, Katarzyna, Pajunen, Maria I, Skurnik, Mikael, Varjosalo, Markku   +5 more
core   +1 more source

A proteinaceous organic matrix regulates carbonate mineral production in the marine teleost intestine [PDF]

, 2016
Marine teleost fish produce CaCO(3) in their intestine as part of their osmoregulatory strategy. This precipitation is critical for rehydration and survival of the largest vertebrate group on earth, yet the molecular mechanisms that regulate this ...
Adrian Pelin, Christophe M. R. LeMoine, Kevin L. Schauer, M. Danielle McDonald, Martin Grosell, Nicolas Corradi, Wesley C. Warren   +6 more
core   +2 more sources

γ-Glutamyl Hydrolase:  Kinetic Characterization of Isopeptide Hydrolysis Using Fluorogenic Substrates [PDF]

Biochemistry, 2008
Gamma-glutamyl hydrolase, a cysteine peptidase, catalyzes the hydrolysis of poly-gamma-glutamate derivatives of folate cofactors and many antifolate drugs. We have used internally quenched fluorogenic derivatives of glutamyl-gamma-glutamate and (4,4-difluoro)glutamyl-gamma-glutamate to examine the effect of fluorine substitution adjacent to the ...
Jessica P, Alexander, Thomas J, Ryan, David P, Ballou, James K, Coward   +3 more
openaire   +2 more sources

Folates and antifolates in rheumatoid arthritis

Pteridines, 2013
Almost all current standard treatment of care for patients with chronic inflammatory diseases such as rheumatoid arthritis (RA) includes the folate antagonist methotrexate (MTX).
Jansen Gerrit, Weijers Karin, Blits Marjolein, van der Heijden Joost, Gent Yoony, Al Marjon, van der Laken Conny, Molthoff Carla, Verweij Cor, Voskuijl Alexandre, Lems Willem, Scheper Rik, Peters Godefridus, Ratnam Manohar, Aassaraf Yehuda, Dijkmans Ben   +15 more
doaj   +1 more source