Novel circulating protein biomarkers for thyroid cancer determined through data-independent acquisition mass spectrometry [PDF]
PeerJ, 2020 Background Distinguishing between different types of thyroid cancers (TC) remains challenging in clinical laboratories. As different tumor types require different clinical interventions, it is necessary to establish new methods for accurate diagnosis of ...
Dandan Li +4 more
doaj +2 more sources
IIUM Medical Journal Malaysia, 2017 Introduction: Extracapsular spread (ECS) is one of the most important prognostic factors in oral squamous cell carcinoma (OSCC). Gamma Glutamyl Hydrolase (GGH) is a lysosomal enzyme which is involved in folate homeostasis. It is overexpressed in several human malignancies but its role in OSCC has never been reported.
Nor Aszlitah Burhanudin +1 more
openalex +3 more sources
Leaf apoplastic proteome composition in UV-B treated Arabidopsis thaliana mutants impaired in extracellular glutathione degradation [PDF]
, 2016 In plants, environmental perturbations often result in oxidative reactions in the apoplastic space, which are counteracted for by enzymatic and non-enzymatic antioxidative systems, including ascorbate and glutathione. The occurrence of the latter and its
Arrigoni, Giorgio +2 more
core +1 more source
Asian Pacific Journal of Cancer Prevention, 2012 Methotrexate (MTX) is an important drug for the treatment of childhood acute lymphoblastic leukemia (ALL). However, related toxicity occurs in many organs which may cause interruption of treatment, morbidity, and mortality. Single nucleotide polymorphisms (SNPs) of dihydrofolate reductase (DHFR) and gamma glutamyl hydrolase (GGH) are known to alter ...
Napatrupron Koomdee +3 more
openalex +4 more sources
Proteome readjustments in the apoplastic space of Arabidopsis thaliana ggt1 mutant leaves exposed to UV-B radiation [PDF]
, 2015 Ultraviolet-B radiation acts as an environmental stimulus, but in high doses it has detrimental effects on plant metabolism. Plasma membranes represent a major target for ROS generated by this harmful radiation.
ARRIGONI, GIORGIO +8 more
core +2 more sources
The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy response and survival in cervical cancer [PDF]
, 2013 Uncorrected proofAims: Cervical cancer is the third most frequent cancer in women worldwide, mostly treated with cisplatin-based chemoradiotherapy. Since it is known that folate metabolism might interfere with cisplatin effectiveness, we intended to ...
Augusto Nogueira +29 more
core +5 more sources
Pharmacogenomics in children: advantages and challenges of next generation sequencing applications [PDF]
, 2013 Pharmacogenetics is considered as a prime example of how personalized medicine nowadays can be put into practice. However, genotyping to guide pharmacological treatment is relatively uncommon in the routine clinical practice. Several reasons can be found
De Paepe, Anne, Vanakker, Olivier
core +4 more sources
Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma. [PDF]
, 2017 Inter-individual differences in toxic symptoms and pharmacokinetics of high-dose methotrexate (MTX) treatment may be caused by genetic variants in the MTX pathway.
Bertino +33 more
core +1 more source
Proteomic analysis of soybean leaves in a compatible and an incompatible interaction with Phakopsora pachyrhizi. [PDF]
, 2017 Asian soybean rust (ASR), which is incited by the fungus Phakopsora pachyrhizi, is considered one of the most aggressive diseases to the soybean culture.
BARROS, E. G. de +5 more
core +1 more source
Association of warfarin dose with genes involved in its action and metabolism [PDF]
, 2007 We report an extensive study of variability in genes encoding proteins that are believed to be involved in the action and biotransformation of warfarin.
Mia Wadelius +73 more
core +1 more source