Results 11 to 20 of about 9,031 (203)

A central role for gamma-glutamyl hydrolases in plant folate homeostasis [PDF]

open access: bronzeThe Plant Journal, 2010
Tariq A. Akhtar   +6 more
exaly   +4 more sources

Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro. [PDF]

open access: greenProceedings of the National Academy of Sciences, 1996
A cDNA encoding human gamma-glutamyl hydrolase has been identified by searching an expressed sequence tag data base and using rat gamma-glutamyl hydrolase cDNA as the query sequence. The cDNA encodes a 318-amino acid protein of Mr 35,960. The deduced amino acid sequence of human gamma-glutamyl hydrolase shows 67% identity to that of rat gamma-glutamyl ...
Rong Yao   +3 more
exaly   +5 more sources

GGH (gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) [PDF]

open access: greenAtlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on GGH (gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase), with data on DNA, on the protein encoded, and where the gene is implicated.
Qing Cheng, Evans We
openalex   +4 more sources

Genetic Polymorphism of C452T (T127I) in Human .GAMMA.-Glutamyl Hydrolase in a Japanese Population

open access: bronzeBiological and Pharmaceutical Bulletin, 2007
We investigated the genotype distribution and allele frequency of C452T polymorphism of gamma-glutamyl hydrolase (GGH) gene, which causes the decreased enzymatic activity affecting the efficacy of methotrexate (MTX), in a Japanese population. The polymerase chain reaction-restriction fragment length polymorphism assay was applied to determine the ...
Hideki Hayashi   +4 more
openalex   +4 more sources

Gamma-glutamyl hydrolase gene polymorphisms – another way to predict methotrexate efficacy in rheumatoid arthritis

open access: diamondRussian Journal of Immunology, 2020
The current treatment strategy for rheumatoid arthritis has been formulated within the framework of the European League Against Rheumatism (EULAR) concept “Treatment to achieve the goal”. Methotrexate prescribed as soon as possible after verifying rheumatoid arthritis is recognized as a first-line drug that allows to achieve disease remission and ...
I. V. Devald   +4 more
openalex   +3 more sources

Gamma-glutamyl hydrolase conjugase). Purification and properties of the bovine hepatic enzyme.

open access: hybridJournal of Biological Chemistry, 1975
Bovine hepatic gamma-glutamyl hydrolase (conjugase) has been purified to homogeneity. A feature of the purification procedure was the use of high affinity macromolecular polyanion enzyme inhibitors which formed tight complexes with the enzyme altering its solubility, gel filtration, and ion exchange properties.
Martin Silink   +3 more
openalex   +3 more sources

Identification of genes involved in inbreeding depression of reproduction in Langshan chickens [PDF]

open access: yesAnimal Bioscience, 2021
Objective Inbreeding depression of reproduction is a major concern in the conservation of native chicken genetic resources. Here, based on the successful development of strongly inbred (Sinb) and weakly inbred (Winb) Langshan chickens, we aimed to ...
Qian Xue   +12 more
doaj   +1 more source

Evaluation of the influence of polymorphisms of the transporter genes (RFC1, MDR1) and GGH on the efficacy of methotrexate in rheumatoid arthritis

open access: yesСовременная ревматология, 2023
The efficacy of methotrexate (MT) in patients with rheumatoid arthritis (RA) may be determined by genetic factors.Objective: to evaluate the isolated and combined effects of single nucleotide polymorphisms (SNPs) of membrane transporter proteins (RFC1 ...
I. V. Devald   +7 more
doaj   +1 more source

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