Results 1 to 10 of about 9,031 (203)

Interaction between glycolysis‒cholesterol synthesis axis and tumor microenvironment reveal that gamma-glutamyl hydrolase suppresses glycolysis in colon cancer [PDF]

Frontiers in Immunology, 2022
BackgroundMetabolic reprogramming is a feature of cancer. However, colon cancer subtypes based on the glycolysis‒cholesterol synthesis axis have not been identified, and little is known about connections between metabolic features and the tumor ...
Yan-Jie Chen, Xi Guo, Xi Guo, Xi Guo, Meng-Ling Liu, Yi-Yi Yu, Yue-Hong Cui, Xi-Zhong Shen, Tian-Shu Liu, Tian-Shu Liu, Tian-Shu Liu, Li Liang, Li Liang, Li Liang   +13 more
doaj   +5 more sources

Elevated Expression of Gamma-Glutamyl Hydrolase Is Associated With Poor Prognosis and Altered Immune Signature in Uterine Corpus Endometrial Carcinoma [PDF]

Frontiers in Genetics, 2022
Uterine corpus endometrial carcinoma (UCEC) is a common malignant tumor of the female reproductive system with poor prognosis in advanced, recurrent, and metastatic cases.
Cong Yu, Haining Qi, Yanhui Zhang, Wen Zhao, Guoying Wu   +4 more
doaj   +6 more sources

Genetic variation in folylpolyglutamate synthase and gamma-glutamyl hydrolase and plasma homocysteine levels in the Singapore Chinese Health Study. [PDF]

Mol Genet Metab, 2012
The enzymes folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH) are essential for determining intracellular folate availability for one-carbon metabolism (OCM) pathways. FPGS adds glutamyl groups to the folate molecule, thereby converting folate into the preferred substrate for several enzymes in OCM pathways.
Oppeneer SJ, Ross JA, Koh WP, Yuan JM, Robien K.   +4 more
europepmc   +6 more sources

Interethnic differences in single and haplotype structures of folylpolyglutamate synthase and gamma-glutamyl hydrolase variants and their influence on disease susceptibility to acute lymphoblastic leukemia in the Indian population: An exploratory study [PDF]

Indian Journal of Medical and Paediatric Oncology, 2018
Aim: We aim to establish the genotype and haplotype frequencies of folylpolyglutamate synthase (FPGS rs10106 and rs1544105) and gamma-glutamyl hydrolase (GGH rs3758149 and rs11545078) variants in the South Indian population (SI) and to study the ...
Sunitha Kodidela, Suresh Chandra Pradhan, Biswajit Dubashi, Debdatta Basu   +3 more
doaj   +2 more sources

High gamma-glutamyl hydrolase and low folylpolyglutamate synthetase expression as prognostic biomarkers in patients with locally advanced gastric cancer who were administrated postoperative adjuvant chemotherapy with S-1. [PDF]

J Cancer Res Clin Oncol, 2020
Maezawa Y, Sakamaki K, Oue N, Kimura Y, Hashimoto I, Hara K, Kano K, Aoyama T, Hiroshima Y, Yamada T, Yamamoto N, Ogata T, Ito H, Cho H, Shiozawa M, Yoshikawa T, Morinaga S, Rino Y, Yasui W, Masuda M, Miyagi Y, Oshima T.   +21 more
europepmc   +3 more sources

The GGH/HuR Complex Binds and Stabilizes mRNAs to Maintain Tumor Cell Cycle and DNA Replication

Advanced Science
GGH (Gamma‐glutamyl hydrolase) is a folate metabolism enzyme that hydrolyzes intracellular polyglutamylated folates and is highly expressed in various cancers. It remains unclear whether GGH functions as an oncogene and its underlying mechanisms in tumor
Yu Li, Xinrui Li, Yuhui Du, Sijie Chen, Xiaoniu He, Zhangrong Xie, Zhiqing Zhou, Huijie Zhao, Xiaofei Zeng, Guoan Chen   +9 more
doaj   +2 more sources

Crystal structure of plant γ-glutamyl peptidase 1: implications for sulfur metabolism and secondary metabolite biosynthesis. [PDF]

FEBS J
The crystal structures of Arabidopsis thaliana γ‐glutamyl peptidase 1 (GGP1), including the covalent intermediate state, were determined. GGP1 is involved in both glutathione degradation in the primary metabolism and glutathione conjugate processing in the secondary metabolism of glucosinolate and camalexin biosynthesis.
Sone K, Ito T, Sawada H, Yamada C, Kashima T, Miyanaga A, Ohkama-Ohtsu N, Fushinobu S.   +7 more
europepmc   +2 more sources

Gene expression levels of gamma-glutamyl hydrolase in tumor tissues may be a useful biomarker for the proper use of S-1 and tegafur-uracil/leucovorin in preoperative chemoradiotherapy for patients with rectal cancer. [PDF]

Cancer Chemother Pharmacol, 2017
Sadahiro S, Suzuki T, Tanaka A, Okada K, Saito G, Miyakita H, Ogimi T, Nagase H.   +7 more
europepmc   +3 more sources

Serum protein gamma-glutamyl hydrolase, Ig gamma-3 chain C region, and haptoglobin are associated with the syndromes of pulmonary tuberculosis in traditional Chinese medicine. [PDF]

BMC Complement Altern Med, 2015
Jiang TT, Wang C, Wei LL, Yu XM, Shi LY, Xu DD, Chen ZL, Ping ZP, Li JC.   +8 more
europepmc   +3 more sources

Transsulfuration pathway thiols and methylated arginines: the hunter community study [PDF]

, 2013
Background: Serum homocysteine, when studied singly, has been reported to be positively associated both with the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine [ADMA, via inhibition of dimethylarginine dimethylaminohydrolase ...
Attia, John R., Carru, Ciriaco, Mangoni, Arduino A., McEvoy, Mark, Zinellu, Angelo   +4 more
core   +15 more sources