Results 101 to 110 of about 12,504 (230)

تغییرات فاکتورهای التهابی سرم پس از تجویز مهار کننده‌ی گاما سکرتاز در موش

مجله دانشکده پزشکی اصفهان, 2013
مقدمه: Notch signaling در بسیاری از فرایندهای رشد و نمو فیزیولوژیک و پاتولوژیک نقش دارد؛ مهارکننده‌های گاما سکرتاز می‌توانند سبب مهار Signaling آن گردند.
Majid Khazaei, Hajar Saeidi, Niloofar Shabanikia, Elmira Kalantari, Zoya Tahergorabi   +4 more
doaj  

Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite

, 2020
Yunhui Zhang, Kenneth M. Boy, Yong‐Jin Wu, Antonio Ramı́rez, Jeremy H. Toyn, Michael K. Ahlijanian, Charles F. Albright, Xiaoliang Zhuo, Benjamin M. Johnson, Rex Denton, Richard E. Olson, Lorin A. Thompson, John E. Macor   +12 more
openalex   +1 more source

APP‐mediated intracellular signaling rescues sleep impairment and blood–brain barrier leakage in Alzheimer's disease mouse model

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Amyloid beta peptide (Aβ) accumulation in the brain is an Alzheimer´s disease (AD) hallmark. Sleep disturbances hamper Aβ production and clearance, thereby exacerbating the Aβ burden. The mechanisms involved remain unclear. We reported that amyloid precursor protein (APP), the Aβ source, possesses intracellular signaling that ...
Clémentine Puech, Anjana Sadanand, Neil Coleman, Marilyn Ikhane, Mohammad Badran, Rong Wang, David Gozal, Angèle T. Parent   +7 more
wiley   +1 more source

Regulation of autophagy‐mediated pathways by diet, physical activity, and sleep in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease (AD) is a progressive, age‐related, neurodegenerative disorder marked by cognitive decline, memory loss, and accumulation of amyloid beta (Aβ) plaques and tau tangles. A key feature of AD is impaired protein homeostasis, often driven by autophagy dysfunction.
Ajish Ariyath, Zoe Mputhia, Christopher Dougherty, Bushra Kaleelur Rahuman, W. M. A. D. Binosha Fernando, Belinda Brown, Samantha L. Gardener, Stephanie R. Rainey‐Smith, Ralph Martins, Prashant Bharadwaj   +9 more
wiley   +1 more source

Additional file 2 of PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia

, 2021
Inge Govaerts, Cristina Prieto, Charlien Vandersmissen, Olga Gielen, Kris Jacobs, Sarah Provost, David Nittner, Johan Maertens, Nancy Boeckx, Kim De Keersmaecker, Heidi Segers, Jan Cools   +11 more
openalex   +1 more source

The Molecular Mechanism and Therapeutic Progress in Glomus Tumor

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Glomus tumor (GT) is a rare mesenchymal neoplasm presumed to originate from the neuromyoarterial glomus body. Its pathogenesis is complex and involves alterations in multiple genes and signaling pathways. In the era of precision medicine, increased molecular research has begun to elucidate the oncogenic drivers of GT, offering novel
Zhi Cheng Jiang, Zu Jue Cheng, Jue Xian Xiao, You Quan Huang, Zheng Ke, Jing Hui Xu, Xiang Kun Fu, Hui Huang   +7 more
wiley   +1 more source

Gamma-secretase subunits associate in intracellular membrane compartments in Arabidopsis thaliana [PDF]

, 2014
Michalina Smolarkiewicz, Tomasz Skrzypczak, Michał Michalak, Krzysztof Leśniewicz, J. Ross Walker, Gwyneth Ingram, Przemysław Wojtaszek   +6 more
openalex   +1 more source

Hidradenitis suppurativa: haploinsufficiency of gamma-secretase components does not affect gamma-secretase enzyme activityin vitro [PDF]

British Journal of Dermatology, 2016
Pink, A. E., Dafou, D., Desai, N., Holmes, O., Hobbs, C., Smith, C.h., Mortimer, P., Simpson, M. A, Trembath, R. C, Barker, J. N.   +9 more
openaire   +6 more sources

Mutations Alter Conformations and Dynamics of APP‐TMDs: An RDC Analysis

ChemistryEurope, Volume 4, Issue 2, February 2026.
How γ‐secretase selects its substrates has been an enigma because of the lack of a consensus sequence. Using residual dipolar couplings, we analyzed the conformations of one substrate and two mutants. Using snapshots of a molecular dynamics trajectory, we analyzed how well structures matched the measured RDC values.
Franziska Krause, Celine Moser, David Elsing, Mara Silber, Fabian Hoffmann, Yannik Woordes, Burkhard Luy, Claudia Muhle‐Goll   +7 more
wiley   +1 more source

Plastic associated endocrine disruptors reduce Nicastrin protein and potentiate inflammation in hidradenitis suppurativa skin disease

Nature Communications
Hidradenitis Suppurativa (HS) is an inflammatory skin disorder with limited treatments and unclear etiology. While monogenic HS is linked to gamma secretase mutations, particularly in the NCSTN subunit, the pathogenesis of the more common sporadic form ...
Kaitlin L. Williams, Beita Badiei, James Reilly, William Andrews, Hana B. Minsky, Nina Rossa Haddad, Eddie G. Martinez Pena, Mengqi Sun, Sam Lee, Ang Li, Leigh Curvin-Aquilla, Arieana Y. Johnson, Aiden Willis, Charles S. Kirby, Amy van Ee, Yingchao Xue, Carrie A. Cox, Shanmuga Priya Rajagopalan, Sewon Kang, Kurunthachalam Kannan, Julie Caffrey, Nathan K. Archer, Maureen Kane, Luis A. Garza   +23 more
doaj   +1 more source