Results 121 to 130 of about 11,895 (194)

Gamma-Secretase Inhibitor RO4929097 [PDF]

, 2020
openaire   +1 more source

Repurposing nirogacestat, a gamma secretase enzyme inhibitor in desmoid tumors. [PDF]

Future Oncol
Tansir G, Rastogi S, Gounder MM.
europepmc   +1 more source

Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia.

Am J Physiol Lung Cell Mol Physiol, 2023
Gwin MS, Alexeyev MF, Geurts AM, Lee JY, Zhou C, Yang XM, Cohen MV, Downey JM, Barrington RA, Spadafora D, Audia JP, Frank DW, Voth S, Pastukh VV, Bell J, Ayers L, Tambe DT, Nelson AR, Balczon R, Lin MT, Stevens T.   +20 more
europepmc   +1 more source

A Phase Ib/II Randomized Study of RO4929097, a Gamma-Secretase or Notch Inhibitor with or without Vismodegib, a Hedgehog Inhibitor, in Advanced Sarcoma. [PDF]

Clin Cancer Res, 2022
Gounder MM, Rosenbaum E, Wu N, Dickson MA, Sheikh TN, D'Angelo SP, Chi P, Keohan ML, Erinjeri JP, Antonescu CR, Agaram N, Hameed MR, Martindale M, Lefkowitz RA, Crago AM, Singer S, Tap WD, Takebe N, Qin LX, Schwartz GK.   +19 more
europepmc   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling. [PDF]

Cell Death Dis, 2022
Ferrarotto R, Mishra V, Herz E, Yaacov A, Solomon O, Rauch R, Mondshine A, Motin M, Leibovich-Rivkin T, Davis M, Kaye J, Weber CR, Shen L, Pearson AT, Rosenberg AJ, Chen X, Singh A, Aster JC, Agrawal N, Izumchenko E.   +19 more
europepmc   +1 more source

Studies on gamma-secretase activity and products

, 2010
gamma-Secretase is a transmembrane aspartyl protease involved in processing of a multitude of functionally diverse substrates within their transmembrane domains. gamma-Secretase cleavage of the amyloid precursor protein (APP) generates the APP intracellular domain (AICD) and the amyloid beta-peptide (Abeta). Abeta is a key player in the pathogenesis of
openaire   +1 more source

Gamma secretase inhibitors, DAPT and MK0752, exhibit synergistic anticancer effects with cisplatin and docetaxel in 2D and 3D models of breast cancer. [PDF]

Turk J Biol
Telli K, Gubat J, D'Arcy P, Yalçin Özuysal Ö.   +3 more
europepmc   +1 more source

Effects of a gamma-secretase inhibitor of notch signalling on transforming growth factor β1-induced urethral fibrosis. [PDF]

J Cell Mol Med, 2021
Huang S, Fu D, Wan Z, Li M, Li H, Chong T.   +5 more
europepmc   +1 more source

Presenilin/gamma-secretase regulates neurexin processing at synapses

, 2011
This work was supported by grants from the Junta de Andalucía, Consejería de Innovación, Ciencia y Empresa to FGS (Proyecto de Excelencia P07-CVI-02943) and Ministerio de Ciencia e Innovación of Spain to CAS (SAF2010-20925 and CIBERNED CB06/05/0042).
Gómez Scholl, Francisco Manuel, Servián Morilla, Emilia, Saura, Carlos A.   +2 more
openaire   +2 more sources