Results 131 to 140 of about 12,504 (230)

S1‐02–05: Gamma‐secretase modulators, nonsteroidal anti‐inflammatory drugs, and Alzheimer's disease: A review and update [PDF]

, 2008
Edward H. Koo
openalex   +1 more source

Nitrate Enhances Gastric Mucosa Defense and Repair Process in Ethanol‐Induced Gastric Ulcer Rats via the Notch–Tff2 Pathway

MedComm, Volume 7, Issue 2, February 2026.
Nitrate protects the three major barriers of the gastric mucosa, alleviating bleeding and inflammation of ethanol‐induced gastric ulcer in rats, and promotes migration of gastric epithelial cells, accelerating the restoration of the ulcerated epithelium, which is strongly related to TFF2, a gastric mucosal protective factor negatively regulated by the ...
Ying Liu, Xin Wen, Yuxuan Lin, Chunmei Zhang, Jinsong Wang, Guangyong Sun, Dong Zhang, Renhong Yan, Mo Chen, Songlin Wang, Shaorong Li   +10 more
wiley   +1 more source

The Potential of Gamma Secretase as a Therapeutic Target for Cardiac Diseases. [PDF]

J Pers Med, 2021
Sen S, Hallee L, Lam CK.
europepmc   +1 more source

Noninvasive imaging of amyloid‐beta and tau in rodent and nonhuman primate models

VIEW, Volume 7, Issue 1, February 2026.
Imaging of amyloid‐beta plaque and tau accumulation in rodent and nonhuman primate model of Alzheimer's disease. Created in BioRender. Ni R. 2026. https://BioRender.com/a97h5ec Abstract Neurodegenerative diseases are characterized by the aberrant accumulation of protein aggregates.
Ruiqing Ni, Axel Rominger
wiley   +1 more source

In vitro effects of gamma-secretase inhibition in HPV-positive and HPV-negative head and neck squamous cell carcinoma. [PDF]

Invest New Drugs, 2023
Varatanovic S, Maier T, Al-Gboore S, Stoiber S, Kandathil SA, Quint C, Brennus C, Heiduschka G, Kadletz-Wanke L, Brkic FF.   +9 more
europepmc   +1 more source

Synaptic Vesicle Glycoprotein 2A Suppresses Amyloidogenesis Beyond Its Synaptic Role: A Novel Mechanism Disrupting BACE1 Binding and Altering APP Localization

Aging Cell, Volume 25, Issue 2, February 2026.
Synaptic vesicle glycoprotein 2A, the newly identified APP‐binding protein, reduces amyloid‐β plaque deposition in Alzheimer's disease by suppressing the amyloidogenic pathway through inhibition of BACE1‐APP interaction and alteration of APP endosomal‐lysosomal localization.
Xiaoling Wang, Qian Zhang, Xiaomin Zhang, Jing Liu, Jingjing Zhang, Congcong Liu, Yuting Cui, Qiao Song, Yuli Hou, Yaqi Wang, Min Cao, Peichang Wang   +11 more
wiley   +1 more source

Interpreting the spectrum of gamma-secretase complex missense variation in the context of hidradenitis suppurativa-An in-silico study. [PDF]

Front Genet, 2022
Mintoff D, Pace NP, Borg I.
europepmc   +1 more source

Construction of Drug Screening Cell Model and Application to New Compounds Interfering Production and Accumulation of Beta-Amyloid by Inhibiting Gamma-Secretase

, 2011
Xilin Wang, Jie Yang, Ping-Yue Xu, Jie Chen, Dan Zhang, Yan Sun, Zhi-Ming Huang   +6 more
openalex   +2 more sources

Targeted Nanodelivery of WGX50 and Curcumin via Gold Nanoparticles for Alzheimer's Therapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder, posing a global health challenge. It affects millions of people, causing cognitive decline and a heavy burden on healthcare systems. Neuroinflammation is a key pathological feature of AD, often associated with the dysregulation of microRNAs such as hsa‐miR‐146a‐5p. WGX50 (N‐[
Madeeha Shahzad Lodhi, Muhammad Maisam, Muhammad Tahir Khan, Amina Bibi, Dongqing Wei, Kejie Mou   +5 more
wiley   +1 more source

Gamma Secretase Inhibitors as Potential Therapeutic Targets for Notch Signaling in Uterine Leiomyosarcoma. [PDF]

Int J Mol Sci, 2022
Abedin Y, Gabrilovich S, Alpert E, Rego E, Begum S, Zhao Q, Heller D, Einstein MH, Douglas NC.   +8 more
europepmc   +1 more source