Results 181 to 190 of about 12,504 (230)

Identification of PS1/gamma-secretase and glutamate transporter GLT-1 interaction sites. [PDF]

J Biol Chem
Perrin F, Sinha P, Mitchell SPC, Sadek M, Maesako M, Berezovska O.   +5 more
europepmc   +1 more source

P1‐168: Substrate requirements and mechanisms of intramembrane proteolysis by gamma‐secretase and related proteases [PDF]

, 2009
Christian Haass, Lucas Martin, Akio Fukumori, Harald Steiner, Regina Fluhrer   +4 more
openalex   +1 more source

Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators. [PDF]

Bioorg Med Chem, 2020
Rynearson KD, Buckle RN, Herr RJ, Mayhew NJ, Chen X, Paquette WD, Sakwa SA, Yang J, Barnes KD, Nguyen P, Mobley WC, Johnson G, Lin JH, Tanzi RE, Wagner SL.   +14 more
europepmc   +1 more source

Gamma-Secretase Inhibitor IX (GSI) Impairs Concomitant Activation of Notch and Wnt-Beta-Catenin Pathways in CD44+ Gastric Cancer Stem Cells [PDF]

, 2017
Samarpita Barat, Xi Chen, Khắc Cường Bùi, Przemyslaw Bozko, Julian Götze, Matthias Christgen, Till Krech, Nisar P. Malek, Ruben R. Plentz   +8 more
openalex   +1 more source

Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer’s Disease

, 2017
Matthew G. Bursavich, Bryce A. Harrison, Raksha Acharya, Donald E. Costa, Emily A. Freeman, Hilliary Hodgdon, Lori Hrdlicka, Hong Jin, Sudarshan Kapadnis, Jeffrey S. Moffit, Deirdre Murphy, Scott Nolan, Holger Patzke, Cuyue Tang, Melody Wen, Gerhard Koenig, Jean‐François Blain, Duane A. Burnett   +17 more
openalex   +1 more source

A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss. [PDF]

Nat Commun
Schilder AGM, Wolpert S, Saeed S, Middelink LM, Edge ASB, Blackshaw H, REGAIN Consortium, Pastiadis K, Bibas AG.   +8 more
europepmc   +1 more source

Identification of a Pan-Gamma-Secretase Inhibitor Response Signature for Notch-Driven Cholangiocarcinoma. [PDF]

Hepatology, 2020
O'Rourke CJ, Matter MS, Nepal C, Caetano-Oliveira R, Ton PT, Factor VM, Andersen JB.   +6 more
europepmc   +1 more source

Alpha-, Beta-, and Gamma-Secretase, Amyloid Precursor Protein, and Tau Protein Genes in the Hippocampal CA3 Subfield in an Ischemic Model of Alzheimer's Disease with Survival up to 2 Years. [PDF]

J Alzheimers Dis
Czuczwar SJ, Kocki J, Miziak B, Bogucki J, Bogucka-Kocka A, Pluta R.   +5 more
europepmc   +1 more source

Alzheimer's disease treatment by inhibition/modulation of the .GAMMA.-secretase activity

, 2009
Taisuke Tomita
openalex   +2 more sources