Results 11 to 20 of about 12,504 (230)
Neurobiology of Disease, 2017 Neurogenesis impairment is considered a major determinant of the intellectual disability that characterizes Down syndrome (DS), a genetic condition caused by triplication of chromosome 21. Previous evidence obtained in the Ts65Dn mouse model of DS showed
Fiorenza Stagni +10 more
doaj +2 more sources
Anilinotriazoles as potent gamma secretase modulators
Bioorganic & Medicinal Chemistry Letters, 2014 The design and synthesis of a novel series of potent gamma secretase modulators is described. Exploration of various spacer groups between the triazole ring and the aromatic appendix in 2 has led to anilinotriazole 28, which combined high in vitro and in vivo potency with an acceptable drug-like profile.
Adriana I. Velter +19 more
openalex +3 more sources
gamma‐secretase modulation: from bench to clinic [PDF]
Alzheimers DementAbstractCerebral beta‐amyloid accumulation is the key initiator of Alzheimer’s disease (AD) pathology. Most familial early‐onset AD mutations in the APP, PSEN1/2 genes increase the ratio of Abeta42:Abeta40, which drives beta‐amyloid accumulation in the brain.
Rynearson K.
europepmc +3 more sources
Notch signaling without the APH-2/nicastrin subunit of gamma secretase in Caenorhabditis elegans germline stem cells. [PDF]
GeneticsBrinkley DM +9 more
europepmc +3 more sources
Targeting γ-secretase in breast cancer
Breast Cancer: Targets and Therapy, 2012 Jianxun Han,1 Qiang Shen21Department of Chemical Engineering and Applied Chemistry, University of Toronto, 2Campbell Family Institute for Breast Cancer Research, Princess Margaret Hospital, University Health Network, Toronto, Ontario, CanadaAbstract ...
Han J, Shen Q
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Presenilin-Dependent Gamma-Secretase Activity Modulates Neurite Outgrowth
Neurobiology of Disease, 2002 Demonstration that cleavage of both APP and Notch are dependent on the product of the early onset Alzheimer's disease gene, presenilin-1 (PS1), has raised the possibility that Notch function may be altered in AD. This finding also suggests that Notch may
David J. Figueroa +6 more
doaj +3 more sources
Synaptic and endosomal localization of active gamma-secretase in rat brain. [PDF]
PLoS ONE, 2010 A key player in the development of Alzheimer's disease (AD) is the gamma-secretase complex consisting of at least four components: presenilin, nicastrin, Aph-1 and Pen-2.
Susanne Frykman +7 more
doaj +1 more source
Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease. [PDF]
PLoS ONE, 2009 Alzheimer disease (AD) is an age-related disorder. Aging and female gender are two important risk factors associated with sporadic AD. However, the mechanism by which aging and gender contribute to the pathogenesis of sporadic AD is unclear.
Lisa Placanica, Lei Zhu, Yue-Ming Li
doaj +1 more source
Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements. [PDF]
PLoS Biology, 2008 The presenilin/gamma-secretase complex, an unusual intramembrane aspartyl protease, plays an essential role in cellular signaling and membrane protein turnover.
Matthew L Hemming +3 more
doaj +1 more source