gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes. [PDF]
PLoS ONE, 2010 BACKGROUND: gamma-Secretase is an intramembrane aspartyl protease whose cleavage of the amyloid precursor protein (APP) generates the amyloid beta-peptide (Abeta) and the APP intracellular domain.
Jenny Frånberg +4 more
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Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio. [PDF]
PLoS ONE, 2009 Presenilin 1(PS1) is the catalytic subunit of gamma-secretase, the enzyme responsible for the Abeta C-terminal cleavage site, which results in the production of Abeta peptides of various lengths.
Kengo Uemura +9 more
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Male-specific association between a gamma-secretase polymorphism and premature coronary atherosclerosis. [PDF]
PLoS ONE, 2008 BACKGROUND: Atherosclerosis is a common multifactorial disease resulting from an interaction between susceptibility genes and environmental factors. The causative genes that contribute to atherosclerosis are elusive.
Karen M J van Loo +6 more
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Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila. [PDF]
PLoS ONE, 2008 The Amyloid Precursor Protein (APP) undergoes sequential proteolytic cleavages through the action of beta- and gamma-secretase, which result in the generation of toxic beta-amyloid (Abeta) peptides and a C-terminal fragment consisting of the ...
Garrett G Gross +5 more
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Gamma Secretase Modulators [PDF]
ACS Medicinal Chemistry Letters, 2013 Notes The authors declare no competing financial interest. Title: Gamma Secretase Modulators Application Number: WO 2013066740A1 Publication date: 10 May 2013 Priority Application: 61/553,384 Priority date: 31 October 2011 Inventors: W. Greenlee, D. Pissarnitski, Z. Zhao, Z.
openaire +2 more sources
Complex Regulation of gamma-Secretase: from Obligatory to Modulatory Subunits
Frontiers in Aging Neuroscience, 2015 gamma-Secretase is a four subunit, 19-pass transmembrane enzyme that cleaves amyloid precursor protein, catalyzing the formation of amyloid beta peptides that form amyloid plaques, which contribute to Alzheimer’s disease pathogenesis.
Natalya eGertsik +2 more
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Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells. [PDF]
PLoS ONE, 2010 BACKGROUND: The familial and sporadic forms of Alzheimer's disease (AD) have an identical pathology with a severe disparity in the time of onset [1]. The pathological similarity suggests that epigenetic processes may phenocopy the Familial Alzheimer's ...
Jesse C Wiley +6 more
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Neurobiology of Disease, 2005 In Alzheimer's disease, the complex catabolism of amyloid precursor protein (APP) leads to the production of amyloid-beta (Abeta) peptide, the major component of amyloid deposits.
Valérie Vingtdeux +12 more
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Gene expression profiling in cells with enhanced gamma-secretase activity.
PLoS ONE, 2009 BackgroundProcessing by gamma-secretase of many type-I membrane protein substrates triggers signaling cascades by releasing intracellular domains (ICDs) that, following nuclear translocation, modulate the transcription of different genes regulating a ...
Alexandra I Magold +2 more
doaj +1 more source
Propylthiouracil Attenuates Experimental Pulmonary Hypertension via Suppression of Pen-2, a Key Component of Gamma-Secretase. [PDF]
PLoS ONE, 2015 Gamma-secretase-mediated Notch3 signaling is involved in smooth muscle cell (SMC) hyper-activity and proliferation leading to pulmonary arterial hypertension (PAH).
Ying-Ju Lai +5 more
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