Gamma Delta T-Cell Based Cancer Immunotherapy: Past-Present-Future [PDF]
Frontiers in Immunology, 2022 γδ T-cells directly recognize and kill transformed cells independently of HLA-antigen presentation, which makes them a highly promising effector cell compartment for cancer immunotherapy.
José Saura-Esteller +9 more
doaj +2 more sources
Cutaneous gamma/delta T‐cell lymphoma [PDF]
JDDG - Journal of the German Society of Dermatology, 2009 SummaryOnly 40 cases of primary cutaneous gamma/delta T‐cell lymphoma (GD‐TCL) have been described. GD‐TCL was included as a provisional entity in the WHO‐EORTC classification of cutaneous lymphomas in 2005.GD‐TCL often failed to respond to polychemotherapy and radiation therapy and have a poor prognosis with a mean survival of only 15 months.
Elaine S Jaffe
exaly +4 more sources
Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local
Frontiers in Immunology, 2018 Human gamma delta T cells have extraordinary properties including the capacity for tumor cell killing. The major gamma delta T cell subset in human beings is designated Vγ9Vδ2 and is activated by intermediates of isoprenoid biosynthesis or ...
C. David Pauza +6 more
doaj +3 more sources
Clinical, Diagnostic and Prognostic Characteristics of Primary Cutaneous Gamma Delta T-cell Lymphomas [PDF]
Clinical Hematology International, 2022 Primary cutaneous γδ T-cell lymphoma (PCGDTL) is a rare subtype of non-Hodgkin lymphoma (NHL) that arises from T-cells with γδ T-cell receptors. The exact incidence of PCGDTL is unknown, as it is usually lumped with other cutaneous lymphomas, which are ...
Ibrahim N. Muhsen +5 more
doaj +2 more sources
Gamma delta T-cell reconstitution after allogeneic HCT: A platform for cell therapy [PDF]
Frontiers in Immunology, 2022 Allogeneic Hematopoietic stem cell transplantation (allo-HCT) is a curative platform for several hematological diseases. Despite its therapeutic benefits, the profound immunodeficiency associated with the transplant procedure remains a major challenge ...
Ahmed Gaballa +4 more
doaj +2 more sources
Primary Cutaneous Gamma-Delta T Cell Lymphomas: A Case Series and Overview of the Literature [PDF]
Dermatopathology, 2021 Primary cutaneous gamma-delta T cell lymphomas (PCGDTCLs) are rare and aggressive cutaneous malignancies that have been diagnostically challenging for dermopathologists and clinicians since their first published descriptions in 1991.
Silvia Alberti-Violetti +4 more
doaj +2 more sources
A Previously Unrecognized Granulomatous Variant of Gamma-Delta T-Cell Lymphoma [PDF]
Dermatopathology, 2021 Primary cutaneous γδ T-cell lymphoma (PCGD-TCL) is an extremely rare and aggressive T-cell neoplasm with complex heterogeneity. We present a series of two patients who presented with firm, subcutaneous nodules and were diagnosed with PCGD-TCL.
Tatsiana Pukhalskaya +3 more
doaj +2 more sources
Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas [PDF]
Nature Communications, 2020 Cutaneous gamma-delta T cell lymphomas are rare but aggressive cancers. Here, by DNA, RNA and T cell receptor sequencing, the authors elucidate the molecular ontogeny by revising the cell of origin and identifying potentially targetable mutations.
Jay Daniels +23 more
doaj +2 more sources
Isolated bone marrow gamma-delta T-Cell lymphoma: Another challenge to the WHO lymphoid neoplasm classification [PDF]
Leukemia Research Reports, 2023 Rohit Singh +5 more
doaj +2 more sources
Cerebrospinal fluid infiltration of primary cutaneous gamma delta T‐cell lymphoma [PDF]
eJHaem, 2022 Yoshikazu Hori +5 more
doaj +2 more sources