Results 21 to 30 of about 200,887 (335)

Gamma/Delta T Cell Lymphoma

Internal Medicine, 2004
A 54-year-old woman complained of fever and hepato-splenomegaly. The pathological findings of a liver biopsy specimen revealed the infiltration of lymphocytes in the sinusoids and that of the laparoscopically resected spleen revealed the infiltration of lymphocytes in the red pulp, which was positive for CD3, CD43, CD45RO and T-cell intracellular ...
Akihiko, Taguchi, Mutsuko, Miyazaki, Shizu, Sakuragi, Kenji, Shinohara, Toshiaki, Kamei, Yusuke, Inoue   +5 more
openaire   +3 more sources

Plasticity of gamma delta T cells: impact on the anti-tumor response

Frontiers in Immunology, 2014
The tumor immune microenvironment contributes to tumor initiation, progression and response to therapy. Among the immune cell subsets that play a role in the tumor microenvironment, innate-like T cells that express T cell receptors composed of gamma and ...
Virginie eLafont, Françoise eSanchez, Emilie eLaprevotte, Henri-Alexandre eMichaud, Laurent eGros, Jean-François eEliaou, Jean-François eEliaou, Nathalie eBonnefoy   +7 more
doaj   +1 more source

3D structures inferred from cDNA clones identify the CD1D-Restricted γδ T cell receptor in dromedaries

Frontiers in Immunology, 2022
The Camelidae species occupy an important immunological niche within the humoral as well as cell mediated immune response. Although recent studies have highlighted that the somatic hypermutation (SHM) shapes the T cell receptor gamma (TRG) and delta (TRD)
Giovanna Linguiti, Vincenzo Tragni, Ciro Leonardo Pierri, Serafina Massari, Marie-Paule Lefranc, Rachele Antonacci, Salvatrice Ciccarese   +6 more
doaj   +1 more source

Gamma-delta (γδ) T-cell lymphoma – another case unclassifiable by World Health Organization classification: a case report

Journal of Medical Case Reports, 2017
Background We present a case of gamma-delta T-cell lymphoma that does not fit the current World Health Organization classifications. Case presentation A 74-year-old Caribbean-American woman presented with lymphocytosis, pruritus, and non-drenching night ...
Hemant Sindhu, Ruqin Chen, Hui Chen, Jonathan Wong, Rashid Chaudhry, Yin Xu, Jen C. Wang   +6 more
doaj   +1 more source

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients [PDF]

, 2019
Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). ROR gamma t, the key Thelperl7 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like T cells, including ...
Coudenys, Julie, Cypers, Heleen, Decruy, Tine, Elewaut, Dirk, Gyselbrecht, Lieve, Harcken, Christian, Hoyt, Kathleen, Hughes, Robert, Jacques, Peggy, Labadia, Mark E., Martens, Liesbet, Mortier, Céline, Nabozny, Gerald, Piette, Yves, Saeys, Yvan, Schryvers, Nadia, Smith, Dustin, Turner, Michael, Van Calenbergh, Serge, Van den Bosch, Filip, Van Gassen, Sofie, Varkas, Gaëlle, Venken, Koen, Verheugen, Eveline, Wahle, Joseph, Wang, Chao-Ting, Wayne, Anita L., Wittoek, Ruth   +27 more
core   +3 more sources

Sheep TRD@ locus consists of a large number of TRDV elements

Italian Journal of Animal Science, 2011
The T cell receptor (TcR) expressed on mature T lymphocytes is a disulphidelinked heterodimer composed of alpha and beta or gamma and delta glycoprotein subunits.
S. Ciccarese, S. Massari, G. Vonghia, A. Caputi Jambrenghi, D. Pagliarulo, R. Antonacci, L. Del Faro   +6 more
doaj   +1 more source

Reducing farnesyl diphosphate synthase levels activates Vγ9Vδ2 T cells and improves tumor suppression in murine xenograft cancer models

Frontiers in Immunology, 2022
Human Vγ9Vδ2 T cells are attractive candidates for cancer immunotherapy due to their potent capacity for tumor recognition and cytolysis of many tumor cell types.
Mei-Ling Liou, Tyler Lahusen, Haishan Li, Haishan Li, Lingzhi Xiao, C. David Pauza, C. David Pauza   +6 more
doaj   +1 more source

Blocking of EphA2 on Endometrial Tumor Cells Reduces Susceptibility to Vδ1 Gamma-Delta T-Cell-Mediated Killing. [PDF]

Front Immunol, 2021
Hudecek R, Kohlova B, Siskova I, Piskacek M, Knight A.   +4 more
europepmc   +3 more sources

Hepatosplenic Gamma/DeltaT-Cell Lymphoma Masquerading as Alcoholic Hepatitis and Methadone Withdrawal

Case Reports in Gastroenterology, 2007
Hepatosplenic gamma/delta T-cell lymphoma is a rare neoplasm of mature gamma/delta T-cells with sinusoidal infiltration of spleen, liver, and bone marrow.
H.A. Lopez Morra, S.N. Fine, G. Dickstein   +2 more
doaj   +1 more source

Human peripheral CD4+ Vdelta1+ gamma delta T cells can develop into alpha beta T cells

Frontiers in Immunology, 2014
The lifelong generation of alpha beta T cells enables us to continuously build immunity against pathogens and malignancies despite the loss of thymic function with age. Consequently, alpha beta T-cell development has to occur independently of the thymus.
Hendrik eZiegler, Christian eWelker, Marco eSterk, Jan eHaarer, Hans-Georg eRammensee, Rupert eHandgretinger, Karin eSchilbach   +6 more
doaj   +1 more source