Results 101 to 110 of about 13,532 (284)

CLEC18A interacts with sulfated glycosaminoglycans and controls clear cell renal cell carcinoma progression

open access: yesThe FEBS Journal, EarlyView.
CLEC18A is a previously poorly characterized C‐type lectin. We mapped the expression of CLEC18A to the proximal tubule of the kidney and found CLEC18A to interact with sulfated glycosaminoglycans on proteoglycans. Furthermore, we found that CLEC18A plays an important role in hindering the progression of clear cell renal cell carcinomas in humans and in
Gustav Jonsson   +10 more
wiley   +1 more source

Structural insights into how vacuolar sorting receptor recognizes the C‐terminal sorting determinant of a vicilin‐like seed storage protein

open access: yesThe FEBS Journal, EarlyView.
Soluble cargo proteins are sorted to the vacuoles via a receptor‐mediated mechanism. Combining crystallographic and mutagenesis studies, we showed how the C‐terminal sorting determinant (ctVSD) of vicilin‐like seed storage protein VL22 is recognized by the protease‐associated domain of Arabidopsis vacuolar‐sorting receptor 1.
Shu Nga Lui   +4 more
wiley   +1 more source

Clinical Characteristics and Long‐Term Prognosis of Primary Biliary Cholangitis in Japan: Results of the 2nd‐Generation Nationwide Survey

open access: yesHepatology Research, EarlyView.
We have established the 2nd‐generation nationwide survey of PBC in Japan. Our analyses of the survey result not only highlight the demographical trend in Japanese PBC patients over time; they also validate the previously described risk factors for the patients' prognoses.
Yuki Kugiyama   +17 more
wiley   +1 more source

COVID-19 severity prediction in patients with chronic hepatitis C depending on the liver fibrosis stage

open access: yesВестник медицинского института «Реавиз»: Реабилитация, врач и здоровье
The aim of the study was to develop a method for assessing the risk of severity of the novel coronavirus infection COVID-19 in patients with chronic hepatitis C depending on the severity of liver fibrosis.Object and methods.
E. N. Temnik   +3 more
doaj   +1 more source

Allogeneic haematopoietic cell transplant in cutaneous T‐cell lymphomas: Recommendations from the EBMT PH&G Committee

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
This EBMT Practice Harmonisation and Guidelines Committee consensus provides practical recommendations for the selection, timing and conduct of allogeneic transplantation in advanced‐stage mycosis fungoides and Sézary syndrome, aiming to optimize outcomes through early multidisciplinary collaboration and evidence‐based decision‐making.
Gandhi Damaj   +26 more
wiley   +1 more source

Spatial Transcriptomics of Developing Wheat Seed Reveals Concentric Gene Expression Zones and Subgenome Biased Expression of Key Genes

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT Gene expression of developing seeds drives essential processes such as nutrient storage, stress tolerance and germination. However, the spatial organisation of gene expression within the complex structure of the seed remains largely unexplored.
Tori Millsteed   +7 more
wiley   +1 more source

The role of acquired host immunity in periodontal diseases

open access: yesPeriodontology 2000, EarlyView.
Abstract The aim of this narrative review is to relate the contribution of European researchers to the complex topic of the host immune system in periodontal disease, focusing on acquired immunity. Other chapters in this volume will address the genetics and autoantibody responses and other forms of immunity to periodontal disease.
Denis F. Kinane   +2 more
wiley   +1 more source

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