Yin and yang of interleukin-17 in host immunity to infection [version 1; referees: 2 approved] [PDF]
, 2017 The interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play important protective roles in host immune response to a variety of infections such as bacterial, fungal, parasitic, and viral.
Das, Shibali, Khader, Shabaana
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A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infections. [PDF]
PLoS Pathogens, 2009 Vgamma9/Vdelta2 T cells are a minor subset of T cells in human blood and differ from other T cells by their immediate responsiveness to microbes. We previously demonstrated that the primary target for Vgamma9/Vdelta2 T cells is (E)-4-hydroxy-3-methyl-but-
Matthias Eberl +5 more
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Comparison of porcine CD4 and gamma-delta T cell systemic and mucosal responses to the spirochete Brachyspira hyodysenteriae [PDF]
, 2002 In pigs, alphabeta CD4+ and gammadelta T cells constitute an important fraction of the circulating lymphocyte pool. This makes porcine an ideal animal model for functional studies of the two cell populations.
Hontecillas-Magarzo, Raquel
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The Role of Gamma-Delta T Cells in Diseases of the Central Nervous System
Frontiers in Immunology, 2020 Gamma-delta (γδ) T cells are a subset of T cells that promote the inflammatory responses of lymphoid and myeloid lineages, and are especially vital to the initial inflammatory and immune responses.
Jin Wo +5 more
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RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients [PDF]
, 2019 Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). ROR gamma t, the key Thelperl7 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like T cells, including ...
Coudenys, Julie +27 more
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Viruses, 2020 Recent advances in γδ T cell biology have focused on the unique attributes of these cells and their role in regulating innate and adaptive immunity, promoting tissue homeostasis, and providing resistance to various disorders. Numerous bacterial and viral
Shivkumar Biradar +2 more
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CD4 T cells but not Th17 cells are Required for Mouse Lung Transplant Obliterative Bronchiolitis [PDF]
, 2015 Lung transplant survival is limited by obliterative bronchiolitis (OB), but the mechanisms of OB development are unknown. Previous studies in a mouse model of orthotopic lung transplantation suggested a requirement for IL-17. We have used this orthotopic
Cummings, Oscar W. +9 more
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Cell Reports, 2019 Summary: Inflammatory bowel disease (IBD) is a complex autoimmune disorder recently shown to be associated with SUMOylation, a post-translational modification mechanism.
Aamir Suhail +8 more
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Activated monocytes augment TRAIL-mediated cytotoxicity by human NK cells through release of IFN-gamma [PDF]
, 2013 Natural killer (NK) cells are innate lymphocytes that are able to directly kill tumor cells through different mechanisms including ligation of TNF-related apoptosis-inducing ligand (TRAIL) receptors.
Bauer +31 more
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