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Gammadelta T cells and Mycobacterium tuberculosis.
Microbes and infection, 2000Since the first descriptions of mycobacterial reactivity for gammadelta T cells in 1989, studies of gammadelta T-cell responses to M. tuberculosis in humans and animal models have increased our understanding of the complex role(s) of this T-cell subset not only in the immune response to M.
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Gammadelta T Cells: Unconventional T Cells Involved in IBD Pathogenesis
Digestive Diseases and Sciences, 2018Ignacio, Catalan-Serra +3 more
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gammadelta T cells develop independently of Aire.
Cellular immunology, 2009Mutations in the transcriptional regulator Aire disrupt thymic alphabeta T cell selection, causing in humans Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). However, it is not known whether Aire is needed for normal gammadelta T cell development.
Heli, Tuovinen +6 more
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[gammadelta T cells stimulated by zoledronate kill osteosarcoma cells].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2011To investigate the cytotoxicity of human γδT cells from PBMCs stimulated by zoledronate against osteosarcoma cell line HOS in vitro and in vivo and evaluate the relavent pathways.The peripheral blood mononuclear cells (PBMCs)of healthy donors were stimulated by single dose zoledronate and cultured in the present of IL-2 for two weeks, analysising the ...
Hui, Jiang +5 more
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gammadelta T cell selection: is anyone useless?
Immunity, 2008In this issue of Immunity, a study by Jensen et al. (2008) suggests that T cell-receptor engagement during development affects gammadelta T cell polarization toward either interferon-gamma or interleukin-17 production. This might underlie their unique innate ability to regulate inflammation.
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly
Regulation of cutaneous malignancy by gammadelta T cells.
Science (New York, N.Y.), 2001The localization of gammadelta T cells within epithelia suggests that these cells may contribute to the down-regulation of epithelial malignancies. We report that mice lacking gammadelta cells are highly susceptible to multiple regimens of cutaneous carcinogenesis.
Girardi, M +9 more
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Alphabeta T-cell receptor engineered gammadelta T cells mediate effective antileukemic reactivity.
Cancer research, 2006Retroviral transfer of T-cell receptors (TCR) to peripheral blood-derived T cells generates large numbers of T cells with the same antigen specificity, potentially useful for adoptive immunotherapy. One drawback of this procedure is the formation of mixed TCR dimers with unknown specificities due to pairing of endogenous and introduced TCR chains.
Lars T, van der Veken +5 more
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Immunosurveillance and immunoregulation by gammadelta T cells.
The Journal of investigative dermatology, 2006Whereas the vast majority of T cells express a T-cell receptor (TCR) composed of alphabeta heterodimers, a smaller population expresses a gammadelta TCR. In contrast to alphabeta T cells, gammadelta T cells show less TCR diversity, are particularly enriched at epithelial surfaces and appear to respond to self-molecules that signal potential danger or ...
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Antigen recognition determinants of gammadelta T cell receptors.
Science (New York, N.Y.), 2005The molecular basis of gammadelta T cell receptor (TCR) recognition is poorly understood. Here, we analyze the TCR sequences of a natural gammadelta T cell population specific for the major histocompatibility complex class Ib molecule T22. We find that T22 recognition correlates strongly with a somatically recombined TCRdelta complementarity ...
Sunny, Shin +6 more
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