Results 161 to 170 of about 13,834,757 (208)

Immunosurveillance and immunoregulation by gammadelta T cells.

The Journal of investigative dermatology, 2006
Whereas the vast majority of T cells express a T-cell receptor (TCR) composed of alphabeta heterodimers, a smaller population expresses a gammadelta TCR. In contrast to alphabeta T cells, gammadelta T cells show less TCR diversity, are particularly enriched at epithelial surfaces and appear to respond to self-molecules that signal potential danger or ...
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Gammadelta T cells present antigen to CD4+ alphabeta T cells.

Journal of leukocyte biology, 1998
Gammadelta and alphabeta TCR+ T cells share many properties and their interactions are likely to be coordinated and regulated. We provide evidence that cattle gammadelta T cells are able to present antigen to CD4+ T cells. To help elucidate their function gammadelta T cell lines were propagated for extensive characterization.
R A, Collins, D, Werling, S E, Duggan, A P, Bland, K R, Parsons, C J, Howard   +5 more
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gammadelta T cells in malaria infections.

Parasitology today (Personal ed.), 2005
The association of a pronounced gammadelta T-cell response with Plasmodium infections is intriguing. The ability of parasite material to activate gammadelta T cells in vitro, and the localization of these cells in vivo in the red pulp of the spleen, suggests that these cells could play a role in the killing of bloodstage malaria parasites. However, the
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Generation of human gammadelta T-cell repertoires.

Critical reviews in immunology, 2000
The nature of how the human gammadelta T-cell repertoire is generated during normal development is poorly understood. Unlike TCR -alphabeta+ cells that are almost exclusively dependent upon the thymus for their development and maturation, gammadelta T cells can be generated in extrathymic sites.
L D, McVay, S R, Carding
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The role of gammadelta T cells in the airways.

Journal of molecular medicine (Berlin, Germany), 2001
Based on their T cell receptor expression two distinct T cell populations have been identified and designated as alphabeta and gammadelta T cells. While the specific role of alphabeta T cells is well understood, the specific function of gammabeta T cells remains elusive.
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Production of a soluble gammadelta T-cell receptor to identify ligands for the murine intestinal intraepithelial gammadelta T cell population.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003
Although the functions and antigen recognition requirements of alphabeta T cells are well characterised, the antigens recognised by gammadelta T cells and the consequences of this recognition are unclear. gammadelta T cells are enriched within epithelia, where they eradicate transformed epithelial cells and regulate inflammation. To understand how this
Steele, C R, Van Remoortere, K C, Hayday, A C   +2 more
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gammadelta T-cell receptors: functional correlations.

Immunological reviews, 2007
The gammadelta T-cell receptors (TCRs) are limited in their diversity, suggesting that their natural ligands may be few in number. Ligands for gammadeltaTCRs that have thus far been determined are predominantly of host rather than foreign origin. Correlations have been noted between the Vgamma and/or Vdelta genes a gammadelta T cell expresses and its ...
Rebecca L, O'Brien, Christina L, Roark, Niyun, Jin, M Kemal, Aydintug, Jena D, French, Jennifer L, Chain, J M, Wands, Molly, Johnston, Willi K, Born   +8 more
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Perspectives of gammadelta T cells in tumor immunology.

Cancer research, 2007
Subsets of human gammadelta T cells recognize tumor cell-expressed ligands that are not seen by the T-cell receptor of conventional alphabeta T cells. Vdelta1 T cells recognize MHC class I chain-related molecules A and B and UL-16-binding proteins expressed at variable levels on epithelial tumor cells and some leukemias and lymphomas.
Dieter, Kabelitz, Daniela, Wesch, Wei, He   +2 more
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Gammadelta T cells and Mycobacterium tuberculosis.

Microbes and infection, 2000
Since the first descriptions of mycobacterial reactivity for gammadelta T cells in 1989, studies of gammadelta T-cell responses to M. tuberculosis in humans and animal models have increased our understanding of the complex role(s) of this T-cell subset not only in the immune response to M.
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gammadelta T cells: a new frontier for immunotherapy?

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2005
The use of cytolytic effector cells as therapy for malignant disease has been a central focus of basic and clinical research for nearly 2 decades. Since the original descriptions of in vitro lymphocyte-mediated cytotoxicity against human tumor cells, there have been numerous attempts to exploit such observations for therapeutic use, with decidedly ...
Lawrence S, Lamb, Richard D, Lopez
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