Results 161 to 170 of about 8,798 (217)

Gammadelta T cell receptors without a job.

Immunity, 2009
In this issue of Immunity, the studies by Sutton et al. (2009) and Martin et al. (2009) indicate that gammadelta T cells are innate cells that rapidly produce interleukin (IL)-17 in response to cytokines or pathogens without the need for T cell receptor engagement.
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gammadelta T-cell receptors: functional correlations.

Immunological reviews, 2007
The gammadelta T-cell receptors (TCRs) are limited in their diversity, suggesting that their natural ligands may be few in number. Ligands for gammadeltaTCRs that have thus far been determined are predominantly of host rather than foreign origin. Correlations have been noted between the Vgamma and/or Vdelta genes a gammadelta T cell expresses and its ...
Rebecca L, O'Brien, Christina L, Roark, Niyun, Jin, M Kemal, Aydintug, Jena D, French, Jennifer L, Chain, J M, Wands, Molly, Johnston, Willi K, Born   +8 more
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Gammadelta T cells recognize tumor cells via CDR3delta region.

Molecular immunology, 2007
The principles governing gammadelta T cell specificity and diversity remain unclear due to lack of detailed structural analysis. To elucidate key structural basis of the specificity of gammadelta TCR for tumors, we analyzed the binding activities of synthesized TCR Vdelta2 CDR3 peptides derived from tumor infiltrating lymphocyte (TIL) s in ovarian ...
Chunping, Xu, Huiyuan, Zhang, Hongbo, Hu, Hongbin, He, Zhun, Wang, Yong, Xu, Hui, Chen, Wei, Cao, Sumei, Zhang, Lianxian, Cui, Denian, Ba, Wei, He   +11 more
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Antigen recognition by gammadelta T cells.

Immunological reviews, 2007
gammadelta T cells contribute to host immune competence uniquely. This is most likely because they have distinctive antigen-recognition properties. While the basic organization of gammadelta T-cell receptor (TCR) loci is similar to that of alphabeta TCR loci, there is a striking difference in how the diversity of gammadelta TCRs is generated ...
Yueh-hsiu, Chien, Yves, Konigshofer
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Heterogeneity of avian gammadelta T cells.

Veterinary immunology and immunopathology, 2008
gammadelta T cells are distinct with respect to tissue localisation, phenotype and biological functions and similarities between species are not very apparent. To elucidate local and functional heterogeneity of non-stimulated avian gammadelta T cells, the CD8-characterised gammadelta T cell subsets [CD8alpha(+high) (CD8alphaalpha(+) and CD8alphabeta(+))
Jana, Pieper, Ulrich, Methner, Angela, Berndt   +2 more
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Antigen-restricted gammadelta T-cell receptors?

Archivum immunologiae et therapiae experimentalis, 2009
After more than two decades of investigation, the biological role of the gammadelta T-cell receptors (TCRs) remains elusive. In fact, a theory of ligand recognition is still lacking that accounts for their adaptable structure, their peripheral selection, and the observed responses of gammadelta T cells, which do not require immunization but only ...
Willi K, Born, Rebecca L, O'Brien
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Antiviral reactivities of gammadelta T cells.

Microbes and infection, 2005
The complex antiviral immune mechanisms involve both adaptive and innate reactions mediated by gammadelta T lymphocytes, whose unique immunosurveillance contributions are analyzed here in different clinical and experimental settings. It is beyond any doubt that the fast, potent, cytotoxic as well as non-cytolytic antiviral activities of gammadelta T ...
Fabrizio, Poccia, Chiara, Agrati, Federico, Martini, Maria Rosaria, Capobianchi, Marianne, Wallace, Miroslav, Malkovsky   +5 more
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Gammadelta T cells - innate immune lymphocytes?

Current opinion in immunology, 2007
It is unclear what the antigen recognition determinants of gammadelta T-cell receptors (TCRs) are. Compared with immunoglobulin and alphabeta TCRs, gammadelta TCRs have the highest potential CDR3 diversity generated by VDJ recombination. However, gammadelta T-cell reactivities seem to segregate with V gene usage, which has been taken to suggest that ...
Yves, Konigshofer, Yueh-hsiu, Chien
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Gammadelta T cells present antigen to CD4+ alphabeta T cells.

Journal of leukocyte biology, 1998
Gammadelta and alphabeta TCR+ T cells share many properties and their interactions are likely to be coordinated and regulated. We provide evidence that cattle gammadelta T cells are able to present antigen to CD4+ T cells. To help elucidate their function gammadelta T cell lines were propagated for extensive characterization.
R A, Collins, D, Werling, S E, Duggan, A P, Bland, K R, Parsons, C J, Howard   +5 more
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Anti-lymphoma effect of gammadelta T cells.

Leukemia & lymphoma, 2005
During the last few years, our knowledge about the activation and control of non-major histocompatibility complex (MHC)-restricted innate effector lymphocytes (such as natural killer (NK) cells, NK T cells and gammadelta T cells) has advanced enormously and immunotherapeutic strategies based on these cell types receive more and more attention.
Volker, Kunzmann, Martin, Wilhelm
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