Results 181 to 190 of about 8,798 (217)

[gammadelta T cells stimulated by zoledronate kill osteosarcoma cells].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2011
To investigate the cytotoxicity of human γδT cells from PBMCs stimulated by zoledronate against osteosarcoma cell line HOS in vitro and in vivo and evaluate the relavent pathways.The peripheral blood mononuclear cells (PBMCs)of healthy donors were stimulated by single dose zoledronate and cultured in the present of IL-2 for two weeks, analysising the ...
Hui, Jiang, Qiang, Xu, Chao, Yang, Zhen-Guo, Cao, Zhao-Xu, Li, Zhao-Ming, Ye   +5 more
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gammadelta T cell selection: is anyone useless?

Immunity, 2008
In this issue of Immunity, a study by Jensen et al. (2008) suggests that T cell-receptor engagement during development affects gammadelta T cell polarization toward either interferon-gamma or interleukin-17 production. This might underlie their unique innate ability to regulate inflammation.
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Regulation of cutaneous malignancy by gammadelta T cells.

Science (New York, N.Y.), 2001
The localization of gammadelta T cells within epithelia suggests that these cells may contribute to the down-regulation of epithelial malignancies. We report that mice lacking gammadelta cells are highly susceptible to multiple regimens of cutaneous carcinogenesis.
Girardi, M, Oppenheim, D E, Steele, C R, Lewis, J M, Glusac, E, Filler, R, Hobby, P, Sutton, B, Tigelaar, R E, Hayday, A C   +9 more
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Alphabeta T-cell receptor engineered gammadelta T cells mediate effective antileukemic reactivity.

Cancer research, 2006
Retroviral transfer of T-cell receptors (TCR) to peripheral blood-derived T cells generates large numbers of T cells with the same antigen specificity, potentially useful for adoptive immunotherapy. One drawback of this procedure is the formation of mixed TCR dimers with unknown specificities due to pairing of endogenous and introduced TCR chains.
Lars T, van der Veken, Renate S, Hagedoorn, Marleen M, van Loenen, Roel, Willemze, J H Frederik, Falkenburg, Mirjam H M, Heemskerk   +5 more
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Immunosurveillance and immunoregulation by gammadelta T cells.

The Journal of investigative dermatology, 2006
Whereas the vast majority of T cells express a T-cell receptor (TCR) composed of alphabeta heterodimers, a smaller population expresses a gammadelta TCR. In contrast to alphabeta T cells, gammadelta T cells show less TCR diversity, are particularly enriched at epithelial surfaces and appear to respond to self-molecules that signal potential danger or ...
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Antigen recognition determinants of gammadelta T cell receptors.

Science (New York, N.Y.), 2005
The molecular basis of gammadelta T cell receptor (TCR) recognition is poorly understood. Here, we analyze the TCR sequences of a natural gammadelta T cell population specific for the major histocompatibility complex class Ib molecule T22. We find that T22 recognition correlates strongly with a somatically recombined TCRdelta complementarity ...
Sunny, Shin, Ramy, El-Diwany, Steven, Schaffert, Erin J, Adams, K Christopher, Garcia, Pablo, Pereira, Yueh-Hsiu, Chien   +6 more
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[A case of hepatosplenic gammadelta T cell lymphoma].

Zhongguo shi yan xue ye xue za zhi, 2008
Hepatosplenic gammadelta T cell lymphoma represents rare, often aggressive type of malignant peripheral T-cell lymphoma, which is characterized by expressing T-cell-associated markers CD2, CD3 and gammadelta T-cell receptor, and nonactivated cytotoxic cell phenotype (TIA-1+, granzyme B-).
Fu-Xu, Wang, Xue-Jun, Zhang, Zuo-Ren, Dong   +2 more
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To be gammadelta or not to be gammadelta? Signaling pathways in alphabeta versus gammadelta T cell maturation.

Science signaling, 2010
Maturation of T cells in the thymus involves input from a number of signaling pathways; their combined input determines whether thymic precursor cells will differentiate into mature alphabeta or gammadelta T cells. This Journal Club article highlights recent research showing that the role of Notch signaling in human T cell maturation differs from that ...
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Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies

Nature Reviews Drug Discovery, 2019
Zsolt Sebestyén, Immo Prinz, Julie Déchanet-Merville   +2 more
exaly  

γδ T cells in tissue physiology and surveillance

Nature Reviews Immunology, 2020
Bruno Silva-Santos
exaly