Results 171 to 180 of about 13,834,757 (208)

Gammadelta T Cells: Unconventional T Cells Involved in IBD Pathogenesis

Digestive Diseases and Sciences, 2018
Ignacio, Catalan-Serra, Juan Carlos, Andreu-Ballester, Torunn, Bruland, Arne Kristian, Sandvik   +3 more
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Function of intestinal gammadelta T cells.

Immunologic research, 2000
Mucosal tissues including the intestine, lung, reproductive tract, and skin form the major interfaces between the outside and internal milieus. Facing the outside is an epithelial cell layer, the epithelium, built on a vascular connective surface. In addition to performing specialized functions, mucosal tissues are sites where immune, epithelial, and ...
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gammadelta T cells develop independently of Aire.

Cellular immunology, 2009
Mutations in the transcriptional regulator Aire disrupt thymic alphabeta T cell selection, causing in humans Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). However, it is not known whether Aire is needed for normal gammadelta T cell development.
Heli, Tuovinen, Nora, Pöntynen, Mikhail, Gylling, Eliisa, Kekäläinen, Jaakko, Perheentupa, Aaro, Miettinen, T Petteri, Arstila   +6 more
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The function of gammadelta T cells in innate immunity.

Current opinion in immunology, 2006
Many researchers believe that gammadelta T lymphocytes belong somewhere 'in-between' the innate and adaptive immune systems. Recent studies strongly emphasize the innate features and functions of these cells, including the use of germline elements of the T cell receptor for ligand recognition, segregation into functionally specialized cell populations ...
Willi K, Born, Christopher L, Reardon, Rebecca L, O'Brien   +2 more
openaire   +1 more source

Gammadelta T cells - innate immune lymphocytes?

Current opinion in immunology, 2007
It is unclear what the antigen recognition determinants of gammadelta T-cell receptors (TCRs) are. Compared with immunoglobulin and alphabeta TCRs, gammadelta TCRs have the highest potential CDR3 diversity generated by VDJ recombination. However, gammadelta T-cell reactivities seem to segregate with V gene usage, which has been taken to suggest that ...
Yves, Konigshofer, Yueh-hsiu, Chien
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gammadelta T cells as regulators of airway hyperresponsiveness.

International archives of allergy and immunology, 2001
Airway responsiveness (AR) is determined by complex mechanisms reflecting lung responses to airborne stimuli. Murine studies have identified a number of potential factors modulating AR and thus have contributed to the current understanding of these mechanisms.
M, Lahn, A, Kanehiro, K, Takeda, A, Konowal, R L, O'Brien, E W, Gelfand, W K, Born   +6 more
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Hepatosplenic and other gammadelta T-cell lymphomas.

American journal of clinical pathology, 2007
The 2005 Society for Hematopathology/European Association for Haematopathology Workshop session 11 was dedicated to hepatosplenic T-cell lymphoma (HSTCL). HSTCL is a rare aggressive type of extranodal lymphoma characterized by hepatosplenomegaly, bone marrow involvement, and peripheral blood cytopenias.
Francisco, Vega, L Jeffrey, Medeiros, Philippe, Gaulard   +2 more
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A retrospective on the requirements for gammadelta T-cell development.

Immunological reviews, 2007
Since the discovery of gammadelta T cells two decades ago, considerable effort has been made to understand their developmental program, their antigen specificity, and their contribution to the immune response. In this review, we focus on what is known about gammadelta T-cell development and on the advances that have been made in determining which genes
Sandra M, Hayes, Paul E, Love
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gammadelta T-cell lymphomas: a homogeneous entity?

Histopathology, 2000
gammadelta T-cells comprise an immunologically distinct lymphoid population, characterized by specific morphological, phenotypical and functional properties. Therefore it seems reasonable to speculate that neoplasms derived from this particular T-cell subset display distinct features.
C, de Wolf-Peeters, R, Achten
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[A case of hepatosplenic gammadelta T cell lymphoma].

Zhongguo shi yan xue ye xue za zhi, 2008
Hepatosplenic gammadelta T cell lymphoma represents rare, often aggressive type of malignant peripheral T-cell lymphoma, which is characterized by expressing T-cell-associated markers CD2, CD3 and gammadelta T-cell receptor, and nonactivated cytotoxic cell phenotype (TIA-1+, granzyme B-).
Fu-Xu, Wang, Xue-Jun, Zhang, Zuo-Ren, Dong   +2 more
openaire   +1 more source