Results 141 to 150 of about 2,337 (177)

gammadelta T cells: a new frontier for immunotherapy?

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2005
The use of cytolytic effector cells as therapy for malignant disease has been a central focus of basic and clinical research for nearly 2 decades. Since the original descriptions of in vitro lymphocyte-mediated cytotoxicity against human tumor cells, there have been numerous attempts to exploit such observations for therapeutic use, with decidedly ...
Lawrence S, Lamb, Richard D, Lopez
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The role of gammadelta T cells in the airways.

Journal of molecular medicine (Berlin, Germany), 2001
Based on their T cell receptor expression two distinct T cell populations have been identified and designated as alphabeta and gammadelta T cells. While the specific role of alphabeta T cells is well understood, the specific function of gammabeta T cells remains elusive.
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Gammadelta T cells: functional plasticity and heterogeneity.

Nature reviews. Immunology, 2002
Gammadelta T cells remain an enigma. They are capable of generating more unique antigen receptors than alphabeta T cells and B cells combined, yet their repertoire of antigen receptors is dominated by specific subsets that recognize a limited number of antigens. A variety of sometimes conflicting effector functions have been ascribed to them, yet their
Carding, Simon R, Egan, Paul J
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Anti-lymphoma effect of gammadelta T cells.

Leukemia & lymphoma, 2005
During the last few years, our knowledge about the activation and control of non-major histocompatibility complex (MHC)-restricted innate effector lymphocytes (such as natural killer (NK) cells, NK T cells and gammadelta T cells) has advanced enormously and immunotherapeutic strategies based on these cell types receive more and more attention.
Volker, Kunzmann, Martin, Wilhelm
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Antigen-restricted gammadelta T-cell receptors?

Archivum immunologiae et therapiae experimentalis, 2009
After more than two decades of investigation, the biological role of the gammadelta T-cell receptors (TCRs) remains elusive. In fact, a theory of ligand recognition is still lacking that accounts for their adaptable structure, their peripheral selection, and the observed responses of gammadelta T cells, which do not require immunization but only ...
Willi K, Born, Rebecca L, O'Brien
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Regulation of cutaneous malignancy by gammadelta T cells.

Science (New York, N.Y.), 2001
The localization of gammadelta T cells within epithelia suggests that these cells may contribute to the down-regulation of epithelial malignancies. We report that mice lacking gammadelta cells are highly susceptible to multiple regimens of cutaneous carcinogenesis.
Girardi, M, Oppenheim, D E, Steele, C R, Lewis, J M, Glusac, E, Filler, R, Hobby, P, Sutton, B, Tigelaar, R E, Hayday, A C   +9 more
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A retrospective on the requirements for gammadelta T-cell development.

Immunological reviews, 2007
Since the discovery of gammadelta T cells two decades ago, considerable effort has been made to understand their developmental program, their antigen specificity, and their contribution to the immune response. In this review, we focus on what is known about gammadelta T-cell development and on the advances that have been made in determining which genes
Sandra M, Hayes, Paul E, Love
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gammadelta T cells as regulators of airway hyperresponsiveness.

International archives of allergy and immunology, 2001
Airway responsiveness (AR) is determined by complex mechanisms reflecting lung responses to airborne stimuli. Murine studies have identified a number of potential factors modulating AR and thus have contributed to the current understanding of these mechanisms.
M, Lahn, A, Kanehiro, K, Takeda, A, Konowal, R L, O'Brien, E W, Gelfand, W K, Born   +6 more
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Production of a soluble gammadelta T-cell receptor to identify ligands for the murine intestinal intraepithelial gammadelta T cell population.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003
Although the functions and antigen recognition requirements of alphabeta T cells are well characterised, the antigens recognised by gammadelta T cells and the consequences of this recognition are unclear. gammadelta T cells are enriched within epithelia, where they eradicate transformed epithelial cells and regulate inflammation. To understand how this
Steele, C R, Van Remoortere, K C, Hayday, A C   +2 more
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The function of gammadelta T cells in innate immunity.

Current opinion in immunology, 2006
Many researchers believe that gammadelta T lymphocytes belong somewhere 'in-between' the innate and adaptive immune systems. Recent studies strongly emphasize the innate features and functions of these cells, including the use of germline elements of the T cell receptor for ligand recognition, segregation into functionally specialized cell populations ...
Willi K, Born, Christopher L, Reardon, Rebecca L, O'Brien   +2 more
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