Results 11 to 20 of about 44,210 (231)

Reversion of Val(Ganciclovir)-Resistance-Associated Mutations in Two SOT Patients with Mismatched Serostatus for CMV (D+/R-) [PDF]

Viruses
The emergence of drug-resistant cytomegalovirus (CMV) complicates viral response to therapy. We present two cases of solid organ transplant (SOT) recipients, highlighting the reversion of UL97 mutations associated with val(ganciclovir) resistance ...
Elena Seminari, Alessandra Tebaldi, Aurelia Sangani, Paola Giordani, Daniele Lilleri, Stefania Paolucci, Giulia Campanini, Elizabeth Iskandar, Fausto Baldanti, Raffaele Bruno   +9 more
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Acute Herpetic Keratitis: What is the Role for Ganciclovir Ophthalmic Gel? [PDF]

Ophthalmology and Eye Diseases, 2012
Herpes simplex keratitis (HSK) is a major cause of corneal blindness in the world. Following the primary infection, the virus enters into a latent phase.
Afsun Sahin, Pedram Hamrah
doaj   +4 more sources

Efficacy and toxicity analysis of ganciclovir in patients with cytomegalovirus lung infection: what is new for target range of therapeutic drug monitoring [PDF]

Microbiology Spectrum
To investigate the relationship between ganciclovir trough concentration and its clinical efficacy and safety in patients with pulmonary cytomegalovirus (CMV) infection and to evaluate the target value of therapeutic drug monitoring (TDM) for predicting ...
Dongjie Guo, Xiaoxing Wang, Pengmei Li, Yongguang Shang, Lei Zhang, Yue Chen, Xudong Kong, Wenqian Chen   +7 more
doaj   +2 more sources

Management of CMV encephalitis with persistent CSF CMV DNA in a patient with HIV: a case report of successful treatment with ganciclovir–foscarnet combination therapy [PDF]

BMC Infectious Diseases
Background Cytomegalovirus (CMV) is a common opportunistic pathogen in immunocompromised individuals and can lead to significant mortality and morbidity via end-organ involvements.
Elif Tanyel, Cengizhan Tanyel, Server Sena Ersarı, Derya Seyman, Hande Berk Cam   +4 more
doaj   +2 more sources

Extemporaneous Preparation of 20 mg/mL Ganciclovir in Artificial Tears in Comparison with Sterile Water for Ophthalmic Administration: Formulation and Stability Study

Pharmaceutics, 2023
Ganciclovir is available as a lyophilized powder for reconstitution and is normally used to treat ophthalmic viral infections. The use of ganciclovir in artificial tears containing hydrocolloid polymers may prove beneficial to patients during drug ...
Jiraporn Leanpolchareanchai, Patamaporn Tangteerakoon, Patcharin Supapsophon, Somsiri Sukavatcharin, Pornchai Simaroj, Jiraphong Suksiriworapong   +5 more
doaj   +1 more source

Ganciclovir Pharmacokinetics and Individualized Dosing Based on Covariate in Lung Transplant Recipients

Pharmaceutics, 2022
The aim of this prospective study was to evaluate the pharmacokinetics of ganciclovir in lung transplant recipients, to explore its covariates, and to propose an individualized dosing regimen.
Eliška Dvořáčková, Martin Šíma, Jakub Petrus, Eva Klapková, Petr Hubáček, Jiří Pozniak, Jan Havlín, Robert Lischke, Ondřej Slanař   +8 more
doaj   +1 more source

A preliminary study on the UL97 gene of cytomegalovirus isolated from patients suspected of ganciclovir resistance in Sri Lanka

Sri Lankan Journal of Infectious Diseases, 2023
Background: Human cytomegalovirus (HCMV) is an opportunistic virus causing infections in immunocompromised patients. The widespread use of ganciclovir to treat CMV infections has led to the development of ganciclovir resistance.
J. C. Thambyrajah, N. Fernando, V. Rathnayake, S. Handunnetti, J. Jayamaha   +4 more
doaj   +1 more source

The need for area under the curve measurements in the field of ganciclovir therapeutic drug monitoring in children: a case report

BMC Infectious Diseases, 2021
Background Ganciclovir pharmacokinetics is characterized by a high variability in drug exposure. Usually, monitoring of ganciclovir exposure is performed by measuring trough concentration.
Xavier Duval, Florian Lemaitre, Sophie Pertuisel, Jamie Probert, Virginie Gandemer, Marie-Clémence Verdier, Camille Tron   +6 more
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Development and Validation of Valganciclovir and its Active Metabolite Ganciclovir Determination in Human Plasma by HPLC-MS/MS Method

Разработка и регистрация лекарственных средств, 2021
Introduction. Currently, physicochemical methods of quantification are actively used to determine the content of drugs in biological fluids. High-performance liquid chromatography with various detection methods is particularly widespread. One of the most
T. N. Komarov, I. E. Shohin, M. A. Tokareva, O. A. Archakova, D. S. Bogdanova, A. V. Aleshina, N. S. Bagaeva, V. V. Davydanova   +7 more
doaj   +1 more source

Intensive Hemodiafiltration Successfully Removes Ganciclovir Overdose and Largely Exceeds Reported Elimination During Hemodialysis—A Case Report and Review of the Literature

Frontiers in Pharmacology, 2020
We present the case of a kidney transplant patient (Cockroft-Gault estimated creatinine clearance 14 ml/min) who was inadvertently eight-fold overdosed with a single dose of 500 mg intravenous ganciclovir.
Verena Gotta, Anne Leuppi-Taegtmeyer, Mirjam Gessler, Marc Pfister, Daniel Müller, Andreas Werner Jehle, Andreas Werner Jehle   +6 more
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