Results 21 to 30 of about 30,075 (198)

Population Pharmacokinetics of Ganciclovir in Allogeneic Hematopoietic Stem Cell Transplant Patients

, 2023
Treatment of cytomegalovirus (CMV) infection in allogeneic hematopoietic stem cell transplantation (alloHCT) patients with ganciclovir is complicated by toxicity and resistance.
Shakib, Sepehr, Selby, Philip RR, Roberts, Jason AA, Warner, Morgyn SS, Yeung, David, Wallis, Steven CC, Hahn, Uwe, Mcwhinney, Brett, Ungerer, Jacobus PJ, Heffernan, Aaron JJ, Peake, Sandra LL   +10 more
core   +1 more source

Population Pharmacokinetics and Dose Optimization of Ganciclovir in Critically Ill Children

Frontiers in Pharmacology, 2021
Objective: The present study aims to establish a population pharmacokinetic model of ganciclovir and optimize the dosing regimen in critically ill children suffering from cytomegalovirus related disease.Methods: A total of 104 children were included in ...
SiChan Li, Chang Shu, SanLan Wu, Hua Xu, Yang Wang   +4 more
doaj   +1 more source

Prevention of cytomegalovirus infection after solid organ transplantation: a Bayesian network analysis

Annals of Clinical Microbiology and Antimicrobials, 2020
Background Cytomegalovirus infection is one of the most common complications after solid organ transplantation. There have been several classes of antiviral drugs for the prevention of cytomegalovirus infection, such as acyclovir, valacyclovir ...
Yu Zhang, Tao Zhou, Mingzhu Huang, Guangxiang Gu, Qiang Xia   +4 more
doaj   +1 more source

Cytomegalovirus Inhibition by Pluronic-Encapsulated Quercetin and Synergy with Ganciclovir [PDF]

, 2020
Congenital cytomegalovirus (CMV) is the leading viral cause of birth defects worldwide and leads to a variety of complications. Ganciclovir is the most common anti-CMV drug used but often causes severe side effects. Quercetin, a plant pigment, shows anti-
Wadsworth, Ian
core   +1 more source

Efficacy and toxicity analysis of ganciclovir in patients with cytomegalovirus lung infection: what is new for target range of therapeutic drug monitoring

Microbiology Spectrum
To investigate the relationship between ganciclovir trough concentration and its clinical efficacy and safety in patients with pulmonary cytomegalovirus (CMV) infection and to evaluate the target value of therapeutic drug monitoring (TDM) for predicting ...
Dongjie Guo, Xiaoxing Wang, Pengmei Li, Yongguang Shang, Lei Zhang, Yue Chen, Xudong Kong, Wenqian Chen   +7 more
doaj   +1 more source

Intra-cameral level of ganciclovir gel, 0.15% following topical application for cytomegalovirus anterior segment infection: A pilot study.

PLoS ONE, 2018
PurposeTo investigate the intra-cameral level of ganciclovir following topical application of ganciclovir gel, 0.15% for cytomegalovirus (CMV) anterior segment infection.DesignNon-randomized, prospective, interventional clinical study.MethodsPatients ...
Samanthila Waduthantri, Lei Zhou, Soon-Phaik Chee   +2 more
doaj   +1 more source

Pharmacokinetics of Ganciclovir after Oral Valganciclovir versus Intravenous Ganciclovir in Allogeneic Stem Cell Transplant Patients with Graft-versus-Host Disease of the Gastrointestinal Tract [PDF]

, 2006
The pharmacokinetics of ganciclovir after oral valganciclovir versus intravenous ganciclovir were compared in allogeneic stem cell transplant recipients with stable graft-versus-host disease of the gastrointestinal tract.
Gabriel, Don A., Ratanatharathorn, Voravit, Winston, Drew J., Emmanouilides, Christos, Shaw, Leslie M., Baden, Lindsey R., Lange, W. Robert   +6 more
core   +1 more source

2% Ganciclovir Eye Drops Control Posner-Schlossman Syndrome Relapses With/Without Cytomegalovirus Intraocular Reactivation

Frontiers in Medicine, 2022
BackgroundTo observe and compare the efficacy of 2% ganciclovir eye drops in the treatment of Posner-Schlossman Syndrome relapses with/without cytomegalovirus intraocular reactivation.MethodsA prospective cohort study enrolling 101 patients diagnosed ...
Qilian Sheng, Qilian Sheng, Qilian Sheng, Ruyi Zhai, Ruyi Zhai, Ruyi Zhai, Xintong Fan, Xintong Fan, Xintong Fan, Xiangmei Kong, Xiangmei Kong, Xiangmei Kong   +11 more
doaj   +1 more source

Variable viral clearance despite adequate ganciclovir plasma levels during valganciclovir treatment for cytomegalovirus disease in D+/R- transplant recipients

BMC Infectious Diseases, 2010
Background Valganciclovir, the oral prodrug of ganciclovir, has been demonstrated equivalent to iv ganciclovir for CMV disease treatment in solid organ transplant recipients.
Buclin Thierry, Decosterd Laurent A, Sahli Roland, Venetz Jean-Pierre, Lamoth Frédéric, Manuel Oriol, Perrottet Nancy, Pascual Manuel, Meylan Pascal   +8 more
doaj   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source