Results 41 to 50 of about 40,022 (185)

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, EarlyView.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

The Advent Of Cytomegalovirus Infection In HIV Infected Patients: A review [PDF]

, 2004
Cytomegalovirus is considered as one among the long list of latent infections in humans that although normally controlled by the cellular immune response, gets activated after HIV infection takes its role on infecting the T4 lymphocytes. Clinical disease
Kirubakaran Isaac, Dr Sundar
core   +1 more source

Eccrine Squamous Syringometaplasia Mimicking Acute Cutaneous GVHD in a Pediatric HSCT Recipient: Case Report and Brief Review of the Indexed Literature

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Eccrine squamous syringometaplasia (ESS) is an uncommon reactive alteration of eccrine ducts, most often reported in oncologic and transplant settings, where it may clinically mimic acute cutaneous graft‐versus‐host disease (GVHD). We describe a 3‐year‐old boy with chronic granulomatous disease who developed a diffuse erythematous eruption 6 ...
Benedetta Galli, Cecilia Catapano, Iacopo Ghini, Mariateresa Rossi, Marina Venturini, Valeria Boccaletti   +5 more
wiley   +1 more source

Valganciclovir for cytomegalovirus prevention in solid organ transplant patients: an evidence-based reassessment of safety and efficacy. [PDF]

PLoS ONE, 2009
BACKGROUND:Several anti-viral drugs have demonstrated efficacy in preventing Cytomegalovirus (CMV) infections in solid organ transplant (SOT) patients.
Andre C Kalil, Alison G Freifeld, Elizabeth R Lyden, Julie A Stoner   +3 more
doaj   +1 more source

Development and implementation of a computerised clinical decision support system for hospital‐in‐the‐home patient identification

Internal Medicine Journal, EarlyView.
ABSTRACT Background Identification of appropriate patients for hospital‐in‐the‐home (HITH) remains a significant challenge. We hypothesise that a human‐centred design (HCD) approach can assist in developing a computerised clinical decision support system (CDSS) to address this issue via leveraging data within the electronic medical record (EMR).
Seok Ming Lim, Thomas Kitt‐Thompson, Douglas Forsyth Johnson, Michael Turner, Adam Boulton, Samantha Plumb, Daniel Capurro, Wen‐Kwang Lim   +7 more
wiley   +1 more source

Clinical Trials of Immunogene Therapy for Spontaneous Tumors in Companion Animals [PDF]

, 2014
Despite the important progress obtained in the treatment of some pets’ malignancies, new treatments need to be developed. Being critical in cancer control and progression, the immune system’s appropriate modulation may provide effective therapeutic ...
Finocchiaro, Liliana Maria Elena, Glikin, Gerardo Claudio   +1 more
core   +4 more sources

Infection Complications in Pediatric Patients With Inborn Errors of Immunity After Umbilical Cord Blood Transplantation: A Chinese Single‐Center Study

Transplant Infectious Disease, EarlyView.
This study reveals that infections are highly prevalent in pediatric IEI patients after umbilical cord blood transplantation, with early‐stage infections and bloodstream infections strongly associated with poorer survival. These findings advocate for risk‐stratified surveillance and preemptive strategies in high‐risk subgroups.
Zhongling Wei, Ping Wang, Wenjin Jiang, Jie Man, Ying Huang, Xiaochuan Wang, Hongsheng Wang, Xiaowen Qian, Xiaowen Zhai   +8 more
wiley   +1 more source

Low-dose ganciclovir ameliorates dextran sulfate sodium-induced ulcerative colitis through inhibiting macrophage STING activation in mice

Frontiers in Pharmacology, 2022
Ganciclovir (GCV) is a prodrug nucleoside analogue and is clinically used as antiviral drug for the treatment of cytomegalovirus (CMV) and other infections.
Lin-Kong Gong, Xiaodong Yang, Juan Yang, Shu Wu, Yue Chen, Jiang-Tao Zhang, Zhi-Hong Wang, Li-Hua Chen, Chungen Xing, Tong Liu, Tong Liu, Tong Liu   +11 more
doaj   +1 more source

Idiopathic AIDS enteropathy and treatment of gastrointestinal opportunistic pathogens. [PDF]

, 2009
Diarrhea in patients with acquired immune deficiency syndrome (AIDS) has proven to be both a diagnostic and treatment challenge since the discovery of the human immunodeficiency virus (HIV) virus more than 30 years ago.
Cello, John P, Day, Lukejohn W
core  

Therapeutic potential of bleomycin plus suicide or interferon-β gene transfer combination for spontaneous feline and canine melanoma [PDF]

, 2017
We originated and characterized melanoma cell lines derived from tumors of two feline and two canine veterinary patients. These lines reestablished the morphology, physiology and cell heterogeneity of their respective parental tumors.
Agnetti, Lucrecia, Finocchiaro, Liliana Maria Elena, Fondello, Chiara, Glikin, Gerardo Claudio, Villaverde, Marcela Solange   +4 more
core   +1 more source