Results 41 to 50 of about 30,075 (198)

Outcome of Cytomegalovirus Colitis in Inflammatory Bowel Disease with Different Regimes of Ganciclovir

Middle East Journal of Digestive Diseases, 2018
BACKGROUND Cytomegalovirus (CMV) infection is common in individuals with inflammatory bowel disease (IBD) and is responsible for relapse, increased severity, and poor outcome if left untreated. Ganciclovir is the mainstay of treatment but data regarding
Iftikhar Ahmed, Wael Kassem, Yazen Salam, Manuele Furnari, Tina Mehta   +4 more
doaj   +1 more source

Low-dose ganciclovir ameliorates dextran sulfate sodium-induced ulcerative colitis through inhibiting macrophage STING activation in mice

Frontiers in Pharmacology, 2022
Ganciclovir (GCV) is a prodrug nucleoside analogue and is clinically used as antiviral drug for the treatment of cytomegalovirus (CMV) and other infections.
Lin-Kong Gong, Xiaodong Yang, Juan Yang, Shu Wu, Yue Chen, Jiang-Tao Zhang, Zhi-Hong Wang, Li-Hua Chen, Chungen Xing, Tong Liu, Tong Liu, Tong Liu   +11 more
doaj   +1 more source

Long‐term results of brentuximab vedotin and bendamustine for first‐line treatment of Hodgkin lymphoma in the elderly (HALO trial)

British Journal of Haematology, EarlyView.
Summary The Hodgkin lymphoma treatment in the elderly (eHL) is a challenge due to a narrow therapeutic window between therapy effectiveness and toxicity. Both bendamustine (Be) and brentuximab vedotin (BV) are well‐tolerated, effective drugs in relapsing HL, but no data exist on Be‐BV frontline treatment in eHL.
Andrea Gallamini, Simonetta Viviani, Davide Rapezzi, Caterina Patti, Pierre Feugier, Alessandro Rambaldi, Fontanet Bijou, Anna Borra, Cécile Borel, Tanguy Pace‐Loscos, Renaud Schiappa, Stephane Chauvie, Colin Debaigt, Anna Guidetti, Olivier Humbert, Jean‐Marc Schiano De Colella   +15 more
wiley   +1 more source

Antiadenoviral effects of ganciclovir in types inducing keratoconjunctivitis by quantitative polymerase chain reaction methods

Clinical Ophthalmology, 2014
Jane Huang,1 Kazuaki Kadonosono,2 Eiichi Uchio1 1Department of Ophthalmology, Fukuoka University School of Medicine, Fukuoka, 2Department of Ophthalmology, Yokohama City University Medical Center, Yokohama, Japan Purpose: The most common external ocular
Huang J, Kadonosono K, Uchio E
doaj  

Valganciclovir for cytomegalovirus prevention in solid organ transplant patients: an evidence-based reassessment of safety and efficacy. [PDF]

PLoS ONE, 2009
BACKGROUND:Several anti-viral drugs have demonstrated efficacy in preventing Cytomegalovirus (CMV) infections in solid organ transplant (SOT) patients.
Andre C Kalil, Alison G Freifeld, Elizabeth R Lyden, Julie A Stoner   +3 more
doaj   +1 more source

Evaluating EndoC βH5 pseudoislets as a model for human islet transplantation

Diabetic Medicine, EarlyView.
Abstract Aims The EndoC βH5 cell line represents a promising human β‐cell model for preclinical diabetes research. Indeed, EndoC βH5 cells aggregate into islet‐like organoids, secrete insulin in a glucose‐dependent manner, and express a variety of β‐cell functional markers.
Lydia F. Daniels Gatward, William T. Blackstone Whines, Tzu‐Wen Hong, Rosie Sullivan, Jessica Starikova, Adya Lonsane, Ryea Arora, Victoria Salem, Min Zhao, Peter M. Jones, Aileen F. J. King, Shanta J. Persaud   +11 more
wiley   +1 more source

Evaluation of Ganciclovir for Cytomegalovirus Disease

, 1989
Cytomegalovirus (CMV) infections are a common cause of morbidity and mortality in immunosuppressed patients. Ganciclovir is an acyclic deoxyguanosine analog structurally similar to acyclovir but with superior activity against CMV.
Courtney V. Fletcher, Henry H. Balfour
core   +1 more source

Eficacia del ganciclovir tópico como alternativa terapéutica de la queratitis epitelial herpética

Revista Mexicana de Oftalmología, 2014
Objetivo: Comparar el uso del ganciclovir con el del aciclovir, usados de forma tópica, para la curación de la queratitis epitelial herpética en menos de 7 días.
Carlos Álvarez-Guzmán, Alejandro Rodríguez-García, Jaime Torres-Gómez   +2 more
doaj   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Pediatric Dosing of Ganciclovir and Valganciclovir: How Model‐Based Simulations Can Prevent Underexposure and Potential Treatment Failure

CPT: Pharmacometrics & Systems Pharmacology, 2019
Intravenous ganciclovir and oral valganciclovir are effective in the prevention and treatment of pediatric cytomegalovirus (CMV) infection but various dosing regimens are used in medical practice.
Karin Jorga, Bruno Reigner, Clarisse Chavanne, Giuseppe Alvaro, Nicolas Frey   +4 more
doaj   +1 more source