Results 61 to 70 of about 28,258 (196)

The Role of Early Vitrectomy in the Healing of Retinal Lesions in Progressive Outer Retinal Necrosis

Case Reports in Ophthalmological Medicine, 2022
Purpose. To report on the efficacy of early pars plana vitrectomy (PPV), silicone oil (SO) tamponade, and intravitreal ganciclovir injection in the treatment of a case with progressive outer retinal necrosis (PORN). Case Presentation.
Hamid Riazi-Esfahani, Arash Mirzaei, Masoud Mirghorbani, Fariba Ghassemi, Mohammad Zarei, Elias Khalili Pour, Nazanin Ebrahimiadib   +6 more
doaj   +1 more source

Mechanisms of Pericyte‐Mediated Cancer Metastasis

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Pericytes play multifarious roles in promoting cancer metastasis by facilitating metastatic cancer cell dissemination, circulating tumor cell survival, tissue extravasation, premetastatic niche formation, and metastatic tumor growth. These cells have intertwined interactions with vascular endothelial cells to modulate cancer cell behavior and ...
Ziheng Guo, Yihai Cao
wiley   +1 more source

Early selection of a new UL97 mutant with a severe defect of ganciclovir phosphorylation after valaciclovir prophylaxis and short-term ganciclovir therapy in a renal transplant recipient

, 2005
International audienceWe describe the emergence of a new ganciclovir resistance mutation in the UL97 gene of human cytomegalovirus, deletion of codon 601, after valaciclovir and short-term ganciclovir therapy following kidney transplantation. Its role in
Guigonis, Vincent, Mazeron, Marie-Christine, Dehee, Axelle, Denis, François, Fillet, Anne-Marie, Champier, Gaël, Mertens, Thomas, Michel, Detlef, Bensman, Albert, Alain, Sophie, Hantz, Sébastien   +10 more
core   +1 more source

Integrating Oncolytic Virus Engineering and Delivery Strategies for Enhanced Cancer Virotherapy

Aggregate, Volume 7, Issue 6, June 2026.
Integrated engineering strategies combining oncolytic virus (OV) design with advanced delivery platforms overcome biological barriers and enhance cancer virotherapy. Genetic engineering improves viral potency and selectivity, while local and systemic delivery systems promote viral protection, tumor targeting, penetration, and tumor microenvironment ...
Jiliang Zhao, Dong Wang, Lei Wang, Hongkai Zhang, Yue Sun, Dan Ding   +5 more
wiley   +1 more source

Pediatric Dosing of Ganciclovir and Valganciclovir: How Model‐Based Simulations Can Prevent Underexposure and Potential Treatment Failure

CPT: Pharmacometrics & Systems Pharmacology, 2019
Intravenous ganciclovir and oral valganciclovir are effective in the prevention and treatment of pediatric cytomegalovirus (CMV) infection but various dosing regimens are used in medical practice.
Karin Jorga, Bruno Reigner, Clarisse Chavanne, Giuseppe Alvaro, Nicolas Frey   +4 more
doaj   +1 more source

Pharmacokinetics of Ganciclovir after Oral Valganciclovir versus Intravenous Ganciclovir in Allogeneic Stem Cell Transplant Patients with Graft-versus-Host Disease of the Gastrointestinal Tract

, 2006
The pharmacokinetics of ganciclovir after oral valganciclovir versus intravenous ganciclovir were compared in allogeneic stem cell transplant recipients with stable graft-versus-host disease of the gastrointestinal tract.
Gabriel, Don A., Ratanatharathorn, Voravit, Winston, Drew J., Emmanouilides, Christos, Shaw, Leslie M., Baden, Lindsey R., Lange, W. Robert   +6 more
core   +1 more source

Preemptive ganciclovir for mechanically ventilated patients with cytomegalovirus reactivation

, 2021
International audienceBackground: The effect of cytomegalovirus (CMV) reactivation on the length of mechanical ventilation and mortality in immunocompetent ICU patients requiring invasive mechanical ventilation remains controversial.
Jean Chastre, Toufik Kamel, Allardet-Servent, Jérôme, Lu, Qin, Laurent Papazian, Jung, Boris, Nadia Aissaoui, Bourenne, Jérémy, Jaber, Samir, Schwebel, Carole, Anderson Loundou, Leone, Marc, Penot-Ragon, Christine, Zandotti, Christine, Sophie Cayot-Constantin, Cayot-Constantin, Sophie, Loundou, Anderson, Jérôme Allardet-Servent, Qin Lu, Charles-Edouard Luyt, Forel, Jean-Marie, Karine Baumstarck, Boris Jung, Luyt, Charles-Edouard, Christine Zandotti, Souweine, Bertrand, Hraiech, Sami, Sami Hraiech, Kamel, Toufik, Papazian, Laurent, Baumstarck, Karine, Christine Penot-Ragon, Aissaoui, Nadia, Chastre, Jean, Carole Schwebel, Jean-Marie Forel, Samir Jaber, Jérémy Bourenne, Marc Leone, Bertrand Souweine   +39 more
core   +1 more source

In Vitro Treatment with Ganciclovir Restores the Functionality of Exhausted T Cells from Cancer Patients

International Journal of Gerontology, 2013
Background: Human cytomegalovirus (CMV) is a lifelong, often asymptomatic infection, with the virus maintained in latently infected myeloid cells. Patients receiving chemotherapy for cancer are at high risk of reactivation of latent CMV, which may ...
Chia-Ming Chang, Chien-Liang Wu, I-Hsuan Chen, Kate Hsu, Hsin-Tsung Ho, I-Pin Chuang, Yen-Ta Lu   +6 more
doaj   +1 more source

Rezidivprophylaxe der Zytomegalievirus-Uveitis mit topischem Ganciclovir

, 2019
PURPOSE ytomegalovirus (CMV) can cause recurrent or chronic hypertensive anterior uveitis in immunocompetent patients. Antiviral treatment options include topical ganciclovir or systemic valganciclovir.
Hänsli, Christof, Meier, Fabio, Barthelmes, Daniel, Böni, Christian   +3 more
core   +1 more source

European Recommendations for Transitioning the Care of Patients With Multiple Myeloma Treated With B‐Cell Maturation Antigen Bispecific Antibodies From Academic Hospitals to Community‐Based Centers and for Outpatient Step‐Up Dosing

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Introduction Safe outpatient delivery of B‐cell maturation antigen–targeting bispecific antibodies (BCMA‐BsAbs) in multiple myeloma (MM) is challenging, particularly during step‐up dosing (SUD). Standardized guidance for European community practice is limited.
María‐Victoria Mateos, Elena Zamagni, Massimo Gentile, Rachel Hall, Florence Lachenal, Mónica López Riñon, Rakesh Popat, Christof Scheid, Thomas Wolff, Isabel Perez‐Cruz, Mohamad Mohty   +10 more
wiley   +1 more source