Results 51 to 60 of about 24,759 (160)

Treatment Outcomes of Hospitalized Patients With Inflammatory Bowel Disease at a Tertiary Care Center in Nepal: A Cross‐Sectional Study

JCC Plus, Volume 1, Issue 4, July 2026.
Overall, patients with IBD constituted 1.6% (n = 37) of all admissions to the gastroenterology ward for any indication. Most (2/3rd) hospitalized patients with IBD responded to conventional therapy; one third required advanced therapy or surgery. In‐hospital mortality was high at 5%, probably related to delayed diagnosis, limited access to advanced ...
Ajay Kumar Yadav, Bhupendra Kumar Basnet, Ramila Shrestha, Ajit Khanal, Milan Shrestha, Mukesh Sharma Poudel   +5 more
wiley   +1 more source

Surveillance of CMV Terminase Gene Mutations in Allogeneic Hematopoietic Stem Cell Transplant Recipients Receiving Letermovir Prophylaxis

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT Letermovir (LMV), a CMV‐specific terminase inhibitor, is recommended for cytomegalovirus (CMV) prophylaxis in CMV‐seropositive allogeneic hematopoietic stem cell transplant (alloHSCT) recipients. The association between low‐level CMV DNAemia during prophylaxis and the emergence of mutations in CMV terminase complex genes remains unclear.
Amandine Caillault, Alienor Xhaard, Severine Mercier‐Delarue, Linda Feghoul, Julien Robert, Nathalie Schnepf, David Michonneau, Marie Robin, Flore Sicre de Fontbrune, Eleonore Kaphan, Mathilde Ruggiu‐Goiran, Pedro Henrique de Lima Prata, Florian Chevillon, Matthieu Jestin, Nathalie Dhedin, Gerard Socie, Régis Peffault de Latour, Maud Salmona, Jérôme LeGoff   +18 more
wiley   +1 more source

Model Ensembling and Machine Learning Approaches to Predict the First Dose of Amoxicillin in Intensive Care

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
ABSTRACT A priori model‐informed precision dosing (MIPD) recommends an appropriate first dose based solely on the patient's covariates enabling faster target attainment without required concentration measurements. Population pharmacokinetic (PopPK) model ensembling and machine learning (ML) approaches were developed and evaluated to predict a first ...
Mihály Leiwolf, Nicolas Gregoire, Sophie Magréault, Bénédicte Franck, Ombeline Krekounian, Jean‐Baptiste Woillard, Vincent Aranzana‐Climent   +6 more
wiley   +1 more source

Cytomegalovirus and Inflammatory Bowel Diseases (IBD) with a Special Focus on the Link with Ulcerative Colitis (UC)

Microorganisms, 2020
Cytomegalovirus (CMV) infects approximately 40% of adults in France and persists lifelong as a latent agent in different organs, including gut. A close relationship is observed between inflammation that favors viral expression and viral replication that ...
Alexandre Jentzer, Pauline Veyrard, Xavier Roblin, Pierre Saint-Sardos, Nicolas Rochereau, Stéphane Paul, Thomas Bourlet, Bruno Pozzetto, Sylvie Pillet   +8 more
doaj   +1 more source

Advances in Polyethyleneimine‐Derived Nanoformulations

Small Science, Volume 6, Issue 7, July 2026.
This article illustrates the cytotoxic effects of polyethyleneimine (PEI) on cell membranes and mitochondria, the strategies employed to mitigate PEI‐associated toxicity through chemical modification, PEGylation, and structural optimization, and the major types of PEI‐based formulations developed for the delivery of therapeutic drugs, nucleic acids ...
Mohamed S. Attia, Mariusz Skwarczynski, Waleed M. Hussein   +2 more
wiley   +1 more source

Does Cytomegalovirus Develop Resistance following Antiviral Prophylaxis and Treatment in Renal Transplant Patients in Kuwait?

Advances in Virology, 2011
The resistance of cytomegalovirus (CMV) to ganciclovir or valganciclovir is a factor in therapeutic failure and disease progression. CMV strains resistant to ganciclovir or valganciclovir have been associated with specific mutations in the UL97 and UL54 ...
Nada Madi, Widad Al-Nakib, Alexander Pacsa   +2 more
doaj   +1 more source

Topical ganciclovir in the treatment of acute herpetic keratitis

Clinical Ophthalmology, 2010
Khalid F Tabbara1,2,3, Noorjehan Al Balushi11The Eye Center and The Eye Foundation for Research in Ophthalmology, Riyadh, 2Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; 3The Wilmer ...
Khalid F Tabbara, Noorjehan Al Balushi
doaj  

Crystallization after intravitreal ganciclovir injection

Clinical Ophthalmology, 2010
Pitipol Choopong, Nattaporn Tesavibul, Nattawut RodanantDepartment of Ophthalmology, Siriraj Hospital, Mahidol University, Bangkok, ThailandPurpose: To report crystal formation as a complication of intravitreal ganciclovir injection.Patients and methods:
Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant   +2 more
doaj  

Ganciclovir use evaluation in kidney transplantation departments

Journal of Research in Pharmacy Practice, 2016
Objective: In this study, we evaluated certain aspects of the usage and administration of one lifesaving, high-cost medication, i.e., Ganciclovir for the prevention and treatment of cytomegalovirus (CMV) infection in transplant patients.
Maryam Mozaffar, Shahrzad Shahidi, Shirinsadat Badri   +2 more
doaj   +1 more source

Foscarnet Versus Ganciclovir for Severe Congenital Cytomegalovirus Infection: Short- and Long-Term Follow-Up

Viruses
Background: Cytomegalovirus (CMV) infection is the most common and serious congenital infection, with universal screening in pregnancy, standardized therapy, and a vaccine still lacking.
Giovanni Nigro, Marta Buzzi, Milena Catenaro, Eleonora Coclite, Mario Muselli   +4 more
doaj   +1 more source