Results 31 to 40 of about 30,075 (198)

Dasatinib and quercetin prevent alveolar bone loss in aged mice

Journal of Periodontology, EarlyView.
Abstract Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro‐inflammatory environment which may exacerbate tissue damage.
Luisa S. Battistelli, Renata M. Moraes, Yuri C. Santos, Jaqueline L. Ribeiro, Maíra T. Garcia, Renata F. Prado, Florent Elefteriou, Ana Lia Anbinder   +7 more
wiley   +1 more source

Reversion of Val(Ganciclovir)-Resistance-Associated Mutations in Two SOT Patients with Mismatched Serostatus for CMV (D+/R-)

Viruses
The emergence of drug-resistant cytomegalovirus (CMV) complicates viral response to therapy. We present two cases of solid organ transplant (SOT) recipients, highlighting the reversion of UL97 mutations associated with val(ganciclovir) resistance ...
Elena Seminari, Alessandra Tebaldi, Aurelia Sangani, Paola Giordani, Daniele Lilleri, Stefania Paolucci, Giulia Campanini, Elizabeth Iskandar, Fausto Baldanti, Raffaele Bruno   +9 more
doaj   +1 more source

Impact of antiviral treatment on long-term prognosis in non-immunocompromised patients with CMV reactivation

BMC Infectious Diseases, 2021
Background Reactivation of human cytomegalovirus (CMV) occurs in non-immunocompromised patients with or without specific organ involvement, but it is still unknown whether it has a clinical implication on long-term prognosis or not.
Ga Eun Park, Hyun Kyun Ki, Jae-Hoon Ko
doaj   +1 more source

Treatment of Congenital Cytomegalovirus Beyond the Neonatal Period: A Single‐Arm Meta‐Analysis

The Laryngoscope, EarlyView.
This systematic review and single‐arm meta‐analysis evaluated hearing outcomes following antiviral therapy initiated after the neonatal period in children with congenital cytomegalovirus infection. Across eight studies including 192 patients, post‐neonatal treatment was associated with meaningful hearing improvement and low rates of hearing ...
Thamiris D. D. Cabral, Marcela Mafra, Jaime Plane, Matheus Sewastjanow‐Silva, Isadora Martins Nascimento, Asitha D. L. Jayawardena, Abby Meyer, Andrew Redmann, Luke Jakubowski   +8 more
wiley   +1 more source

Ganciclovir

, 2006
europepmc   +3 more sources

Development and Validation of Valganciclovir and its Active Metabolite Ganciclovir Determination in Human Plasma by HPLC-UV Method

Разработка и регистрация лекарственных средств, 2020
Introduction. Viral infections are a serious problem that occurs during the use of immunosuppressants in preparation for organ transplantation and in the postoperative period.
T. N. Komarov, I. E. Shohin, O. A. Miskiv, D. S. Bogdanova, A. V. Aleshina, Yu. V. Medvedev, N. S. Bagaeva   +6 more
doaj   +1 more source

Long‐term outcomes of haploidentical hematopoietic stem cell transplantation with antithymocyte globulin–based myeloablative conditioning in pediatric refractory or relapsed non‐Hodgkin lymphoma

Pediatric Investigation, EarlyView.
Single‐center retrospective data showed that ATG‐based myeloablative haploidentical hematopoietic stem cell transplantation provides durable remission and favorable long‐term survival in children with refractory/relapsed non‐Hodgkin lymphoma, achieving high engraftment rates, low relapse incidence, and acceptable toxicity.
Chenguang Jia, Jie Zheng, Meng Yuan, Hongbo He, Yibo Fan, Bin Wang, Guanghua Zhu, Jun Yang, Yanhui Luo, Lixiao Cai, Pan Zhang, Yanlong Duan, Maoquan Qin   +12 more
wiley   +1 more source

Initial intravitreal injection of high-dose ganciclovir for cytomegalovirus retinitis in HIV-negative patients

BMC Ophthalmology, 2018
Background The purpose of this study is to examine the clinical outcomes achieved by using initial high-dose intravitreal ganciclovir injections to treat cytomegalovirus retinitis in patients without human immunodeficiency virus (HIV) infection.
Zhuyun Qian, Haili Li, Yong Tao, Wensheng Li   +3 more
doaj   +1 more source

High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution [PDF]

, 2002
Nonmyeloablative conditioning is increasingly used for transplantation in a wide range of diseases, but little is known about its impact on the incidence of infections and immune reconstitution.
Mahendra, P, Marshall, T, O'Gorman, P, Osman, H., Chakraverty, R, Hale, G., Osman, H, Peggs, K., O'Gorman, P., Mahendra, Premini, Mackinnon, S, Fegan, Christopher, Chopra, Ravinder, Linch, DC, Goldstone, A.H., Chopra, R, Waldmann, H., Milligan, D.W., Chakrabarti, Suparno, Hale, G, Chakrabarti, S., Marshall, T., Chakrabarti, S, Peggs, K, Chakraverty, Ronjon, Chopra, R., Waldmann, H, Kottaridis, P.D., Craddock, C., Milligan, DW, Mackinnon, S., Chakraverty, R., Kottaridis, PD, Yong, K., Kottaridis, P, Milligan, Donald, Mahendra, P., Craddock, Charles; id_orcid, Craddock, C, Yong, K, Goldstone, AH, Waldmann, Herman, Fegan, CD, Fegan, C.D., Linch, D.C.   +44 more
core   +1 more source

Standard ganciclovir dosing results in slow decline of cytomegalovirus viral loads [PDF]

, 2021
BACKGROUND: Cytomegalovirus (CMV) can cause severe disease, including rejection in transplant recipients. Ganciclovir and its oral prodrug valganciclovir have been used as first-line therapy for CMV disease in transplant recipients.
Knoester, Marjolein, Consortium, GATEWAY-1 Study, Alffenaar, Jan-Willem C, Hope, William, Märtson, Anne-Grete, Sturkenboom, Marieke G G; id_orcid, Märtson, Anne-Grete; id_orcid, Sturkenboom, Marieke GG, van der Werf, Tjip S, Sturkenboom, Marieke G G   +9 more
core   +2 more sources