Results 61 to 70 of about 44,210 (231)

Targeting Genome Maintenance Defects of Cancers Using Chain‐Terminating Nucleoside Analogs

Cancer Science, EarlyView.
Nucleoside analogs interfere with DNA replication either by their chain‐terminating properties or by serving as DNA damage on the template. The genome maintenance pathways required to maintain cellular tolerance to each nucleoside analog vary depending on the drug.
Ryotaro Kawasumi, Rubaiat E. Tabassum, Kouji Hirota   +2 more
wiley   +1 more source

Long-Term Outcome of Treatment with 2% Topical Ganciclovir Solution in Cytomegalovirus Anterior Uveitis and Corneal Endotheliitis

Infection and Drug Resistance, 2022
Po-Jui Chen,1 I-Huang Lin,1 Yi-Chun Chi,2 Chun-Chieh Lai,1 Jia-Horung Hung,1 Sung-Huei Tseng,1 Yi-Hsun Huang1 1Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan ...
Chen PJ, Lin IH, Chi YC, Lai CC, Hung JH, Tseng SH, Huang YH   +6 more
doaj  

Eficacia del ganciclovir tópico como alternativa terapéutica de la queratitis epitelial herpética

Revista Mexicana de Oftalmología, 2014
Objetivo: Comparar el uso del ganciclovir con el del aciclovir, usados de forma tópica, para la curación de la queratitis epitelial herpética en menos de 7 días.
Carlos Álvarez-Guzmán, Alejandro Rodríguez-García, Jaime Torres-Gómez   +2 more
doaj   +1 more source

Cytomegalovirus mismatch after heart transplantation: Impact of antiviral prophylaxis and intravenous hyperimmune globulin

Immunity, Inflammation and Disease, 2021
Objective Cytomegalovirus (CMV) infections are correlated with complications following heart transplantation (HTx) and impaired outcome. The impact of a serologic mismatch between donor and recipient and the necessity of prophylactic virostatic ...
Moritz B. Immohr, Payam Akhyari, Charlotte Böttger, Arash Mehdiani, Hannan Dalyanoglu, Ralf Westenfeld, Daniel Oehler, Igor Tudorache, Hug Aubin, Artur Lichtenberg, Udo Boeken   +10 more
doaj   +1 more source

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, EarlyView.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

Pediatric Dosing of Ganciclovir and Valganciclovir: How Model‐Based Simulations Can Prevent Underexposure and Potential Treatment Failure

CPT: Pharmacometrics & Systems Pharmacology, 2019
Intravenous ganciclovir and oral valganciclovir are effective in the prevention and treatment of pediatric cytomegalovirus (CMV) infection but various dosing regimens are used in medical practice.
Karin Jorga, Bruno Reigner, Clarisse Chavanne, Giuseppe Alvaro, Nicolas Frey   +4 more
doaj   +1 more source

Alemtuzumab induction and tacrolimus monotherapy in pancreas transplantation: One- and two-year outcomes [PDF]

, 2006
BACKGROUND. Alemtuzumab (Campath-1H) induction with tacrolimus monotherapy has been shown to provide effective immunosuppression for kidney, liver, lung, and small bowel transplantation.
Abu-Elmagd, Akhtar Khan, Amadeo Marcos, Amit Basu, Calne, Ciano, Deanna Blisard, Flechner, Gruessner, Hale, Henkie P. Tan, John J. Fung, Kaufmann, Kirk, Knechtle, Knechtle, Kusum Tom, Marcos, Marcos, McCurry, Ngoc L. Thai, Ron Shapiro, Shapiro, Shapiro, Starzl, Starzl, Starzl, Starzl, Stuart, Thai, Thomas E. Starzl, Tryphonopoulos, Tzakis, Watson   +33 more
core   +1 more source

Characteristics of Acyclovir‐Resistant Herpes Simplex Virus Infection in Hematological Patients

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Objective Acyclovir‐resistant herpes simplex virus infections pose a significant challenge in immunosuppressed patients. This study aimed to characterize the clinical features, treatment outcomes, and mortality associated with acyclovir‐resistant herpes simplex virus infection. Materials and Methods A retrospective analysis was conducted on 18
Reema Shehadeh, Mor Bar Ilan, Sara Dovrat, Ronit Yerushalmi, Michal Tepperberg Oikawa, Evangelia Piperi, Nikolaos G. Nikitakis, Noam Yarom   +7 more
wiley   +1 more source

In Vitro Treatment with Ganciclovir Restores the Functionality of Exhausted T Cells from Cancer Patients

International Journal of Gerontology, 2013
Background: Human cytomegalovirus (CMV) is a lifelong, often asymptomatic infection, with the virus maintained in latently infected myeloid cells. Patients receiving chemotherapy for cancer are at high risk of reactivation of latent CMV, which may ...
Chia-Ming Chang, Chien-Liang Wu, I-Hsuan Chen, Kate Hsu, Hsin-Tsung Ho, I-Pin Chuang, Yen-Ta Lu   +6 more
doaj   +1 more source

A Matched Case‐Control Study to Evaluate Predicted Drug Exposures and Neutropenia during Valganciclovir Prophylaxis in Pediatric Solid Organ Transplant Recipients

Transplant Infectious Disease, EarlyView.
In this retrospective case‐control study, among 35 case‐control matches, no differences were identified in predicted plasma ganciclovir AUCs between pediatric solid organ transplant (SOT) recipients prescribed valganciclovir with and without neutropenia.
Mai‐Uyen T. Nguyen, Michael N. Neely, Anders Åsberg, Craig L. K. Boge, Kevin J. Downes   +4 more
wiley   +1 more source