Results 111 to 120 of about 79,768 (305)

Chemoenzymatically Synthesized O‐Acetylated GD3 Gangliosides to Examine Viral Receptor Specificities in a Cellular Context

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
7‐O‐, 9‐O‐, and 7,9‐di‐O‐acetylated GD3 gangliosides can be prepared by chemical assembly of a tetrasaccharide as α‐glycosyl fluoride that is coupled to sphingosine using a glycosynthase, followed by O‐acetyl editing by coronaviral hemagglutinin‐esterases (HEs).
Zhiyong Zhang, Ruonan Liang, Kevin C. Hooijschuur, Robert P. de Vries, Zeshi Li, Geert‐Jan Boons   +5 more
wiley   +2 more sources

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source

On why cancer cells require a great amount of glucose

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract The traditional thinking has been that cancer cells require a great amount of glucose to support their rapid growth, but the reality may be different. We have previously demonstrated that all cancer cells in The Cancer Genome Atlas harbor persistent Fenton reactions in their cytosol, which generate OH− ${\text{OH}}^{-}$ and ultimately kill the
Xuechen Mu, Aoran Liu, Rui Shi, Long Xu, Zhenyu Huang, Ye Zhang, Ying Xu   +6 more
wiley   +1 more source

Isolation and characterization of ganglioside GM1b from normal human brain.

Journal of Lipid Research, 1987
A sialidase-susceptible monosialoganglioside was isolated from normal human brain by DEAE-Sephadex A-25 and Iatrobeads column chromatography. The yield of this ganglioside was about 6 mg per whole brain.
T Ariga, R K Yu
doaj   +1 more source

Sialylation patterns in cerebral amyloid angiopathy

Brain Pathology, Volume 36, Issue 2, March 2026.
This study is the first to localize and evaluate sialylation modifications in the context of Alzheimer's Disease and Cerebral Amyloid Angiopathy, revealing a unique disease‐specific increase in intravascular sialylation. Abstract Glycosylation is the most common form of post‐translational modification in the brain and becomes significantly altered in ...
Caitlyn Fastenau, Rebecca Crisp, Mallory Keating, Elizabeth Ochoa, Timothy E. Richardson, Margaret E. Flanagan, Jamie M. Walker, Sarah C. Hopp, Kevin F. Bieniek   +8 more
wiley   +1 more source

Cell Propagation of Cholera Toxin CTA ADP-Ribosylating Factor by Exosome Mediated Transfer [PDF]

, 2018
In this study, we report how the cholera toxin (CT) A subunit (CTA), the enzyme moiety responsible for signaling alteration in host cells, enters the exosomal pathway, secretes extracellularly, transmits itself to a cell population.
Boussadia, Zaira, Carollo, Maria, Fabbri, Alessia, Falchi, Mario, Fecchi, Katia, Fiani, Maria Luisa, Gallina, Angelo, Palermo, Angela, Parisi, Sofia, Pasquini, Luca, Sargiacomo, Massimo, Zanetti, Cristiana   +11 more
core   +1 more source

The Phospholipid Bis(monoacylglycero)Phosphate Confers Antitumour Immunogenicity to Exosomes Secreted by Dendrogenin A, Which Activates Its Biosynthesis in Tumour Cells

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
Dendrogenin A stimulates, via LXRβ, the expression and activity of enzymes responsible for the biosynthesis of the phospholipid BMP. BMP is a key determinant of the antitumour immunogenicity of exosomes secreted by DDA‐treated melanoma and triple‐negative breast cancer cells and enhances mouse survival and anti‐PD‐1 therapy in melanoma.
Julio Buñay, Michel Record, Philippe de Medina, Silia Ayadi, Laly Pucheu, Céline Colacios, Bruno Ségui, Marcus Höring, Gerhard Liebisch, Hélène Martin, Marc Poirot, Sandrine Silvente‐Poirot   +11 more
wiley   +1 more source

Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease--a review.

Journal of Lipid Research, 2008
Gangliosides are expressed in the outer leaflet of the plasma membrane of the cells of all vertebrates and are particularly abundant in the nervous system. Ganglioside metabolism is closely associated with the pathology of Alzheimer's disease (AD).

semanticscholar   +1 more source

Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence [PDF]

, 2021
Dragana Fabris, Ivana Karmelić, Hasan Muharemović, Tomislav Sajko, Mia Jurilj, Slavica Potočki, Ruđer Novak, Željka Vukelić   +7 more
openalex   +1 more source

Antibody‐Targeted Artificial T Cell and Natural Killer Cell Derived Vesicles for Cancer Immunotherapy

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
ABSTRACT T cell and NK92 cell‐derived extracellular vesicles or artificial cell‐derived vesicles (ACDVs) exhibit anti‐cancer effects through inherited cytotoxic proteins like perforin and granzyme or transmembrane receptors like FasL and TRAIL. The anti‐cancer potential of artificial T and NK vesicles has been improved by attaching targeting moieties ...
Brijesh Parlekar, David W. Livingstone, Ashley R. Sutherland, Andrés X. Medina, Wendy Bernhard, John DeCoteau, Tays Hernández, Clarence Ronald Geyer   +7 more
wiley   +1 more source