Results 41 to 50 of about 79,768 (305)
PS Dependent APP Cleavage Regulates Glucosylceramide Synthase and is Affected in Alzheimer's Disease
Cellular Physiology and Biochemistry, 2014 Background: Gangliosides were found to be associated with Alzheimer's disease (AD). Here we addressed a potential function of γ-secretase (presenilin) dependent cleavage of the amyloid-precursor-protein (APP) in the regulation of ganglioside de novo
Marcus O.W. Grimm +15 more
doaj +1 more source
Co-cultures with stem cell-derived human sensory neurons reveal regulators of peripheral myelination [PDF]
, 2017 Effective bidirectional signalling between axons and Schwann cells is essential for both the development and maintenance of peripheral nerve function. We have established conditions by which human induced pluripotent stem cell-derived sensory neurons can
Bennett, David L.H. +5 more
core +2 more sources
Landmark-Based Registration of Curves via the Continuous Wavelet Transform [PDF]
, 2006 This paper is concerned with the problem of the alignment of multiple sets of curves. We analyze two real examples arising from the biomedical area for which we need to test whether there are any statistically significant differences between two subsets ...
Bigot, Jérémie
core +4 more sources
Anti-Ganglioside Antibodies Induce Nodal and Axonal Injury via Fcγ Receptor-Mediated Inflammation
Journal of Neuroscience, 2015 Guillain-Barré syndrome (GBS) is a postinfectious autoimmune neuropathy and anti-ganglioside antibodies (Abs) are strongly associated with this disorder.
Lan He +4 more
semanticscholar +1 more source
Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies [PDF]
, 1993 The first human monoclonal islet cell antibodies of the IgG class (MICA 1-6) obtained from an individual with Type 1 (insulin-dependent) diabetes mellitus were cytoplasmic islet cell antibodies selected by the indirect immunofluorescence test on pancreas
DJ Garry +19 more
core +1 more source
Regulation of ganglioside biosynthesis in the nervous system
Journal of Lipid Research, 2004 Ganglioside biosynthesis is strictly regulated by the activities of glycosyltransferases and is necessarily controlled at the levels of gene transcription and posttranslational modification.
Robert K. Yu +3 more
doaj +1 more source
Cancer Medicine, 2023 Background While chimeric antigen receptor (CAR)‐T cell therapy has demonstrated excellent efficacy in hematopoietic malignancies, its clinical application in solid cancers has yet to be achieved.
Takahiro Sasaki +4 more
doaj +1 more source
Journal of Hematology & Oncology, 2018 Background Chimeric antigen receptor (CAR)-engineered T cells have demonstrated promising clinical efficacy in patients with B cell lymphoma. However, the application of CAR-T cell therapy in the treatment of other solid tumors has been limited.
Jiayi Yu +13 more
doaj +1 more source
Differential binding patterns of anti-sulfatide antibodies to glial membranes [PDF]
, 2018 Sulfatide is a major glycosphingolipid in myelin and a target for autoantibodies in autoimmune neuropathies. However neuropathy disease models have not been widely established, in part because currently available monoclonal antibodies to sulfatide may ...
Barrie, Jennifer A. +8 more
core +1 more source
Gangliosides and the Treatment of Neurodegenerative Diseases: A Long Italian Tradition
Biomedicines, 2022 Gangliosides are glycosphingolipids which are particularly abundant in the plasma membrane of mammalian neurons. The knowledge of their presence in the human brain dates back to the end of 19th century, but their structure was determined much later, in ...
Maria Fazzari +4 more
doaj +1 more source