Results 51 to 60 of about 21,456 (123)

Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders

MedComm, Volume 7, Issue 4, April 2026.
CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley   +1 more source

From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans [PDF]

, 2009
Glycan epitopes of cellular glycoconjugates act as versatile biochemical signals (sugar coding). Here, we test the hypothesis that the common N-glycan modifications by core fucosylation and introduction of the bisecting N-acetylglucosamine moiety have ...
André, Sabine, Gabius, Hans-Joachim, Kojima, Shuji, Kozar, Tibor, Unverzagt, Carlo   +4 more
core   +1 more source

Pyridostigmine Treatment for Pediatric Axonal Guillain–Barré Syndrome

Muscle &Nerve, Volume 73, Issue 4, Page 655-662, April 2026.
ABSTRACT Introduction/Aims Direct involvement of the neuromuscular junction (NMJ) in the inflammatory process of Guillain–Barré syndrome (GBS) has been described. Despite this, the NMJ very rarely serves as a target for direct medical intervention in GBS.
E. Zohar‐Dayan, J. Landa, S. Barak, B. Ben‐Zeev   +3 more
wiley   +1 more source

Exosomes promote pre-metastatic niche formation in ovarian cancer. [PDF]

, 2019
Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic growth occurs in stages, with the formation of a
Dean, Dylan C, Duan, Zhenfeng, Feng, Wenlong, Hornicek, Francis J, Shi, Huirong   +4 more
core   +2 more sources

Toxic mechanisms of amyloid oligomers and therapeutic strategies

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

Advances in the diagnosis, immunopathogenesis and therapies of IgM-anti-MAG antibody-mediated neuropathies. [PDF]

, 2018
Polyneuropathy with immunoglobulin M (IgM) monoclonal gammopathy is the most common paraproteinemic neuropathy, comprising a clinicopathologically and immunologically distinct entity.
Dalakas, Marinos
core   +2 more sources

In vitro, cellular and in vivo studies of amyloid oligomers structure and toxicity: Challenges and advances

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Oligomeric assemblies of amyloidogenic proteins, such as Aβ, tau, α‐synuclein, amylin, transthyretin, and TDP‐43, are increasingly recognized as key drivers of cellular dysfunction across a range of neurodegenerative and systemic disorders.
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

Role of mitochondrial raft-like microdomains in the regulation of cell apoptosis [PDF]

, 2015
Lipid rafts are envisaged as lateral assemblies of specific lipids and proteins that dissociate and associate rapidly and form functional clusters in cell membranes.
A Al-Saif, A Bertoni, A Cossarizza, A Ferri, A Israelson, A Raturi, A Valencia, A Valencia, AA Rowland, AE Rusinol, AL Nishimura, AL Wozniak, Alberto Ferri, AM Giammarioli, AO Hueber, B Kornmann, C Barbat, C Brooks, C Dall’Armi, C Frezza, C Gajate, C Garcia-Ruiz, C Garcia-Ruiz, C Martel, C Steinmann, C Vande Velde, CB Pickett, CD Austin, CH Chou, CL Schengrund, D Naon, D Scheel-Toellner, D Scheel-Toellner, DF Legler, DF Suen, DT Browman, E Bossy-Wetzel, E Lai, E Szegezdi, EM Lynes, EM Lynes, F Korobova, F Mollinedo, G Csordas, G Szabadkai, GC Shore, GM Cereghetti, H Grassmè, H Yano, I Annunziata, I Poggiolini, J Faitova, J Katz, J Stiban, JC Martinou, JC Wanson, JE Vance, JL Herrera, JR Friedman, JT Vollrath, K Banki, K Simons, K Simons, KF Ferri, KR Pitts, L Ciarlo, L Ciarlo, L Dupuis, L Scorrano, LA Lewis, M Cozzolino, M Cozzolino, M Degli Esposti, M Degli Esposti, M Fujimoto, M Hamasaki, M Hamasaki, M Karbowski, M Lutter, M Satoh, M Sorice, M Sorice, M Sorice, M Sorice, M Sorice, M Vey, Maria Grasso, Maurizio Sorice, ME Soriano, MG Martín, MM Young, MR Rippo, MT Dimanche-Boitre, N Myhill, N Naslavsky, N Zurgil, NT Watt, OM Brito de, OM Brito de, P Matarrese, P Matarrese, P Matarrese, P Pizzo, P Pizzo, P Pizzo, PA Parone, PJ Meier, R Rizzuto, R Rizzuto, R Sano, R Stoica, RG Burns, RM Siegel, Roberta Misasi, S Ayala-Peña, S Cipolat, S Eda, S Hoppins, S Montessuit, S Orrenius, S Ouasti, S Sonnino, SB Prusiner, SW Ahn, SY Gilady, T Garofalo, T Garofalo, T Gutierrez, T Hayashi, T Hayashi, T Hayashi, T Hayashi, T Kuwana, T Simmen, T Simmen, Tina Garofalo, UP Shirendeb, V Lallemand-Breitenbach, V Mattei, V Mattei, V Mattei, Valeria Manganelli, Vincenzo Mattei, W Hu, W Malorni, W Song, W Song, X Guo, Y Higuchi, Y Yoon, Y Zhang, YJ Lee, Z Sui, Z Wieslaw   +153 more
core   +1 more source

Targeting Cellular Lipid Rafts for Dynamic Nuclear Polarization Nuclear Magnetic Resonance

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
Illuminating lipid rafts within intact cells using dynamic nuclear polarization (DNP). Targeting lipid rafts with the protein ostreolysin A allows the selective delivery of DNP‐compatible radicals, generating hyperpolarization of nuclear spins in the lipid raft. Lipid rafts serve as important platforms for membrane and signaling proteins.
Sarah A. Overall, Agnes Eck, Ancy T. Wilson, Dorothea Pinotsi, Sina J. Hartmann, Katja Packebusch, Snorri Th. Sigurdsson, Alexander B. Barnes   +7 more
wiley   +1 more source

Investigating the interaction between the tetraspanin CD82 and gangliosides, and, The binding partners of CLEC14A and the function of the CLEC14A extracellular domain [PDF]

, 2012
Project 1: CD82 is a tetraspanin involved in tumour metastasis suppression. It is downregulated in several cancers including breast, liver and prostate cancer.
Lodhia, Puja
core