Results 41 to 50 of about 19,645 (254)
The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice [PDF]
, 2013 Gangliosides are glycosphingolipids highly enriched in neural plasma membranes, where they mediate a diverse range of functions and can act as targets for auto-antibodies present in human immune-mediated neuropathy sera.
Cunningham, Madeleine E. +4 more
core +1 more source
Molecules, 2014 A new ganglioside transformed strain isolated from soil was identified as Cellulosimicrobium sp. 21. It produced a sialidase which transformed polysialo-gangliosides GD1 and GT1 into a monosialoterahexosylganglioside, i.e., ganglioside GM1. The sialidase
Yan Zheng +7 more
doaj +1 more source
Sialic acid utilization by Cronobacter sakazakii [PDF]
, 2013 Background: The Cronobacter genus is composed of seven species, and can cause infections in all age groups. Of particular concern is C. sakazakii, as this species is strongly associated with severe and often fatal cases of necrotizing enterocolitis and ...
Forsythe, S +3 more
core +2 more sources
Molecular Genetics and Metabolism Reports, 2019 GM1 gangliosidosis is an autosomal recessive neurodegenerative disorder caused by the deficiency of lysosomal β-galactosidase (β-gal) and resulting in accumulation of GM1 ganglioside.
Yvonne L. Latour +8 more
doaj +1 more source
AAV-mediated gene delivery in adult GM1-gangliosidosis mice corrects lysosomal storage in CNS and improves survival. [PDF]
PLoS ONE, 2010 GM1-gangliosidosis is a glycosphingolipid (GSL) lysosomal storage disease caused by a genetic deficiency of acid β-galactosidase (βgal), which results in the accumulation of GM1-ganglioside and its asialo-form (GA1) primarily in the CNS.
Rena C Baek +7 more
doaj +1 more source
Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barré Syndrome in Brazil. [PDF]
, 2019 Zika virus infection is associated with the development of Guillain-Barré syndrome (GBS), a neurological autoimmune disorder caused by immune recognition of gangliosides and other components at nerve membranes.
Alcantara, Luiz Carlos Junior +7 more
core +1 more source
Anti-Inflammatory Effects of GM1 Ganglioside on Endotoxin-Induced Uveitis in Rats
Biomolecules, 2022 Exogenous ganglioside GM1 has been reported to exert an immunomodulatory effect. We investigated the anti-inflammatory effect of GM1 ganglioside on endotoxin-induced uveitis (EIU) in rats and RAW 264.7 macrophages.
Tzu-Heng Weng +2 more
doaj +1 more source
Microcavity supported lipid membranes: versatile platforms for building asymmetric lipid bilayers and for protein recognition [PDF]
, 2019 Microcavity supported lipid bilayers (MSLB) are contact-free membranes suspended across aqueousfilled pores that maintain the lipid bilayer in a highly fluidic state and free from frictional interactions with substrate.
Berselli, Guilherme +4 more
core +1 more source
Turning the spotlight on the oligosaccharide chain of GM1 ganglioside [PDF]
Glycoconjugate Journal, 2021 AbstractIt is well over a century that glycosphingolipids are matter of interest in different fields of research. The hydrophilic oligosaccharide and the lipid moiety, the ceramide, both or separately have been considered in different moments as the crucial portion of the molecule, responsible for the role played by the glycosphingolipids associated to
Chiricozzi, E. +7 more
openaire +3 more sources
Molecular Therapy: Methods & Clinical Development, 2022 GM1 gangliosidosis is a rare, inherited neurodegenerative disorder caused by mutations in the GLB1 gene, which encodes the lysosomal hydrolase acid β-galactosidase (β-gal). β-gal deficiency leads to toxic accumulation of GM1 ganglioside, predominantly in
Michaël Hocquemiller +12 more
doaj +1 more source