Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1 gangliosidosis [PDF]
Journal of Lipid Research, 2023 GM1 gangliosidosis is a neurodegenerative disorder caused by mutations in the GLB1 gene, which encodes lysosomal β-galactosidase. The enzyme deficiency blocks GM1 ganglioside catabolism, leading to accumulation of GM1 ganglioside and asialo-GM1 ...
Colleen Byrnes +2 more
exaly +4 more sources
GM1 Ganglioside Is A Key Factor in Maintaining the Mammalian Neuronal Functions Avoiding Neurodegeneration [PDF]
International Journal of Molecular Sciences, 2020 Elena Chiricozzi +2 more
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The Key Role of GM1 Ganglioside in Parkinson’s Disease [PDF]
Biomolecules, 2022 We have endeavored in this review to summarize our findings, which point to a systemic deficiency of ganglioside GM1 in Parkinson’s disease (PD) tissues.
Suman Chowdhury, Robert Ledeen
doaj +2 more sources
Anti-Inflammatory Effects of GM1 Ganglioside on Endotoxin-Induced Uveitis in Rats [PDF]
Biomolecules, 2022 Exogenous ganglioside GM1 has been reported to exert an immunomodulatory effect. We investigated the anti-inflammatory effect of GM1 ganglioside on endotoxin-induced uveitis (EIU) in rats and RAW 264.7 macrophages.
Tzu-Heng Weng +2 more
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Advanced Science, 2023 A hallmark of Alzheimer's disease (AD) is the senile plaque, which contains β‐amyloid peptides (Aβ). Ganglioside GM1 is the most common brain ganglioside. However, the mechanism of GM1 in modulating Aβ processing is rarely known.
Xiaotong Wang +2 more
exaly +2 more sources
Human GLB1 knockout cerebral organoids: A model system for testing AAV9-mediated GLB1 gene therapy for reducing GM1 ganglioside storage in GM1 gangliosidosis [PDF]
Molecular Genetics and Metabolism Reports, 2019 GM1 gangliosidosis is an autosomal recessive neurodegenerative disorder caused by the deficiency of lysosomal β-galactosidase (β-gal) and resulting in accumulation of GM1 ganglioside.
Yvonne L. Latour +8 more
doaj +2 more sources
Pathophysiology of Ganglioside GM1 in Ischemic Stroke: Ganglioside GM1: A Critical Review
Cell Transplantation, 2019 Ganglioside GM1 is a member of the ganglioside family which has been used in many countries and is thought of as a promising alternative treatment for preventing several neurological diseases, including cerebral ischemic injury.
Wenchao Zhang +2 more
exaly +2 more sources
Cholesterol accelerates the binding of Alzheimer’s beta-amyloid peptide to ganglioside GM1 through a universal hydrogen-bond-dependent sterol tuning of glycolipid conformation. [PDF]
Frontiers in Physiology, 2013 Age-related alterations of membrane lipids in brain cell membranes together with high blood cholesterol are considered as major risk factors for Alzheimer’s disease. Yet the molecular mechanisms by which these factors increase Alzheimer’s risk are mostly
Jacques eFantini +2 more
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Clinics, 2022 Objectives: To evaluate the functional and immunohistochemical effects of ganglioside GM1 and erythropoietin following experimental spinal cord injury. Methods: Thirty-two male BALB/c mice were subjected to experimental spinal cord injury using the NYU ...
Alessandro Gonzalez Torelli +6 more
doaj +2 more sources
GM1 Ganglioside Promotes Osteogenic Differentiation of Human Tendon Stem Cells [PDF]
Stem Cells International, 2018 Gangliosides, the sialic acid-conjugated glycosphingolipids present in the lipid rafts, have been recognized as important regulators of cell proliferation, migration, and apoptosis.
Sonia Bergante +11 more
doaj +2 more sources