GM1 and GM2 gangliosides: recent developments
Biomolecular Concepts, 2014 GM1 and GM2 gangliosides are important components of the cell membrane and play an integral role in cell signaling and metabolism. In this conceptual overview, we discuss recent developments in our understanding of the basic biological functions of GM1 ...
Bisel Blaine +2 more
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Identification of GM1-Ganglioside Secondary Accumulation in Fibroblasts from Neuropathic Gaucher Patients and Effect of a Trivalent Trihydroxypiperidine Iminosugar Compound on Its Storage Reduction [PDF]
MoleculesGaucher disease (GD) is a rare genetic metabolic disorder characterized by a dysfunction of the lysosomal glycoside hydrolase glucocerebrosidase (GCase) due to mutations in the gene GBA1, leading to the cellular accumulation of glucosylceramide (GlcCer).
Costanza Ceni +10 more
doaj +2 more sources
Interaction between Simian Virus 40 Major Capsid Protein VP1 and Cell Surface Ganglioside GM1 Triggers Vacuole Formation [PDF]
mBio, 2016 Simian virus 40 (SV40), a polyomavirus that has served as an important model to understand many aspects of biology, induces dramatic cytoplasmic vacuolization late during productive infection of monkey host cells.
Yong Luo +5 more
doaj +2 more sources
Piezo1 Is Required for Myoblast Migration and Involves Polarized Clustering in Association with Cholesterol and GM1 Ganglioside. [PDF]
Cells, 2023 Vanderroost J +7 more
europepmc +3 more sources
Ganglioside GM1 and the Central Nervous System [PDF]
International Journal of Molecular Sciences, 2023 GM1 is one of the major glycosphingolipids (GSLs) on the cell surface in the central nervous system (CNS). Its expression level, distribution pattern, and lipid composition are dependent upon cell and tissue type, developmental stage, and disease state, which suggests a potentially broad spectrum of functions of GM1 in various neurological and ...
Zhongwu Guo
openalex +3 more sources
Galactosidase β1 (GLB1); ganglioside GM1 (GM1) [PDF]
Science-Business eXchange, 2014 openalex +2 more sources
Trial of ganglioside GM1 in acute stroke. [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 1989 On the whole, these data indicate a possible effectiveness ofGMI in the treatment of stroke. We think that the real efficacy of the drug will be demonstrated not only by a larger study, but also through more selective criteria regarding the stroke (ischaemic or haemorrhagic) and the time of therapy (beginning and duration).
Ildebrando Appollonio +2 more
openalex +3 more sources
GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson's Disease. [PDF]
Sci Rep, 2019 Schneider JS +5 more
europepmc +3 more sources
ABSTRACT NUMBER: ESOC2026A2041 GM1 GANGLIOSIDE IN ACUTE ISCHEMIC STROKE: A RANDOMIZED, PLACEBO-CONTROLLED, MULTICENTER TRIAL [PDF]
Eur Stroke JZefeng Tan, Anding Xu
europepmc +3 more sources
GM1 ganglioside prevents axonal regeneration inhibition and cognitive deficits in a mouse model of traumatic brain injury. [PDF]
Sci Rep, 2018 Benady A +3 more
europepmc +3 more sources